The 13 Best Topical Hair Loss Treatments in the World -

The 13 Best Topical Hair Loss Treatments in the World

There are hundreds of topical hair loss products on the market. But of all those hundreds that I’ve reviewed these are the only ones I would recommend.

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Last updated: Feb 8, 2020

I’ve researched the ingredients of nearly 100 topical hair loss treatments. You can see my write-ups here. The products listed on this page are the best in the world in my opinion. Read to the bottom for my explanation.

  • DS Labs Spectral DNC N

    DS Labs Spectral DNC N

    Around $35 for 2oz

    • Gingseng extract may promote blood circulation in the scalp
    • “Nanoxidil” (a new form of Minoxidil, developed by DS Labs) increases blood circulation in the scalp and is thought to penetrate the scalp skin better than normal Minoxidil
    • Aminexil is thought to improve blood circulation in the scalp and may help reduce perifollicular fibrosis
    • Arginine may help improve blood circulation in the scalp
    • Uses nanosomes to improve delivery of ingredients
    • Contains copper peptides, which may help reduce inflammation
    • Contains Adenosine, which has been shown to be effective in reducing hair loss in several major hair loss studies
    • Contains polyphenols, which are thought to help improve blood circulation in the scalp and according to DS Labs help regrowth along the hair line
    • Citrulline is a precursor to arginine, which helps improve blood circulation
    • Contains natural plant stem cells, which may help increase cell growth in the scalp
    • Contains Biotin, which supports healthy hair
    • Contains oleanolic acid, which may increase growth factors in the scalp, increasing hair growth
    • Retinol is an antioxidant, which is thought by some to reduce hair loss

    Buy online (USA)

    Buy online (UK)

  • Wick and Strom Apex Crown Topical hair loss solution

    Wick & Strom Apex Crown

    Around $20 for 4oz

    This is the only topical I’ve seen that contains ketoconazole, which makes it stand out. It contains a huge array of proven effective ingredients. And it’s super cheap! Amazon are also selling it at 15% off when you buy three bottles. This is a world class topical.


    Buy online (USA)

  • Pura D Or Scalp Serum

    Pura D’Or Scalp Serum

    Around $20 for 4oz

    • Contains Redensyl: a mixture shown to reduce inflammation, improve scalp blood circulation. Redensyl has received a lot of press attention because one study found that it’s more effective than minoxidil.
    • Arginine may help increase nitric oxide, which may dilate blood vessels, further improving blood circulation
    • Green tea contains EGCG, which binds with scalp androgen receptors, helping to reduce the amount of DHT that binds to receptors — reducing male pattern baldness
    • Pygeum, saw palmetto, beta sitosterol, pumpkin seed oil and nettle are all though to prevent the production of DHT by inhibitting 5 alpha reductase
    • Rosemary has been shown in studies to promote hair growth in some cases
    • Niacin and cayenne may help improve blood circulation in the scalp

    Buy online (USA)

    Buy online (UK)

  • Follinox 5

    Follinox 5

    Around $100 for 1oz

    • Emu oil is a good natural carrier oil with anti DHT, anti inflammatory and bactosteriatic properties
    • Contains 2% Minoxidil, which increases blood circulation in the scalp
    • Contains a vitamin complex, which may be high in antioxidants (which scavenge free-radicals) and may also help improve absorption of other ingredients
    • Retinol is an antioxidant, which is thought by some to reduce hair loss
    • Capsicum extract may help increase blood circulation in the scalp
    • Linoleic/alpha linonianic acid
    • Nettle and pygeum are natural DHT blockers
    • He shu wu is known in China for its hair growth promoting properties
    • Biotin is thought to help with hair health but it is not known if this works when applied topically
    • Zinc is known to help kill the common scalp fungi that causes dandruff and may also reduce hair loss
    • Kelp contains iodine, which is helpful in regulating healthy thyroid function (over active thyroid is a cause of hair loss) — however it is unlikely that this will have any benefit when used topically
    • Folic acid helps the body produce keratin
    • Arginine may help increase blood circulation in the scalp
    • Borage oil is rich in GLA, which may inhibit DHT


    Buy online (USA)

  • Revivigon topical hair loss spray

    Read next

    Best hair loss shampoos Whats the best shampoo for hair loss?


    Around $100 for 1oz

    • Contains linoleic and oleic acid, which prevent the conversion of testosterone into DHT
    • Contains saw palmetto, which may also prevent DHT production in the scalp
    • Studies suggest Beta Sitosterol also prevents conversion of testosterone to DHT by inhibiting the enzyme 5-alpha reductase
    • Caffeine may stimulate hair growth, though this is not proven
    • Procyanidin B2 (from apple polyphenols) is believed to stimulate blood circulation in the scalp
    • Zinc fights against common scalp fungi, helping to promote a healthy scalp environment


    Buy online (USA)

    Buy online (UK)

  • Lipogaine topical hair loss treatment


    Around $25 for 2oz

    • Contains 5% Minoxidil, which is clinically proven to increase blood circulation in the scalp and reduce hair loss in some individuals
    • Contains azelaic acid, which is also thought to promote blood circulation in the scalp
    • Contains retinol (vitamin A), an antioxidant which is thought to help reduce hair loss
    • Contains saw palmetto, which reduces the production of DHT (the most significant cause of hair loss in men)

    Buy online (USA)

    Buy online (UK)

  • DS Labs Spectral RS

    DS Labs Spectral RS

    Around $30 for 2oz

    • Contains nanosomes, which improve the absorption of the ingredients
    • Capsicum may help improve blood circulation in the scalp
    • Procyanidins may help improve blood circulation in the scalp
    • Adenosine may increase the hair’s growth phase, thus reducing hair loss
    • Aminexil may help improve blood circulation in the scalp
    • Retinol is an antioxidant and is thought to promote hair growth in some cases
    • Copper peptides benefit hair growth by reducing inflammation and possibly increasing blood circulation.


    Buy online (USA)

    Buy online (UK)

  • Crinagen Scalp Therapy Hair Loss Topical


    Around $25 for 2oz

    • Azelaic acid is thought to increase blood circulation in the scalp
    • Zinc is known to reduce dandruff and in some case has been shown to reduce hair loss
    • Niacin may increase blood circulation in the scalp


    Buy online (USA)

    Buy online (UK)

  • GowEasy Minoxidil and DHT Inhibitor

    GowEasy Minoxidil and DHT Inhibitor

    Around $27 for 2oz

    • Contains linoleic and oleic acid, which prevent the conversion of testosterone into DHT
    • Contains 5% minoxidil (highest commercially available strength) to increase blood flow to the hair
    • Contains 15% azelaic acid, which may reduce DHT in the scalp
    • Caffeine may stimulate hair growth, though this is not proven


    Buy online (USA)

  • JustNatural Grow New Hair Topical Hair Growth Treatment

    Just Natural Organic Hair Growth Spray

    Around $45 for 4oz

    • Pumpkin seed and flaxseed contain GLAs that prevent production of DHT
    • Saw palmetto, nettle and pygeum are three of the most well known natural DHT blockers
    • Green tea is a source of antioxidants and may help reduce DHT production
    • Grapeseed and ginkgo biloba may help improve blood circulation
    • High in nutritious organic ingredients and no “artificial” chemicals


    Buy online (USA)

  • Murad Hair Loss Serum

    Murad Hair Growth and Scalp Serum

    Around $27 for 1.7oz


    Buy online (USA)

  • Revellus human stem cell hair growth serum

    Revellus Human Stem Cell Hair Growth Serum

    Around $99 for 1.6oz

    This is an interesting product. It contains proteins derived from human stem cells! I posted an article on stem cells for hair growth a while back and it looks as though there’s a lot of potential. However, we don’t know for sure how the company has extracted the proteins and what exactly they are. Update coming soon!

    • Uses stem cells to promote hair growth. Could be beneficial but there is very little evidence to confirm the stem cell extracts in this product will increase hair growth.
    • Aloe vera is a natural plant extract, which has shown a lot of promise in improving skin health and some research suggests it may benefit hair health
    • Bamboo is a source of silica, which is why you often see it in hair products. Silica helps repair connective tissue, which is key for hair growth and skin health
    • Contains grapefruit — a source of citrulline (a precursor to arginine), which may help improve blood circulation by increasing NO2
    • Contains saw palmetto, which studies show helps reduce DHT, the primary cause of adrogenic alopecia
    • Contains “hydrolized keratin”. This is interesting but also lacks evidence to suggest it may benefit hair growth. Hair is made of keratin but we have no evidence to suggest that applying keratin to the scalp will increase hair growth, since keratin is made in the follicle base via a process of keratinization, where amino acids are turned into keratin. Whether adding keratin to the scalp would increase hair growth is debatable — I would say it’s unlikely but interesting nonetheless.


    Buy online (USA)

What to look for in a topical hair loss treatment

The key ingredients for maximizing hair growth are as follows:


Minoxidil increases blood circulation in the scalp by increasing the growth factor VEGF. VEGF is required for the formation of new blood vessels. When a hair is connected to a blood vessel it grows. When it dosconnects from the blood vessel it stops growing. By increasing VEGF we can prolong the length of time a hair remains connected to the blood vessel and therefore keep the hair in the ‘growth stage’ for longer.

For more information I recommend reading How to Increase Scalp VEGF.


Ketoconazole is believed to reduce scalp DHT. Men lose their hair more than women because men have more testosterone (an androgen hormone). Testosterone is converted into DHT in various parts of the body, including the scalp. DHT is what causes most hair loss. Ketoconazole supposedly prevents testosterone from being converted into DHT — and studies seem to support this assertion.


Aminexil reduces fibrosis in the scalp. It’s believed by many hair loss researchers that fibrosis is ultimately what causes at least some male pattern hair loss. It’s likely that DHT or perhaps stress hormones, such as cortisol (or perhaps a combination of the both) lead to increased scalp inflammation, which causes fibrosis in the hair follicles. Fibrosis seems to irreversably destroy the hair follicles. Reducing scalp fibrosis seems to be a sensible step to reducing hair loss. However, if you want to reverse damage caused by fibrosis you will need to use a method of wound-induced hair follicle neogenesis, in order to generate completewly new hair follicles.

Anti-inflammatory ingredients

As I just mentioned, inflammation seems to play a key role in hair loss. I’ve seen amazing hair regrowth results achieved with topical application of anti-inflammatories. Take a look at the results of one patient who used the anti-inflammatory cream Voltarol for an example.

I’ve also seen great results from peppermint oil (another anti-inflammatory).

Ingredients that increase growth factors VEGF, FGF7, EGF and IGF-1

Several growth factors have been shown to increase hair growth in the scalp. Certain chemicals are known to increase those growth factors in the scalp. For example, Minoxidil increases VEGF. We can increase IGF-1 by applying the growth factor directly to the scalp. Oleanolic acid has been shown to increase VEGF and IGF-1. To learn more about growth factors, read the below articles:

Hair Follicle Neogenesis Growth Factors Treatment

I recommend also reading: How to Increase Hair Density Using ‘Growth Factors’.

The only product I know that contains ingredients that significantly increase scalp growth factors is the Hair Follicle Neogenesis Growth Factor Treatment.

Ingredients that increase PGE2

PGE2 seems to play an important role in hair growth. I published an article demonstrating results of increasing PGE2 on hair growth.

It’s very rare to find a hair loss treatment that increases PGE2. One ingredient that does (and it also decreases inflammation) is Sulfasalazine. You could also try using Bimatoprost, which has shown amazing results. However it will cost you about $2000 for a gram!

What’s the best topical for women

For women, inflammation is perhaps the most important thing to combat. That and increasing growth factors. Minoxidil will also help because it will increase blood circulation and prolong the growth phase of the hair follicles. In many cases the same products that work for men will also be beneficial for women. Women don’t tend to need DHT blocking ingredients, since women usually have far less testosterone than men. However, there are of course exceptions to that rule and it might be elevated DHT (often associated with PCOS) that’s the cause of the hair loss.

For women I’d recommend starting out with a treatment that increase growth factors, increases blood circulation and reduces inflammation. A product like the Hair Follicle Neogenesis Growth Factors Treatment for Women is probably the best.

If you’re a woman and you have PCOS, use a treatment that also reduces androgen receptor availability and blocks DHT. That would include products that contain ketoconazole, minoxidil, EGCG and RU58841.

Join the Conversation


  1. Hi Chris,
    Is Minxodil safe to use , because some people says that it had real side-effects on long-term , and they also says that if a person use it once he need to continue with it for a lifetime cause once he stopped using it for a while the hair will return as it was !!?
    Is that true?
    All the best;)

    1. Hi Abdulla,
      Minoxidil is one of the safer hair loss treatments in my view. Side effects are rare (you can see a full list of Minoxidil side effects here). On it’s own I don’t think it is very effective, but in products like the ones listed above (particularly Spectral DNC-N with it’s Nanoxidil), it should have some noticeable benefit to hair growth.
      Unfortunately, as with all hair loss treatments, if you stop using them, your hair will continue to fall out as before. The only way to truly solve that problem is to eliminate the underlying causes of the hair loss — and this is covered in detail in my eBook.
      All the best,

  2. Hi Chris,
    I’m thinking of buying you ebook, but before I do, I’d just like to make sure that you don’t depend on minoxidil in your tonic. I can’t use it because it gives me sides.

    1. Hi art,
      There’s no minoxidil in my custom hair growth tonic. It uses all natural ingredients to reduce inflammation, increase blood circulation, decrease DHT and act as an anti bacterial amongst other things.
      All the best,

  3. Hi Chris,
    I am suffering from TE and was told to use monoxidil, which I have been doing for three weeks now. However, after significant research including your site (which is a goldmine) I have decided also to try bhringaraja oil (just purchased a product that also includes neem and rosemary too).
    How would you propose using both monoxidil and bhringaraja? One in the morning one at night? Monoxidil daily, the oil less often? Do you have any concerns about using both?
    Looking forward to your suggestions
    Many thanks

    1. Hi Pushpa,
      Yes these treatments are for both men and women. They mainly work by increasing blood circulation in the scalp (thus increasing supp[ly of nutrients to the hair via the blood stream) and by enhancing hair and scalp health.

  4. Liposome is good but hair needs nutrition . Basically like a plant . Needs water so the scalp needs moisturiser.
    But hair needs food like animo acids but you have to send them to the scalp otherwise they will go elsewhere no matter how much you use .
    Apple cider vinegar and Capiscan work better than minoxidil . Like the soil is to a plant the scalp is to hair so you must fertilise the scalp .
    Taking finasteride and putting minoxidil is not going to solve the problem .
    Finasteride has nasty side effects . You can get rid of Dht with a change of lifestyle . Eating foods that block DHT and eating those which cause it .
    A good chemical free shampoo and brushing with a good brush will help too

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