Topical Prostaglandin Analogs for Hair Loss: Results and How to Use Them - nicehair.org

Topical Prostaglandin Analogs for Hair Loss: Results and How to Use Them

Prostaglandin analogs/analogues are a class of medications that mimic the effects of naturally occurring prostaglandins. Prostaglandins are hormone-like substances that play various roles in the body, including regulating inflammation, blood flow, and cell growth.

We know that increasing the naturally occuring prostaglandin PGE2 and decreasing PGD2 can increase hair growth, so is it possible to apply an analog to achieve similar or even greater effects?

By increasing and decreasing some prostaglandins it’s been shown in multiple studies that hair growth can be increased. This seems to happen by increasing the growth phase of the hair follicles, so they stay growing for longer and shed less.

From the study:

There were six randomized controlled trials included in this meta-analysis. All studies compared prostaglandin analogs with placebo, and one trial consisted of two sets of data. The results showed that prostaglandin analogs could significantly improve the hair length and density (p < 0.001). As far as adverse events are concerned, there was no significant difference between the experimental group and the control group. Frontiers
Bimatoprost, Latanoprost and Cetrizine can imprve this balance and increase hair growth.

The topical application of bimatoprost 0.03% lotion daily for 12 and 16 weeks has been found to significantly increase the diameter of vellus hair and the number of vellus hairs
Frontiers

So, which prostaglandin analog is best for increasing hair growth?

The meta study linked above analysed six studies involving over 600 people who used the above treatments. Unfortunately findings are inconclusive due to varying methods and volumes of the analogs used.

Conclusions: Should you try using prostaglandin analogs to increase your hair growth?

I’ve been tempted for some time to add Bimatoprost or Latanoprost to my hair growth serum called Growth Factors. However, due to unknown side-effects I have decided against it. However, I have included a very small amount of Cetrizine. For a long time I’ve noted a connection between inflammatory reponse, histamine and PGD2. By reducing these things it seems possible to stimulate har growth. Cetrizine is also a safe option available over the counter without prescription. For now I’ll stick with Cetrizine.