Diclofenac Gel for Hair Loss: How it Works – nicehair.org

Diclofenac Gel for Hair Loss: How it Works

Diclofenac is the active ingredient in Voltarol anti-inflammatory gel, so it’s not surprising to me that when applied to the scalp of balding men, it triggers new hair growth by reducing inflammation (a key cause of male pattern baldness).

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Last updated: Jan 30, 2020

Three male patients were visited in the Dermatology department and received treatment with topical 3% di-clofenac gel because of scalp AK. All patients also had concomitant androgenetic alopecia (AGA). During the follow-up visits, patients presented terminal hair growth on non-prior haired areas of the scalp. To the authors’ best knowledge, these are the first reported cases of hair growth due to topical diclofenac treatment. Conclusions: AGA is a heritable, androgen-dependent process. Various hypotheses proposed to explain its causes. Authors hypothesized that the inhibition of the COX-2 shown by diclofenac might act over the perifollicular micro-inflammation and the prostaglandins misbalance observed in the AGA, leading to hair growth. This finding may open further research lines to develop new treatments for AGA.
Research Gate


A doctor was treating patients who had dry scaly skin on their scalps. They were all bald men. He prescribed them Di-clofenac Gel for the dry skin. Diclofenac Gel is an anti-inflammatory. Several months later the patients came back and the doctor noticed new hair growth on their scalps.