EGCG for Hair Loss: Supress Androgen Receptors in the Scalp -

EGCG for Hair Loss: Supress Androgen Receptors in the Scalp

The androgen hormone DHT causes male pattern baldness (MPB) when it binds to androgen receptors in the scalp. Most MPB treatments involve reducing DHT, but this has major side effects, including loss of drive, inability to gain muscle, loss of sex drive and impotence. So a far better solution might be to reduce or suppress the androgen receptors in the scalp, so DHT cannot damage the hair follicles. That is precisely what EGCG does…

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Last updated: Jan 9, 2020

EGCG is a polyphenol found in green tea. A study by the Department of Dermatology at the University of Wisconsin discovered that ECGC binds with androgen receptors in the scalp, thus preventing DHT from binding with them.

Since DHT binding with receptors in the scalp hair follicles seems to be a key cause of male pattern baldness, topical application of EGCG seems to be a safe and effective way to reduce the effects of DHT on the hair follicles, therefore reducing male pattern baldness.

More to follow.

Here, we provide evidence that epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, is a direct antagonist of androgen action. In silico modeling and FRET-based competition assay showed that EGCG physically interacts with the ligand-binding domain of AR by replacing a high-affinity labeled ligand (IC50 0.4 μM). The functional consequence of this interaction was a decrease in AR-mediated transcriptional activation, which was due to EGCG mediated inhibition of interdomain N-C termini interaction of AR. Treatment with EGCG also repressed the transcriptional activation by a hotspot mutant AR (T877A) expressed ectopically as well as the endogenous AR mutant. As the physiological consequence of AR antagonism, EGCG repressed R1881-induced PCa cell growth. In a xenograft model, EGCG was found to inhibit AR nuclear translocation and protein expression. We also observed a significant down-regulation of androgen-regulated miRNA-21 and up-regulation of a tumor suppressor, miRNA-330, in tumors of mice treated with EGCG. Taken together, we provide evidence that EGCG functionally antagonizes androgen action at multiple levels, resulting in inhibition of PCa growth.—Siddiqui, I. A., Asim, M., Hafeez, B. B., Adhami, V. M., Tarapore, R. S., Mukhtar, H. Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer.
Extract from FASEB Journal