Topical Luteolin for Hair Loss: A Potent PGD2 Inhibitor

Luteolin is a natural plant extract and another example I’ve noticed of anti-histamines that reduce hair loss. This is due to their effect of reducing scalp PGD2. Previous studies have noted that balding scalps have significantly higher levels of the protein prostaglandin D2 (PGD2). By reducing this protein or suppressing the receptor GPR33, which PGD2 binds to, we can reduce hair loss associated with this action.

Since Luteolin, like other anti-allergy treatments, is very cheap and low-risk; it seems to be a good prospective treatment for hair loss. Here’s an abstract from the study:

Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner.

Via PubMed

What is Luteolin?

Luteolin is a natural flavonoid compound belonging to a class of plant pigments known as flavones. Flavonoids are frequently found in fruits, vegetables, and herbs and they are known for their potential health benefits due to their antioxidant and anti-inflammatory properties. Luteolin is commonly found in foods like celery, green peppers, parsley, thyme, and chamomile tea.

Research suggests that luteolin may have several potential health benefits, including:

Antioxidant Activity: Luteolin has been shown to possess antioxidant properties, meaning it can help neutralize harmful free radicals in the body. Free radicals are molecules that can cause oxidative stress and damage cells, potentially leading to various diseases and aging-related effects.

Anti-Inflammatory Effects: Luteolin has anti-inflammatory properties that may help reduce inflammation in the body. Chronic inflammation is associated with various health conditions, including heart disease, diabetes, and neurodegenerative disorders.

Neuroprotective Potential: Some studies have suggested that luteolin might have neuroprotective effects, meaning it could help protect nerve cells from damage and potentially have a role in conditions like Alzheimer’s disease and Parkinson’s disease.

Cancer Prevention: There is ongoing research into luteolin’s potential as a cancer-preventive compound. Some studies have indicated that luteolin might have anti-cancer properties by interfering with various cellular processes involved in cancer development.

Allergy Relief: Luteolin has been investigated for its potential to alleviate allergy symptoms. It might work by inhibiting the release of inflammatory molecules that contribute to allergic reactions.

Cardiovascular Health: Some research suggests that luteolin could have positive effects on cardiovascular health by influencing factors like blood pressure and cholesterol levels.

Will I be trying it?

I’ve just bulk purchased a large bag of pure, organic Luteloin powder. I’ll be using it in the Hair Follicle Neogenesis Growth Factors serum going forward. Since its safe, well tolerated, extremely beneficial (in terms of health) and possesses anti-inflammatory properties and antioxidant properties it’s a great addition to the topical. I’ve wanted to add more anti histamine and anti inflammatory ingredients for a while and this is a great choice.