Topical Difenciprone (diphenylcyclopropenone) for Hair Loss: should you try it? – nicehair.org

Topical Difenciprone (diphenylcyclopropenone) for Hair Loss: should you try it?

Difenciprone, or diphenylcyclopropenone has been used topically to stimulate hair growth in patients with Alopecia Areata with some success. So, is it worth trying for people with other types of hair loss, such as male pattern baldness?

Topical diphenylcyclopropenone (DPCP) is a chemical compound used in dermatology to treat certain skin conditions, particularly alopecia areata, a type of autoimmune hair loss. The exact mechanism of how DPCP works is not fully understood, but it is believed to involve the modulation of the immune system.

DPCP is a strong allergen, and when it is applied to the skin, it causes an allergic reaction. The body’s immune response to this allergic reaction may somehow interfere with the autoimmune response against the hair follicles. It is believed that this allergic response might “redirect” the immune system away from attacking hair follicles, thus allowing hair regrowth.

From the study

After 6 months’ therapy, hair regrowth greater than 50% was observed in 21 patients, while worsening, no regrowth, or regrowth of less than 50% was seen in 18 patients. Regrowth exceeding 50% of initial loss was observed in 12 of 17 patients with baseline hair loss < 50%, in 9 of 22 patients with severe alopecia, and in 4 of 9 patients with alopecia totalis. Both groups showed significant improvement with higher efficacy in group B (54%) than group A (46%). National Library of Medicine

Will I be trying it?

This is not a treatment I am currently conisdering trying. Although it is intriging, the results are not anything spectacular and the fact that it causes an alergic reaction is slightly worrying. So for now, I will be parking this treatment unless further news arrises.