Baicalin for Hair Loss: increases canonical Wnt/β-catenin signaling -

Baicalin for Hair Loss: increases canonical Wnt/β-catenin signaling

Baicalin plant extrat has been shown to increase hair growth by activating Wnt signaling pathways, leading to increased production of hair follicle cells in the dermal papilla.

Baicalin is a chemical extracted from the Radix plant. Interestingly, some research (cited below), hs shown that the chemical upregulates the Wnt signaling pathways Wnt3a, Wnt5a as well as frizzled 6 and disheveled 2. Quite a bit of previous research on the upregulation of the Wnt pathways has shown it causes the proliferation of dermal papilla cells. This could be understood in lay terms as follows:

When Baiclin is applied to the hair follicle, it seems to stimulate chemical messenger pathways, causing increased hair growth. Here’s an extract from the study:

The results indicate that baicalin stimulates the expression of Wnt3a, Wnt5a, frizzled 7 and disheveled 2 whilst inhibiting the Axin/casein kinase 1α/adenomatous polyposis coli/glycogen synthase kinase 3β degradation complex, leading to accumulation of β-catenin and activation of Wnt/β-catenin signaling. In addition, baicalin was observed to increase the alkaline phosphatase levels in dermal papillar cells, a process which was dependent on Wnt pathway activation.


Chemicals that can stimulate the Wnt signalling pathways are very exciting in hair loss research because they seem to be a safe and effective way to ‘switch on’ hair growth, without interfering with hormones, which may have adverse side effects.

More to follow.