Microinflammation in the vicinity of the dermal papilla appears to precipitate or at least contribute to male pattern alopecia. To mimic inflammatory events that may prevail in this context, NHDFs were stimulated with IL-1α in the presence or absence of red clover extract alone, or a mixture of red clover extract and acetyl tetrapeptide-3, at two different concentrations (0.5% and 1%). DMS, a glucocorticoid with anti-inflammatory properties, served as positive control for inhibition of IL-8 secretion.
From ResearchGate
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