Apigenin for Hair Loss: Reduce Scalp TGFbeta1 - nicehair.org

Apigenin for Hair Loss: Reduce Scalp TGFbeta1

Apigenin increases hair growth by reducing transforming growth factor beta 1 (TGFbeta1). TGFbeta1 causes hair to stop growing, so by reducing its effect in the scalp we can increase hair growth.

At least one study has shown that apigenin stimulates hair growth through down-regulation of a growth factor (TGF-ß1) while increasing the proliferation of human dermal papilla cells and human epidermal keratinocytes cells.

TGFbeta1 gives a signal to the hair in the scalp to stop it growing. By reducing or inhibiting TGFbeta1 we can prolong the growth of each hair, reducing hair loss.

How it works

Phases of hair growth:

There are three phases of hair growth.

  1. Anagen phase (growing phase)
  2. Catagen phase (transition phase)
  3. Telogen phase (resting phase)

The transforming growth factor, causes the hair follicle to transition from the anagen to the catagen phase.

Apigenin acts on the TGF-β1 to decrease its expression and continue the anagen phase.

More to follow.