Topical Luteolin for Hair Loss: A Potent PGD2 Inhibitor - nicehair.org

Topical Luteolin for Hair Loss: A Potent PGD2 Inhibitor

Luteolin is a flavonoid found in many plants, which can reduce hair loss by reducing scalp PGD2. It’s another interesting example of an anti-allergy treatment, which translates well as a hair loss treatment.

Luteolin is a natural plant extract and another example I’ve noticed of anti-histamines that reduce hair loss. This is due to their effect of reducing scalp PGD2. Previous studies have noted that balding scalps have significantly higher levels of the protein prostaglandin D2 (PGD2). By reducing this protein or suppressing the receptor GPR33, which PGD2 binds to, we can reduce hair loss associated with this action.

Since Luteolin, like other anti-allergy treatments, is very cheap and low-risk; it seems to be a good prospective treatment for hair loss. Here’s an abstract from the study:

Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner.

Via PubMed