Dihydrotestosterone (DHT), which is a more potent form of testosterone has been shown to be closely linked with male pattern baldness. Many attempts have been taken to keep this hormone in check and control the resulting hair loss, but the approved medication, Propecia, has considerable side effects.
What is equol?
The clinical effectiveness of soy isoflavones may be a function of the ability to bio transform soy isoflavones to the more potent estrogenic metabolite, equol
Equol is identified as a metabolite of soy isoflavones, daidzin and daidzein in the human urine and is produced by the intestinal bacteria in some individuals. The clinical effectiveness of soy isoflavones may be a function of the ability to bio transform soy isoflavones to the more potent estrogenic metabolite, equol, which may enhance the actions of soy isoflavones, owing to its greater affinity for estrogen receptors, unique antiandrogenic properties, and superior antioxidant activity.
Anti androgen properties
it is evident that equol not only fights against hair loss but also promote hair growth
The antiandrogenic properties of equol makes it an effective chemical to stop hair loss because it blocks Dihydrotestosterone. What make this substance more beneficial than other antiandrogens is the fact that it binds directly to DHT and inactivates it without influencing testosterone. Soybean extracts have been found to affect not only hair pigmentation, but also the rate of hair growth, the dimensions of the hair follicle and hair shaft, and the appearance of the hair. So it is evident that equol not only fights against hair loss but also promote hair growth.
However not all individuals can produce equol. Only approximately one-third to one-half of the population is able to metabolize daidzein to equol. This is due to the differences in the microflora of different individuals. However research has indicated that short-term administration of soy isoflavones stimulated the production of serum equol and decreased the serum DHT level in healthy Japanese volunteers. These results suggest the possibility of converting equol non-producers to producers by prolonged and consistent soy isoflavones consumption. The time is not far when everybody can benefit from this amazing chemical agent.
- Seiberg, M., Liu, J. C., Babiarz, L., Sharlow, E., & Shapiro, S. (2001). Soymilk reduces hair growth and hair follicle dimensions. Experimental dermatology, 10(6), 405-413.
- Tanaka, M., Fujimoto, K., Chihara, Y., Torimoto, K., Yoneda, T., Tanaka, N., Hirayama, A., ….Hirao, Y. (2009). Isoflavone supplements stimulated the production of serum equol and decreased the serum dihydrotestosterone levels in healthy male volunteers. Prostate cancer and prostatic diseases, 12(3), 247-252.
- Yuan, J.P., Wang, J.H., & Liu X. (2007). Metabolism of dietary soy isoflavones to equol by human intestinal microflora -implications for health. Molecular nutrition & food research, 51(7), 765-781.