Hair follicle stem cells are among the most potent forms of stem cells in the human body There are two types of stem cells: embryonic stem cells and adult stem cells. While embryonic stem cells can differentiate into any type of cells, the adult stem cells have some limitations. The regeneration period of stem cells also depends on the type of organ stem cell. For example, in hair follicles and bone marrow, the stem cells divide frequently to replenish the damaged cells continuously throughout life. (Chen and Chong, 2012)
Hair Stem Cells
stem cells are activated by molecules released from intra-dermal fat tissue, hormones, neural activity, immune function and even the aging processThe hair follicle is a mini organ that supports various biological functions of the human body such as protecting from the cold and from injury as well as immunologic and sensory functions. Hair follicle stem cells are among the most potent forms of stem cells in the human body. Their diverse set of functions and ease of reproduction have made them one of the most popular choices when it comes to stem cell interventions such as the engineering of tissue for organ replacement or regenerative medicine. Their vast qualities and flexibility also explains why so much research and scientific literature has been devoted to studying their full potential. Hair follicle stem cells are kicked into action by a number of signals that come from their micro-environment but also from far larger bodily functions. Stem cells that are located in hair follicles interact with signals from the dermal papilla. While outside the follicle, stem cells are activated by molecules released from intra-dermal fat tissue, hormones, neural activity, immune function and even the aging process. Even external factors like the changing of seasons can interact with the activity of hair follicle stem cells. Due to their regrnerative properties and adaptiveness to various environments hair cells were chosen to become the model for stem cell biology (Chen and Chong, 2012).
Shiseido and Replicel have combined forces in order to develop one of the most advanced treatments for hair lossThe history of stem cell therapy for hair growth started with a company called Intercytex. Researchers tried to clone new hair follicles that were grown from the stem cells harvested from the back of the head. Their Phase 2 trials showed promising results in two thirds of their patients as they grew new hair after the stem cell treatment. Unfortunately, the company went out of business after the Phase 3 trials didn’t go as expected. In the last 3 years, more and more companies have announced their clinical trials for stem cell hair loss treatments. The major research teams developing treatments using stem cells are Replicel-Shiseido and Riken. The other new stem cell treatment that is already available is the HASCI method developed by Dr. Gho.