How Senolytics Help Reduce Hair Loss
- Targeting Senescent Cells in Hair Follicles: Hair follicles can accumulate senescent cells with age, leading to inflammation and reduced growth. Senolytics clear these cells, reducing damage to surrounding tissues.
- Improving Follicle Regeneration: Removing senescent cells enhances the activity of hair follicle stem cells, which are crucial for initiating new hair growth cycles.
- Reducing Scalp Inflammation: Senescent cells release inflammatory molecules. Senolytics minimize this inflammation, promoting a healthier scalp environment conducive to hair growth.
Evidence Supporting Senolytic Topicals for Hair Loss
1. Quercetin and Fisetin as Senolytics
Research: These natural flavonoids selectively target and remove senescent cells in multiple tissues, including the skin.
“Fisetin and quercetin reduced senescent cell markers in aging skin, improving tissue health and reducing inflammation.”
EBioMedicine, 2018
2. Dasatinib and Quercetin Combination
Research: This combination has shown senolytic effects in animal models and human cell cultures, clearing senescent cells and improving tissue function.
“Dasatinib and quercetin reduced senescent cell burden and improved tissue health in aging models.”
Nature Medicine, 2018
3. Rapamycin as a Topical Senolytic
Research: A 2021 study showed that topical rapamycin reduced markers of skin aging and improved tissue elasticity.
“Topical rapamycin significantly reduced senescence markers, improving skin elasticity and appearance.”
Gerontology, 2021
What’s the Most Powerful and Effective Natural Senolytic Ingredient?
Natural senolytic ingredients are compounds derived from plants that target and eliminate senescent cells. Among these, fisetin and quercetin stand out as the most powerful based on current research. Here’s a closer look:
1. Fisetin
What It Is: Fisetin is a flavonoid found in strawberries, apples, cucumbers, and onions.
How It Works:
- Induces apoptosis (programmed cell death) in senescent cells while sparing healthy cells.
- Reduces inflammation by suppressing the secretion of pro-inflammatory molecules from senescent cells.
- Provides antioxidant effects, neutralizing free radicals that cause cellular damage.
Supporting Research:
“Fisetin was effective in reducing senescent cell markers in multiple tissues, extending median and maximum lifespan in aged mice.”
EBioMedicine, 2018
Sources: Strawberries (highest levels), supplementation (100–500 mg/day recommended in studies).
2. Quercetin
What It Is: Quercetin is a flavonoid present in onions, apples, berries, and green tea.
How It Works:
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Whats the best shampoo for hair loss? - Targets senescent cells selectively, especially when combined with other senolytics like dasatinib.
- Reduces inflammation by decreasing SASP factors like interleukins and TNF-α.
- Supports mitochondrial function and protects against oxidative stress.
Supporting Research:
“Quercetin and dasatinib reduced senescent cell burden and improved frailty-related symptoms in aged mice.”
Nature Medicine, 2018
Sources: Red onions (highest levels), apples, berries, supplementation (500–1000 mg/day).
Other Notable Natural Senolytics
- Piperlongumine: Found in the long pepper plant; preclinical studies suggest senolytic properties.
- Curcumin: Found in turmeric; offers anti-inflammatory benefits and may indirectly reduce senescence.
- EGCG: A compound in green tea with anti-inflammatory and mild senolytic effects.
How can you use senolytics to increase hair growth?
Many years back the very first version of the Growth Factors serum contained quercetin because it’s a powerful antioxidant, known for it’s positive effect on hair growth. The problem was it’s bright yellow and it would stain the users scalp and anything that touches it.
However, I’ve continued to research this topic and I will be considering adding fisetin to the topical, so if you want to add this to your regime, just order the Growth Factors serum.
