Chris Carter, Author at NiceHair.org

3 ways you can trigger new hair growth at home

In this article, we’re going to discuss proven ways, according to studies carried out that can be used to grow hair on a bald scalp. One thing that is obvious is that a bald scalp is not always bald, and at a point in time it has been occupied by hair shafts. Before going into details about these methods, it is important to have little education about the hair.

The hair is made up of two separate structures which are; the hair follicle and the hair shaft. The hair we see growing on our scalp is the hair shaft, while the second part that is hidden below the skin is the hair follicle, which is the living part of the hair. The cells that produce new hairs are located in the hair follicle. The follicle is made up of tiny blood vessels known as capillaries. The hair shaft is in the real sense dead cells that are disposable at any time, while the hair follicle remains the determinant factor to hair growth on the scalp. It can be said that the more nutrients getting to the follicle, the greater the hair produced on the scalp. Therefore, blood circulation is integral to hair production.

Scalp massages

Well, this might sound unbelievable and doubtful, however, studies have shown that stimulating certain part of the scalp helps to relax the muscles and increase blood flow (Choy, 2012). Researchers have shown that massaging the scalp for 20 minutes every day could stimulate new hair growth (Choy, 2012). Below is a table showing effect of scalp massages on hair loss before and after massage at the end of 300 days.

Scalp massaging for hair growth research results

The results showed that scalp massages are effective in reducing hair loss. However, mastering technique of scalp massaging is essential for effectiveness. It is advisable to rub the scalp in circular motion on the sides (above the ears), then at the front, then at the back for 20 minutes every day.

Mesotherapy

Mesotherapy hair growth results

This is another method that has been proven to be a useful way of growing hair on a bald patch. This method involves stimulating hair growth through mechanical stimulations by inflicting the scalp with minor wounds thereby causing more cells to be created. During the tissue repair and cellular reproductions that follow, collagen and elastin are produced which improve elasticity and lead to more growth of hairs. One possible instrument for use during mesotheraphy is the dermaroller, which has sharp pointed ends that can cause wounds on a bald scalp. Another study has shown that combining mixodil and dermaroller can cause hair growth. This picture below showed the effect of this treatment within 12 weeks.

Microneedling

This is another method of growing hair using mesotheraphy principle. However, in this case, a microneedle is used instead of dermaroller. The effect of this treatment can be seen in the picture below (Dhurat et al., 2013).

Microneedling hair growth results

Dermarollers and microneedle stamps can be purchased cheaply online.

Peppermint oil

A 2014 study conducted in South Korea showed that rubbing peppermint oil on the scalp could successfully trigger regrowth of hair (Oh & Kim, 2014). Using Peppermint in some tropical solution on daily basis could be an effective method to regrow hair. The effectiveness of this treatment on hair growth is shown in the figure below.

Peppermint oil hair regrowth results

Hair plucking

A study has shown there’s a possibility for growing new hairs by plucking in a particular pattern. The study revealed that when hairis plucked from mice, they grew more hair than before (Mann et al., 1993). This is yet to be practiced on humans, but since humans are genetically close to mice, trying this method could offer an inexpensive way of regrowing hair.

Conclusion

One central theme common to all the methods discussed in this article is to increase blood circulation in the scalp. Different methods exploit different means of ensuring the nutrients necessary for hair growth are made accessible to the hair follicle.

References and further reading

  1. Choy, H. (2012). Detumescence Therapy of Human Scalp for Natural Hair Regrowth. J Clin Exp Dermatol Res, 3(138), 2.
  2. Dhurat, R., Sukesh, M. S., Avhad, G., Dandale, A., Pal, A., & Pund, P. (2013). A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study. International journal of trichology, 5(1), 6.
  3. Koyama, T., Kobayashi, K., Hama, T., Murakami, K., & Ogawa, R. (2016). Standardized scalp massage results in increased hair thickness by inducing stretching forces to dermal papilla cells in the subcutaneous tissue. Eplasty, 16.
  4. Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L., & Dunn, A. R. (1993). Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell, 73(2), 249-261.
  5. Oh, J. Y., Park, M. A., & Kim, Y. C. (2014). Peppermint oil promotes hair growth without toxic signs. Toxicological research, 30(4), 297.

Can Estrogen Cause Hair Loss in Men?

Estrogen hair loss

For many years it was believed that high levels of testosterone alone caused male pattern baldness (MPB). Testosterone, the primary male sex hormone is converted to dihydrotestosterone (DHT) by the 5a-reductase enzyme. DHT is a super-testosterone and high levels of it increase the risk of developing male pattern baldness. The higher the levels of free testosterone that circulate in the body, the more DHT that is produced. The higher the body’s DHT levels – and here we’re talking about tissue DHT, as found in the scalp, rather than serum DHT – the greater the hair loss (at least that’s the theory). DHT has a far greater affinity for the androgen receptors responsible for MPB than ordinary testosterone. So as you might expect, higher levels of testosterone lead to greater hair loss.

The problem with this theory is that as men age they are statistically more likely to lose their hair. But paradoxically, testosterone levels tend to decrease with age. Further, testosterone levels are not much different between balding and non-balding men. Male pattern baldness has also been found in men with low testosterone levels.

Estrogen, Cortisol And Their Effect On Hormonal Balance

Current research suggests that it’s the female sex hormone, estrogen, which plays a key role in male pattern baldness. It’s not estrogen levels on their own that’s the problem. In fact, estrogen is good for hair growth. Rather it’s the ratio between testosterone and estrogen levels.

This hormonal imbalance can occur in both men and women at all ages, and there are many reasons why it occurs. As we’ve just noted, aging can reduce testosterone levels, which in turn affects the testosterone:estrogen ratio. The modern diet can also reduce testosterone levels. For women who have gone through the menopause, their estrogen levels are reduced by as much as 90%. An underperforming thyroid may also skew the testosterone:estrogen ratio.

Another example of a hormonal imbalance which can promote hair loss is caused by stress. In response to a crisis, the body’s adrenal glands produce cortisol, a hormone which triggers the flight-or-fight response. Unfortunately this extra cortisol is produced at the expense of hormones which sustain hair growth. This is why long-term stress and anxiety can lead to thinning hair.

Estrogen And Dietary Solutions to MPB

Estrogen is associated with healthy hair growth. Not only does it protect against hair loss by reducing DHT conversion, it stimulates new hair and slows the growing – or anagen – phase. Essentially, estrogen works its wonders by overriding the effects of testosterone.

Estrogen should not be directly administered to men with MPB because it shuts off testosterone. The amounts needed to have any perceptible effect on hair loss can cause symptoms such as breast growth and decreased sex drive.

A far better solution is to take a supplement, such as Finasteride, a key ingredient in the hair loss medication, Propecia. Finasteride is an estrogen booster, which reduces the conversion of free testosterone to DHT. Estrogen biosynthesis is also known as aromatase activity.

Switching to a diet rich in fruit and vegetables can also support healthy hair growth. Such a whole-food diet improves hormonal balance and provides essential nutrients. Reducing junk food, caffeine and alcohol prevents follicle inflammation, which inhibits hair growth.

References and further reading

  1. Dihydrotestosterone: 20 Ways to Increase DHT and 5-a Reductase Levels Naturally, by Ali Kuoppala
  2. How Does Finasteride Impact Testosterone and Estrogen Levels, Sept 4, 2015
  3. Estrogen – follacure.com
  4. How to Prevent and Reverse Baldness, Simply, Safely, and Naturally, by Dr Nick Delgado
  5. Men: Stop Thinking Your Hair Loss Is Due To High Testosterone, by Rob, April 21, 2014
  6. Hormones and Hair Loss – How Cortisol Affects Hair Growth, by Nutrafol Hair Expert, July 11, 2016

Should I take Propecia (Finasteride)?

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Should I take Propecia Finasteride

Propecia is probably the best at home treatment for hair loss in terms of effectiveness and ease of use. All you have to do is take a pill once a day.

People report complete cessation of hair loss but reports of hair regrowing just from taking Propecia are rare.

The longest clinical trial for a hair loss treatment was for the purposes of evaluating the efficacy of Finasteride. In the 1990s, 1,553 men suffering from androgenic alopecia were given one mg daily doses of Finasteride or a placebo over a 12 month period. Each was allowed to enroll in the following one-year trial extension, for up to five years. 1,215 men enrolled for the second trial extension, randomized to receive either finasteride or the placebo. Results showed significant hair regrowth for those in the blinded Finasteride group, as opposed to the placebo group. Baseline hair counts averaged 876 hairs in a 1” circle of scalp.

After the first year, finasteride patients averaged an extra 126 hairs in the same area over those taking the placebo. After five years this figure had increased to 277. Examiners recorded that 77% of those on finasteride showed increased hair regrowth after five years. This compared with only 15% in the placebo group.

Read more

Would I recommend it?

Personally I would never use Propecia because I believe it alters your personality. By altering your hormonal balance it essentially makes you ‘less of a man’. It can take away your sex drive, take away your drive to achieve goals; and even make you lose your interest in women. It can basically take away the things that make you a man. So if it’s a choice between being a man and losing my hair I’ll choose to lose my hair.

What’s the alternative?

Take a look at this. It’s a chart that shows cortisol hormone levels throughout the day. Cortisol is the main stress hormone — the hormone produced when you’re stressed.

Now take a look at this chart. It shows testosterone levels throughout the day. Testosterone is the hormone that is converted into DHT by the body.

Notice the charts are quite similar in shape?

Here’s a quote from Dr Seymour Weaver, a prominent hair loss researcher:

Cortisol is in essence, a stress hormone. … When we have high levels of cortisol coursing through the body this leads to an increase in adrenaline, testosterone and in particular, a hormone known as dihydrotestosterone or DHT

So cortisol leads to increased DHT. It also causes reduced testosterone:

Over the years, some studies have suggested that the stress hormone cortisol and the sex hormone testosterone work against each other. This has led to the theory that stress may cause infertility and loss of libido in men by inhibiting testosterone.

A study published in the journal Hormones and Behavior provides new evidence for what’s called the cortisol testosterone hormonal axis. Researchers measured hormone levels in 57 men who were pitted against each other in one-on-one competition. Their cortisol and testosterone levels were measured after competing. The men who lost were asked if they wanted to compete again. All the men who declined had high cortisol levels and had a significant drop in their testosterone. The researchers believe this is a hormonal response that prepares the body to respond to stress by escaping danger.
Everydayhealth.com

So what’s the absolute best thing you can do to safely and naturally reduce your DHT levels, while also improving your life in many other ways?

The answer is to reduce your cortisol levels.

This, I believe is one of the keys to stopping hair loss. In my opinion hair loss is not just caused by DHT; it’s caused by a combination of DHT and high stress levels. These are the two most important factors that initiate the direct causes of hair loss:

It’s likely that the factors above, which are directly linked to increased hair loss, are caused by elevated DHT. Since cortisol may lead to elevated DHT as well as causing other health problems, reducing your cortisol levels by reducing stress may be the key to stopping the root cause of hair loss.

To learn how to reduce your cortisol levels check out my comprehensive ultimate guide to reducing cortisol.

Can hair loss be a sign of cancer?

Summary:

  • Hair loss IS NOT a direct sign of cancer.
  • People associate cancer with hair loss because a common treatment for cancer — chemotherapy — often causes hair loss.
  • This means many people with cancer lose their hair after receiving chemotherapy.
  • As a result some people think hair loss is a sign you might have cancer. But it isn’t.
  • To be completely clear; if you’re losing your hair you shouldn’t be concerned that you have cancer.
  • Hair loss is very common and there are many possible causes.
  • The most common cause of hair loss is a hormone by-product of testosterone called DHT.
  • DHT is thought to be the most significant cause of hair loss, which is why men tend to lose their hair more often than women — because men tend to have much higher levels of DHT than women.
  • Prostate cancer feeds on testosterone.
  • One treatment for prostate cancer is a drug that reduces testosterone significantly.
  • If you’re male and you experience male pattern baldness at a young age you should get a prostate exam, especially if you have a family history of prostate cancer.

Cancer hair loss

Hair loss is not a sign of cancer. People associate hair loss with cancer because it’s one of the most well-known side effects of cancer treatment. Chemotherapy/radiotherapy is a type of cancer treatment that causes hair loss.

Chemotherapy can cause:

  • mild thinning of hair
  • partial hair loss, or loss of patches of hair
  • complete hair loss (alopecia)

What about rapid or sudden hair loss?

Even rapid or sudden hair loss is not a sign of cancer. A sudden increase in hair loss might be due to stress, which may accellerate hair loss by increasing cortisol hormone in the body. It’s also possible the hair loss is due to an auto immune disease or other undiagnosed underlying condition. If the hair loss is unexpected you should visit your doctor for a check-up.

Young male pattern baldness may be a sign that prostate cancer is likely later in life

In some cases early hair loss in men is associated with double the normal risk of developing prostate cancer as suggested in a study published in Annals of Oncology, 388 prostate cancer patients and 281 healthy men were questioned about their history of hair loss.

The researchers, led by Philippe Giraud of the Paris Descartes University, can’t say for sure why early-onset baldness and prostate cancer are linked, but they suspect male sex hormone testosterone may play a role in both conditions.

How Does Chemotherapy Causes Hair Loss?

While the main purpose of chemotherapy is to attack the malignant cancer cells in the body, it also adversely attacks all of the healthy and fast growing cells in the body, including hair follicles on the scalp and other parts of the body. This is why hair falls out during chemotherapy treatment. Killing the hair follicles not only causes hair to fall out much faster than usual for some, while for others, it falls out in large clumps.

The rate and intensity at which the hair follicles are attacked varies based upon the level of treatment and the dosage of the chemotherapy drug. Hair usually begins falling out two to four weeks after you start treatment.

scalp cooling was linked to the prevention of significant hair loss in about half the women using the devices

The good news is that hair loss due to cancer treatment is not permanent and, oftentimes, the hair grows back within three to six months after treatment ends; however, the texture, color, and thickness might be different at first. As the hair follicles slowly recover from the treatment and gain back their strength, the hair will eventually return to its former thickness.

Controlling hair loss during chemotherapy

Two studies by researchers from cancer centers across the US found that scalp cooling devices, ice packs or cooling caps can help reduce hair loss during chemotherapy. The studies looked at women undergoing chemotherapy for breast cancer. In both studies, scalp cooling was linked to the prevention of significant hair loss in about half the women using the devices. Both studies were published February 14 in the Journal of the American Medical Association.

The theory behind scalp hypothermia is that the cooling tightens up or constricts blood vessels in the scalp. This constriction is thought to reduce the amount of chemo that reaches the cells of the hair follicles. The cold also decreases the activity of the hair follicles and makes them less attractive to chemo, which targets rapidly dividing cells. This could reduce the effect of chemo on the follicle cells and, as a result, prevent or reduce hair loss from the scalp.

How to Reduce Cortisol Levels Naturally: A Complete Guide

How to reduce cortisol

Cortisol is a steroid hormone often referred to as the stress hormone. It is produced by the zona fasciculta in the adrenal gland and released in the body as a response to stress or low blood sugar. Its role is to increase blood sugar, to supress the immune system or to help in the metabolism of fat, proteins or carbohydrates. While it plays an essential part in the body’s well-being, high cortisol levels can also have serious health related side-effects.

What causes high cortisol levels?

While there are numerous causes for high cortisol levels in the body, one of the biggest causes is stress, particularly the constant stress that is often the result of a fast-paced, competitive work environment.

Other causes include liver or kidney disease, depression, obesity or hyperthyroidism. Infections, illness and certain injuries can also lead to increased cortisol levels.

How to reduce cortisol naturally

There are numerous ways to reduce cortisol to healthy levels; however, any cortisol related issues and potential solutions should be discussed with a licensed physician before being attempted.

Reduce sugar intake

What you eat has an influence on how your body behaves. When it comes to reducing cortisol, one of the easiest ways to do so is to look at your sugar intake.

Consistent high-sugar intake has been shown to keep cortisol levels elevated (Iranmanesh et al., 2011) A study by Gyllenhammer et al. (2013) also suggests that increased cortisol levels due to high sugar intake are particularly visible in overweight and obese individuals.

Paradoxically, in lower amounts without prolonged use, sugar has also been shown to have a reducing effect on stress induced cortisol according to a 2015 study. (Tryon MS et al., 2015)

Increase omega 3 fatty acids

Best organic EFA omega oils

There are, of course, numerous items that help reduce or regulate cortisol levels in the body. One of the most popular is omega 3 fatty acids. (Delarue J. et al., 2003). Fish oils are an excellent source of omega 3 acids that have been shown to reduce cortisol basal levels as well as perceived stress. (Barbadoro P et al., 2013)

Increase fruit consumption

Bananas

Fruits are also an important factor in reducing cortisol. Bananas and pears have been shown to reduce cortisol levels, particularly after strenuous exercise. (Nieman DC et al., 2015) Citrus and spinach have also been said to help reduce cortisol or negative effects associated with cortisol, however further research is needed to confirm the findings.

Drink more tea

Green tea reduces DHT

Black and green teas are affordable and easy ways to reduce and regulate cortisol levels. In a randomised double blind trial meant to show the effects of black tea consumption over a period of 6 weeks, results showed a reduction of cortisol levels as well as an increase in relaxation. (Steptoe A. et al., 2006). But hydration, regardless of the positive effects that black and green tea offers, is also essential in maintaining good cortisol levels. A study performed on athletes exercising at different intensity levels suggests that dehydration leads to increased cortisol levels. So in order to keep stress hormone imbalances at bay, proper hydration is a must. (Maresh CM. et al., 2006)

Eat dark chocolate

Dark chocolate is another key ingredient when it comes to healthy cortisol levels. Dark chocolate has been shown to reduce the urinary excretion of the stress hormone cortisol while also normalizing stress-related differences in energy metabolism. (Martin FP et al., 2009)

Take a pro-biotic supplement

Probiotics are another natural solution to cortisol issues. You can theoritically increase your guts good bacteria by eating yogurt, kim-chi, sourkraut, kefir and a host of other fermented foods. A study performed on 45 volunteers showed that a 3 week diet that included probiotics marked a significant decrease in cortisol levels as well as other benefits to gut bacteria and emotional bias. (Schmidt K et al., 2015).

However, it might be more effetcive to consume a pro-biotic supplement that can pass the bacteruia through your stomach without it being destroyed by your stomach acid. It’s also worth consuming foods that feed your gut’s bacteria, such as green baby salad leaves like rocket, spinach and kale.

Reduce foods that increase your cortisol levels

Excluding certain foods and drinks from your diet is as much a part of maintaining a healthy cortisol level as is eating the right stuff.

Eliminate caffeine

One of the most efficient ways of preventing cortisol spikes is to eliminate caffeine from your daily diet. Caffeine can increase cortisol levels as much as 44 per cent immediately after consumption. (Beaven et al., 2008). Switching to decaff can reduce how much your cortisol levels spike but cannot cut the effect entirely. (Lovallo et al., 2008)

Reduce alcohol consumption

Alcohol is another substance that should be avoided or used in moderation in order to keep cortisol down. A study performed on 2693 men and 977 women showed that prolonged alcohol consumption can lead to increased cortisol levels in both men and women. (Badrick et al., 2008)

Exercise

Running

Exercise has a contentious relationship with cortisol. On the one hand, it plays an essential role in naturally reducing cortisol while increasing testosterone, as well as numerous other benefits. On the other hand, it can greatly increase cortisol levels when done incorrectly.

Endurance training has been repeatedly shown to significantly increase cortisol levels, with growth being tied to the intensity of the effort according to a study performed on elite athletes and published in the Journal of Behavioural Medicine. (Perna et al., 1995).

Strength training is often seen as a good way of staying fit, healthy, reducing cortisol and increasing testosterone, however, this all applies when done in moderation. Overtraining can have disastrous effects on cortisol levels as confirmed by a 2002 study which looked at overtraining and the tools required to measure it. (Urhausen A et al., 2002) The study concluded that overtraining leads to distorted levels of testosterone and cortisol which can impair exercise performance in the long term.

Even moderate exercise can be counterproductive, as research shows that it can cause a significant rise in cortisol levels when done in a state of stress, increasing recovery time and opening a larger window for potential injuries (Perna et al., 1995).

Exercise, particularly strength training, can have a positive impact on cortisol and can lead to a healthy lifestyle when done in moderation and when pre-existing stress levels are taken into consideration.

Listen to Instrumental Music

Music is another science backed way to reduce cortisol levels. In a study performed in 2011, a team of researchers looked into the effects of listening to instrumental music during surgery. Among the numerous benefits this approach boasts, the team concluded that instrumental music has a calming effect that helps reduce cortisol levels in the body. (Stefan Koelsch et al., 2011)

Have Human Interaction: and in particular, laugh a lot

Humans are social animals; we evolved as groups and we certainly need human contact to lead healthy, meaningful fulfilling lives. This aspect is also relevant when it comes to reducing cortisol levels naturally.
Laughter for example is an easy way to reduce cortisol as a 1989 study performed on 10 subjects suggests. Laughing helps reduce stress while also significantly lowering cortisol levels. (Berk LS et al., 1989)

Get a massage

Human contact is also important. Massage therapy for example has been shown to have numerous positive effects on stress related issues. A study performed in 2005 suggests that massage therapy can, on average, reduce cortisol levels by a whopping 31 per cent. (Field T et al., 2005).

Maintain healthy relationships and minimise arguements

Maintaining generally healthy relationships with relatives and loved ones is another essential step in keeping your cortisol in check for people of all ages. A 2014 study shows that children with a stable and healthy family life have lower levels of cortisol than children who live in families that often argue. (Camelia E. Hostinar et al. 2014). Even couples that have small conflicts have been shown to have a surge in cortisol for a short period immediately after an argument.

Support and empathy seem to be essential qualities that a couple need to have for reducing cortisol. A 2016 study suggests that empathy expressed by a partner quickly helped their significant other’s cortisol levels even out. The same study showed that a supportive partner managed to reduce public speaking related cortisol levels for men. (Laurent HK et al., 2016).

Spirituality

Spirituality can also reduce cortisol levels according to several studies. A study performed on over 90 females showed that being involved in a faith-based group regulated cortisol levels and reduced anxiety and stress. (Dedert et al., 2004) A similar study performed on patients infected with HIV showed a decrease in cortisol levels for those who participated in faith-based groups or simply expressed their faith. The results are particularly important as reduced cortisol levels are associated with an improved immune system for the HIV sufferers. (Bormann et al., 2009)

Increase physical contact with others

Even the simple act of kissing can have a positive effect on one’s cortisol levels. Through the use of blood work and an MRI machine researchers showed that kissing helps release oxytocin which in turn plays a role in reducing cortisol levels in healthy adults. (de Boer et al., 2012).

Reducing cortisol can also be as simple as having someone to hug. A 2013 study tested the reaction between cortisol levels and interpersonal communication expressed through a hug. The results showed that the group that was allowed to use hugs to express themselves had significantly lower cortisol that the group who could only use words to communicate. (Hidenobu Sumioka et al, 2013)

Improving Posture Could Reduce Cortisol by 25%

Significant Decrease in Cortisol Levels

Being aware of simple things such as your posture and attitude can make a world of difference as well. Amy Cuddy conducted a Harvard backed study that showed how changing from a low-power position (slouched over, arms crossed, nervous) to a high-power one (confident, straight back, tall) could reduce cortisol levels by a whopping 25 per cent while also increasing testosterone. (Cuddy et al. 2015)

Learn all about power posers for cortisol reduction

Meditation

Meditation is another way to control cortisol levels while also enjoying numerous other health benefits. In a 2015 study, researchers concluded that meditation can have huge benefits including lower blood pressure, cortical thickening, activation of areas of the brain that are associated with attention and emotion regulation and lower cortisol levels. (Buttle H et al., 2015)

Yoga

Yoga is yet another natural way to reduce stress hormones. A Guangzhou Medical University study that looked at the effects of qigong/tai chi on cancer patients concluded that among numerous benefits to the immune system and general levels of fatigue, cortisol levels were also significantly reduced. (Zeng Y et al., 2014).

Get Better Sleep

Getting a good night’s sleep is perhaps the simplest and one of the most effective ways of lowering cortisol levels naturally. Research shows that even partial sleep deprivation can lead to an increase in cortisol levels of 45 per cent and disrupt daily hormone patterns. (Leproult et al., 1997).

Severe cases of insomnia have been shown to cause increased cortisol levels that last up to and exceeding 24 hours. (Spreng M et al., 2004)

Healthy cortisol levels can be obtained naturally in a number of ways, from extremely simple ones like sleeping or having pleasant interactions to meditation, yoga and complex nutrition. Besides reducing stress and improving general well-being, maintaining a balanced cortisol level provides a series of benefits that are easily achievable for just about anyone willing to follow some simple life-style rules.

Supplements that reduce cortisol

Relacore stress reduction reduce cortisol supplement

The methods described above are easy to follow and should be your first port of call for reducing cortisol. However, if stress is having an immediate negative effect on your life it could be worth taking a supplement designed to reduce your cortisol levels.

Go here to see the best cortisol reduction supplements

References and further reading

  1. Iranmanesh, A., Lawson, D., Dunn, B., & Veldhuis, J. D. (2011). Glucose Ingestion Selectively Amplifies ACTH and Cortisol Secretory-Burst Mass and Enhances Their Joint Synchrony in Healthy Men. The Journal of Clinical Endocrinology and Metabolism, 96(9), 2882–2888. http://doi.org/10.1210/jc.2011-0682
  2. Gyllenhammer, L. E., Weigensberg, M. J., Spruijt-Metz, D., Allayee, H., Goran, M. I., & Davis, J. N. (2014). Modifying Influence of Dietary Sugar in the Relationship Between Cortisol and Visceral Adipose Tissue in Minority Youth. Obesity (Silver Spring, Md.), 22(2), 474–481. http://doi.org/10.1002/oby.20594
  3. Tryon, M. S., Stanhope, K. L., Epel, E. S., Mason, A. E., Brown, R., Medici, V., … Laugero, K. D. (2015). Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body. The Journal of Clinical Endocrinology and Metabolism, 100(6), 2239–2247. http://doi.org/10.1210/jc.2014-4353
  4. Delarue J, Matzinger O, Binnert C, Schneiter P, Chiolero R, Tappy L. Fish oil prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab. 2003;29:289–295.
  5. Barbadoro P, Annino I, Ponzio E, Romanelli RML, D’Errico MM, Prospero E, Minelli A. Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. Mol Nutr Food Res. 2013;57:1110–4. doi: 10.1002/mnfr.201200676
  6. Nieman D. C. et al. Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery. J. Proteome Res. 14, 5367–5377 (2015).
  7. Steptoe A., Gibson E.L., Vuononvirta R., Williams E.D., Hamer M., Rycroft J.A., Erusalimsky J.D., Wardle J. The effects of tea on psychophysiological stress responsivity and post-stress recovery: A randomised double-blind trial. Psychopharmacolog. 2007;190:81–89. doi: 10.1007/s00213-006-0573-2. 
  8. Maresh CM, Whittlesey MJ, Armstrong LE, Yamamoto LM, Judelson DA, et al. (2006) Effect of hydration state on testosterone and cortisol responses to training-intensity exercise in collegiate runners. International journal of sports medicine 27:765–770. 
  9. Martin FP, Rezzi S, Pere-Trepat E, Kamlage B, Collino S, Leibold E, Kastler J, Rein D, Fay LB, Kochhar S. Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects. J Proteome Res 2009;8:5568–79.
  10. Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015). Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology, 232(10), 1793–1801. http://doi.org/10.1007/s00213-014-3810-0
  11. Perna, F.M. & McDowell, S.L. Int. J. Behav. Med. (1995) 2: 13. doi:10.1207/s15327558ijbm0201_2
  12. Anderson, T., Lane, A.R. & Hackney, A.C. Eur J Appl Physiol (2016) 116: 1503. doi:10.1007/s00421-016-3406-y
  13. Perna, F.M. & McDowell, S.L. Int. J. Behav. Med. (1995) 2: 13. doi:10.1207/s15327558ijbm0201_2
  14. Koelsch, S., Fuermetz, J., Sack, U., Bauer, K., Hohenadel, M., Wiegel, M., … Heinke, W. (2011). Effects of Music Listening on Cortisol Levels and Propofol Consumption during Spinal Anesthesia. Frontiers in Psychology, 2, 58. http://doi.org/10.3389/fpsyg.2011.00058
  15. Field T., Hernandez-Reif M., Diego M., Schanberg S., Kuhn C. Cortisol decreases and serotonin and dopamine increase following massage therapy. Int. J. Neurosc. 2005;115:1397–1413. doi: 10.1080/00207450590956459.
  16. Hostinar, C. E., & Gunnar, M. R. (2013). Future Directions in the Study of Social Relationships as Regulators of the HPA Axis across Development. Journal of Clinical Child and Adolescent Psychology : The Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 42(4), 564–575. http://doi.org/10.1080/15374416.2013.804387
  17. Laurent HK1, Hertz R2, Nelson B3, Laurent SM2. Mindfulness during romantic conflict moderates the impact of negative partner behaviors on cortisol responses. Horm Behav. 2016 Mar;79:45-51. doi: 10.1016/j.yhbeh.2016.01.005. Epub 2016 Jan 19.
  18. Dedert E. A., Studts J. L., Weissbecker I., Salmon P. G., Banis P. L., Sephton S. E. (2004). Religiosity may help preserve the cortisol rhythm in women with stress-related illness. Int. J. Psychiatry Med. 34, 61–77. 10.2190/2Y72-6H80-BW93-U0T6
  19. Bormann, J. E., Aschbacher, K., Wetherell, J. L., Roesch, S., & Redwine, L. (2009). Effects of faith/assurance on cortisol levels are enhanced by a spiritual mantram intervention in adults with HIV: A randomized trial. Journal of Psychosomatic Research, 66(2), 161–171. http://doi.org/10.1016/j.jpsychores.2008.09.017
  20. de Boer A., Van Buel E., Ter Horst G. (2012). Love is more than just a kiss: a neurobiological perspective on love and affection. Neuroscience 201 114–124. 10.1016/j.neuroscience.2011.11.017
  21. Sumioka, H., Nakae, A., Kanai, R., & Ishiguro, H. (2013). Huggable communication medium decreases cortisol levels. Scientific Reports, 3, 3034. http://doi.org/10.1038/srep03034
  22. Review and Summary of Research on the Embodied Effects of Expansive (vs. Contractive) Nonverbal Displays; Dana R. Carney, Amy J. C. Cuddy, Andy J. Yap; Psychological Science Vol 26, Issue 5, pp. 657 – 663First published date: April-03-2015 10.1177/0956797614566855
  23. Buttle, H. (2015). Measuring a Journey without Goal: Meditation, Spirituality, and Physiology. BioMed Research International, 2015, 891671. http://doi.org/10.1155/2015/891671
  24. Zeng Y, Luo T, Xie H, Huang M, Cheng ASK. Health benefits of qigong or tai chi for cancer patients: a systematic review and meta-analyses. Complement Ther Med. 2014;22(1):173–86. doi: 10.1016/j.ctim.2013.11.010.
  25. Beaven C, Hopkins W, Hansen K, Wood M, Cronin J, Lowe T. Dose effect of caffeine on testosterone and cortisol responses to resistance exercise. J Sport Nutr Exerc Metab. 2008;18(2):131–141.
  26. Lovallo, W. R., Whitsett, T. L., al’ Absi, M., Sung, B. H., Vincent, A. S., & Wilson, M. F. (2005). Caffeine Stimulation of Cortisol Secretion Across the Waking Hours in Relation to Caffeine Intake Levels. Psychosomatic Medicine, 67(5), 734–739. http://doi.org/10.1097/01.psy.0000181270.20036.06
  27. Badrick, E., Bobak, M., Britton, A., Kirschbaum, C., Marmot, M., & Kumari, M. (2008). The Relationship between Alcohol Consumption and Cortisol Secretion in an Aging Cohort. The Journal of Clinical Endocrinology and Metabolism, 93(3), 750–757. http://doi.org/10.1210/jc.2007-0737
  28. Spreng M. Noise induced nocturnal cortisol secretion and tolerable overhead flights. Noise Health. 2004;6(22):35–47. 

Setipiprant for hair loss: How Exactly Does it Work?

Setipiprant for hair loss

Setipiprant is a relatively new drug in the world of hair loss medications. It’s taken orally and is known as a prostaglandin D2 receptor (PGD2R) antagonist. Prostaglandin D2 is a lipid compound that has hormone like effects in mammals. So a prostaglandin D2 receptor antagonist prevents PGD2 from being effective in the body (or locally in the scalp), thus preventing hair loss.

Have you tried Setipiprant?

It has been shown that inducing wounding in the skin can increase hair growth in mice, and that resistance to PGD2 can promote hair regrowth. According to a 2012 study titled Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44:

Using wound-induced hair follicle neogenesis (WIHN) as a marker of skin regeneration, we hypothesized that PGD2 decreases follicle neogenesis. PGE2 and PGD2 were elevated early and late respectively during wound healing… Additionally, an alternatively spliced transcript variant of Ptgds missing exon 3 correlated with high regeneration in mice. …Furthermore, Gpr44 null mice were resistant to PGD2-induced inhibition of follicle neogenesis. In all, these findings demonstrate that PGD2 inhibits hair follicle regeneration through the Gpr44 receptor and imply that inhibition of PGD2 production or Gpr44 signaling will promote skin regeneration.

Is Setipiprant safe?

Setipiprant seems to be well tolerated by the body, according to a 2014 study focusing on side effects and tolerable levels in the human body. The study was titled Single- and multiple-dose tolerability and pharmacokinetics of the CRTH2 antagonist setipiprant in healthy male subjects, and showed that setipiprant was able to be used in human studies with minimal adverse effects.

Setipiprant was well tolerated after single- and multiple-dose administration. Headache was the most frequently reported adverse event. No treatment effect on tolerability variables was observed. After single- and multiple-dose administration, setipiprant was rapidly absorbed and followed a biphasic elimination pattern with an elimination half-life between 10 and 18h. Steady-state conditions were reached after 2-3 days and setipiprant did not accumulate. Exposure to setipiprant was lower in the presence of food. Urinary excretion of unchanged setipiprant did not exceed 7% of the administered dose. In this entry-into-human study, setipiprant showed good tolerability and a favorable PK profile, thus warranting its development in the treatment of inflammatory disorders.

How effective is setipiprant?

Setipiprant is currently going through a Phase 2A Study to test it’s efficacy. It is believed that the pills in 1000mg potency, twice daily, will help alleviate male pattern hair loss. It is not certain what the effects of the pill would be for women, and the Phase 2A Study has not yet concluded.

The study has an inclusion criteria that the “Participant has androgenetic alopecia (AGA) [and] Participant agrees to maintain current hair care regimen, refraining from hair weaving, hair colorants or dyes and non-study hair growth products during the study.” However, those who have hair loss for other reasons besides Male Pattern Baldness were excluded from the study. Other exclusionary criteria would be damage or scarring of the scalp, and taking of drugs that would impact hair growth within 6 months of the study.

It is unknown if the pills will increase hair growth, but there is promise behind the study. The Phase 2A study is not supposed to conclude until June of 2018, and includes 169 subjects, including placebo controls. Hopefully when the study results are posted, we will find out the efficacy of this growing new hair loss drug.

Increasing subcutaneous fat in the scalp to increase hair growth

Click here to read the quick summary of how increasing subcutaneous fat can promote hair growth.

  • There’s a theory floating around the hair loss forums that there’s a link between subcutaneous fat in the scalp and hair loss. In other words, hair needs subcutaneous fat in order to grow.
  • As men age we lose subcutaneous fat. The theory is the subcutaneous fat loss in the scalp is the primary cause of hair loss and that DHT actually causes the loss of subcutaneous fat in the scalp and that is why we lose their hair in the familiar pattern
  • It is true that men tend to have less subcutaneous fat than women and members of the hair loss forums often report that their scalps feel tight, suggesting they have very little subcutaneous fat in their scalps. However, this tightness could be explained by fibrosis and/or inflammation
  • The theory does make a lot of sense. I found a few quotes from some posters on regrowth.com:

    The thickness of the dermis, hypodermis and galea capitis of the scalp skin varied with gender and age of subject. The thickness of the epidermis, dermis and hypodermis in a balding subject was significantly decreased by comparison with those in a normal subject. (Hori H, Moretti G, Rebora A, Crovato F. The thickness of human scalp: normal and bald. J Invest Dermatol. 1972 June; 58(6):396-9).

    The enhancement of subcutaneous fat in areas associated with increased hair growth is highly significant. Male pattern baldness is intimately associated with a dramatic reduction in the amount of subcutaneous fat associated with hair follicles that are nonproductive. Conversely, during periods of rapid hair growth in mammals, the subcutaneous fat content increase two- to threefold.
    http://www.regrowth.com/hair-loss-forums/topic/subcutaneous-fat-good-fat-under-the-skin-stores-energy/

  • So the key question then is, how do we increase subcutaneous fat in the scalp?
  • Paul Taylor from HairGrowthSOS suggests Omega 3s could help:

    The omega 3 fish oils, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acids) have been associated with BAT activity. So, it may be that, by consuming a very high omega 3 diet, you can do something to help your hair grow.
    Perhaps the best evidence for this idea comes from the Inuit people (Eskimos) who consume extremely high levels of omega 3 fish oils from their diet, and have a very low incidence of androgenetic alopecia.

Subcutaneous fat

Something seemingly hugely significant has been noted in the hair loss community in recent years (yet seems to have remained quite under the radar) — that people who are losing their hair tend to have much less fatty tissue in the area of the scalp that is experiencing hair loss.

It’s believed the effects of DHT on the scalp can cause fat to shift to other locations. The result of this may be severe nutrient restriction to the hair.

A study from June 2017 by the title Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness:

“This follicular regenerative approach is intriguing and raises the possibility that one can drive or restore the hair cycle in male and female pattern baldness by stimulating the niche with autologous fat enriched with SVF. In this first of a kind patient series, the authors report on the safety, tolerability, and quantitative, as well as photographic changes, in a group of patients with early genetic alopecia treated with subcutaneous scalp injection of enriched adipose tissue. The findings suggest that scalp stem cell-enriched fat grafting may represent a promising alternative approach to treating baldness in men and women.”

This data suggests that injecting belly fat into the scalp can increase hair growth in patients suffering male or female pattern baldness.

But how can you increase subcutaneous fat in the scalp from home?

Many people want to know what they can do at home with this treatment option. Sad to say that really isn’t much one can do without going to a doctor/surgeon. The only way to effectively and safely increase the fat content in the scalp is to get fat injections.

Doctors can take fat from another part of the body and transplant that fat into the scalp. This is usually taken from the abdominal area due to the higher fat content and also because the fat cells belong to the patient, and are therefore more likely to be accepted in the scalp by the body’s immune system.

Adding stem cells to the fat

Before it is injected back into the scalp, the fat is generally foritified with stem cells. These cells are called Adipose-derived regenerative cells, also known as stromal vascular fraction, or SVF. It has been shown through testing that the fortified fat is more effective than fat alone. As the 2017 study as shown:

In this pilot case series, a mean increase of 31 hairs/cm2 of scalp (represents a 23% relative percentage increase) is documented in patients undergoing treatment of fat plus SVF. In comparison, the one subject who had fat alone documented a mean increase of 14 hairs/cm2 of scalp, suggesting that while fat alone may represent an approach for early baldness, addition of SVF may enhance this response.

Surely anyone could do this at home?

If you’re prepared to do a bit of DIY surgery it should be relatively easy to perform this operation on yourself. All it requires is a needle and some knowledge about locating subcutaneous fat for extraction and knowing where it needs to be injected into the scalp.

Essential Fatty Acids

A November 2012 study titled Unraveling hair follicle-adipocyte communication, mentioned that mice with lesser fat in their tissues experience hair loss.

“Mouse models with defects in intradermal adipocytes have been reported. For instance, transgenic mice overexpressing human apolipoprotein C-I in the skin, fatty acid transport protein (FATP)-4-deficient mice, and Dgat1−/− or Dgat2−/− mice21,22 have decreased intradermal adipose tissue due to defects in lipid accumulation in mature adipocytes. Interestingly, these mice also display abnormalities in skin structure and function such as hair loss”

This shows that skin cells that are devoid of essential fatty acids results is hair loss in otherwise healthy mice. But this is not what we’re talking about here.

References and further reading

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506773/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507425/

FGF9 for Hair Loss: How it Works and How You Can Use It

FGF-9 for hair loss

Recent discussions in the scientific community on stimulating hair growth have revolved around FGF9. So what is this substance, and how does it work?

FGF9, also known as Fibroblast Growth Factor-9‎, is “an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells” and used by specific T-cells in the body. These T-cells are used by the immune system to repair damage to the skin. Early evidence suggests we may be able to use FGF-9’s skin-repairing growth factor to repair dead hair follicles, so that they may be able to grow hair again.

In a 2015 meta-analysis labeled Wound Healing and Skin Regeneration:

They showed that the tail skin of these mutant mice do not close their wounds as efficiently as control tail skin containing hair follicles. However, after an initial lag period, the wound re-epithelializes at the same rate. From these results, it was concluded that hair follicle cells accelerate the onset of wound healing but are not necessary for wound healing. The relevance of hair follicles to wound healing was also shown by a study that investigated the influence of hair cycle stages on the rate of wound healing.

Potential issues with using this as a treatment have to do with these very T-cells. Humans bodies don’t contain as many T-cells, so activating them might not have the desired effects for hair regrowth. There are also some issues with this new treatment not being tested fervently, leaving potential hazards for long-term growth. For instance, in the same 2015 meta-analysis, the researchers mentioned a study stating:

In mice that lack γδ-T cells (Tcrb−/− mice ) or FGF-9 expression specifically in T cells (Lck-Cre:Fgf9fl/fl mice), wound closure occurs normally, while Wnt signaling is abrogated in dermal fibroblasts, resulting in decreased hair neogenesis. These findings showed that the interplay between immune cells and skin fibroblasts recruited to the wound site is essential to the activation of molecular pathways that promote hair follicle regeneration.

This shows that the regrowth of hair follicles relies on the presence of T cells in the skin. However, this does not mean that FGF9 does not work at all, in fact, it may have potential to help the regrowth of hair in areas where hair may be lacking. The main issue comes with how effective this can be in the long term.

Have you used FGF9?

Researchers are focusing on creating FGF9 into a topical solution. This solution can be used to rub on the area where you want more hair, and can make the growth factor more usable by the human skin. According to a report on Nature.com, many researchers were hopeful, but also skeptical:

Topical FGF9 would be catabolized readily in the skin, thus, delivering adequate sustained levels is not a simple task even if FGF9 maintains the same results in humans….FGF9 will not treat the underlying cause of any specific hair disease. Its best use might be in burn scars, for example, where the trauma occurred in the past but is not an ongoing disease.

More research is being done to test what can be done to boost the effectiveness of this growth factor. There is potential that this can, in the very least, help promote hair growth alongside other topical solutions on the market today designed to stop hair loss.

How can you use FGF9 to increase hair growth?

As a result of the growing demand of the growth factors in hair growth, many companies have been adding what are called Human Fibroblast Conditioned Media (HFCM) into their products. One company that was known to add them in is Cygenx, who sells RegenRXx Hair Serum 90. These are a group of many growth factors that may or may not promote hair growth.

Most of these are topical solutions that you apply to your scalp. If it’s a topical solution you should apply the solution to your scalp, and rub it in for several minutes to ensure deep penetration into the skin and follicles. Afterwords, leave it in your hair for up to 8 hours without washing it. This is to ensure that you get maximum potential from the product.

However, it doesn’t seem like there are many easy to find products that contain this specific growth factor. While you can buy the factor is a more pure form from some websites, it is unclear whether it is effective in that form.

A quick search in Amazon brings up a few products containing FGF9, specifically for treating hair loss. Whether these products work is impossible to say at this stage.

References and further reading

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292081/
  2. http://www.nature.com/scibx/journal/v6/n24/full/scibx.2013.590.html
  3. https://www.ncbi.nlm.nih.gov/pubmed/10362017

Ramatroban for hair loss: everything you need to know

Ramatroban

When it comes to scientific evidence in support of Ramatroban for hair growth, very little exists. While it is becoming a more popular hair growth formula, researching various scientific journals comes up with only a few finds.

Ramatroban is “an orally-active, dual Gpr44 and thromboxane A2 receptor antagonist” which was developed in Germany. It is currently only released in Japan for use as a treatment to allergic rhinitis, or hayfever.

While there is very little empirical evidence of Ramatroban helping reduce hair loss or increase hair growth, there is likely to be some benefit because of it’s role as a Gpr44 Antagonist. According to a 2012 study by the title Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44:

In addition to previous studies suggesting that Gpr44 antagonists may be beneficial in androgenetic alopecia, our results suggest that formulations of Gpr44 antagonists may decrease scarring during wound healing. A specific example is ramatroban, an orally-active, dual Gpr44 and thromboxane A2 receptor antagonist, which is approved in Japan for the treatment of allergic rhinitis in humans Future studies could examine the effect of ramatroban in stimulating hair follicle neogenesis.

Based on what we know so far, what role does Gpr44 antagonists have when it comes to hair loss and potential hair regrowth? Well, according to the evidence, the role of Prostaglandin D2 (a lipid-like compound that has a hormone-like effect in mammals) works to inhibit hair lengthening. Gpr44 is one of the receptors of Prostaglandin D2. Researching the effects of Prostaglandin in body tissues proves difficult due to the fact that it seems to have different effects depending on the tissue that it is in.

According to a 2014 study by the name Does Prostaglandin D2 hold the cure to male pattern baldness?:

Recently, however, work from our group and others have added to the understanding of AGA and suggested novel therapies. We have demonstrated that Prostaglandin D2 is elevated in male balding scalp and that it functionally inhibits hair lengthening through its receptor GPR44, which directly suggests treatments for male pattern hair loss.

This information has been vital in research regarding what is known as androgenetic alopecia (AGA). AGA is generally thought to result from DHT as one ages. Evidence has shown, however, that prostaglandin D2 was higher in those who are bald as opposed to those who had hair. This shows that prostaglandin D2 is thought to prevent the growth of hair, thus causing baldness.

There have been studies that researched the mechanisms that prostaglandin D2 play in accordance to male pattern baldness. According to the 2012 study Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia:

The mechanisms for decreased hair growth in this disorder are unclear. We show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA. The product of PTGDS enzyme activity, prostaglandin D2 (PGD2), is similarly elevated in bald scalp. During normal follicle cycling in mice, Ptgds and PGD2 levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth.

This research concludes that “PGD2-GPR44 pathway as a potential target for treatment.”, meaning that Ramatroban, which is a Gpr44 antagonist, may play a role in the potential for hair growth. However, there is very little evidence linking the two together at this time. There is, however, future studies to be placed in order to research this claim.

Increasing Lactate in the Scalp to Stop Hair Loss and Increase Hair Growth

Researchers from UCLA’s Eli and Edythe Broad Centre of Regenerative Medicine and Stem Cell Research have provided a new solution to this problem by controlling the levels of lactate in the scalp and by developing medicines that regulate lactate levels (Can Stem Cells Finally Solve Hair Loss?, 2015)

Their study proved that there is a direct correlation between lactate production and hair growth

Hair follicle stem cells are responsible for the growth of new hair when they are in the anagen phase. They undergo various metabolic processes including the metabolism of glucose. The metabolized glucose is either converted to pyruvate and transferred to mitochondria for energy production or is converted to lactate. The team at UCLA limited the entry of pyruvate into the mitochondria and saw if this act will increase conversion to lactate, trigger activation of HFSCs and promote hair growth. Their study proved that there is a direct correlation between lactate production and hair growth. Two drugs namely RCGD423 and UK5099 are developed using this study.

Further evidence in this support is shown by Lowry who stated: ‘Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect.’(New way to activate stem cells to make hair grow, 2017). Another research shows that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. Furthermore, lactate generation appears to be critical for the activation of HFSCs as deletion of lactate dehydrogenase prevented their activation (Flores, et. al., 2017). The inclusion of lactate in the hair products is further evidence of the impact of lactate on hair growth (Gavazzoni Dias, 2016).

References

  1. Can Stem Cells Finally Solve Hair Loss? (2015). Wall Street Pit. Retrieved from http://wallstreetpit.com/113981-stem-cells-finally-solve-hair-loss/
  2. Flores, A., Schell, J., Krall, A. S., Jelinek, D., Miranda, M., Grigorian, M., … & Graeber, T. (2017). Lactate dehydrogenase activity drives hair follicle stem cell activation. Nature cell biology, 19(9), 1017-1026.
  3. Gavazzoni Dias, M.F. (2015). Hair cosmetics: an overview. International Journal of Trichology. 7(1), 2-15.
  4. New way to activate stem cells to make hair grow. (2017). Science Daily. Retrieved from https://www.sciencedaily.com/releases/2017/08/170814134816.htm

6 Shampoos that Contain Ketoconazole — which is the best?

Click here to reveal the expert guide to the best ketoconazole shampoo for fighting hair loss and dandruff, or scroll down to view all shampoos.

  • Nizoral (see below) is the shampoo with the highest concentration of ketoconazole (2%)
  • Male pattern hair loss is caused by the hormone DHT. Ketoconazole is believed to reduce DHT in the scalp
  • If you have dandruff or male pattern baldness use Nizoral twice a week.
  • Massage the shampoo into your scalp and leave for 2 minutes before rinsing. Rinse Well…
  • The active ingredient, ketoconazole, is toxic. At 2% it’s not harmful, so don’t worry, but don’t over use the shampoo or leave it on your scalp for more than 2 minutes
  • If you have hair loss that is not caused by DHT, use a milder shampoo with less ketoconazole (see the list of shampoos below). Please note: manufacturers change their ingredients from time to time and some shampoos on this list may no longer contain ketoconazole. Check the ingredients before you buy.

If you have dandruff one of the best things you can do is start using a shampoo that contains ketoconazole. Most people have heard of Head and Shoulders, which uses zinc to control dandruff, but actually ketoconazole shampoos are more effective at treating scalp conditions. Furthermore, ketoconazole (the active ingredient) is a mild ‘5-alpha-reductase inhibitor’, which may help reduce DHT in your scalp, which in turn may help reduce hair loss in men experiencing male pattern baldness.

Ketoconazole is a toxic chemical at sufficient volumes, but at the small volumes contained in these shampoos it effectively kills the common fungi that cause dandruff.

  • Nizoral Anti Dandruff Shampoo

    Nizoral Anti Dandruff Shampoo

    Around $11 for 3.5oz

    Nizoral is by far the most well-known ketoconazole shampoo. It’s also probably the best because it contains the highest concentration of ketoconazole (2%). You should only use Nizoral 2 or 3 times a week because ketoconazole is a toxic chemical. If you use it too much you may experience mild poisoning.

    • Contains 2% ketoconazole — the highest available concentration and therefore probably the most effective for stopping dandruff and fighting against male pattern baldness.

    Buy online (USA)

    Buy online (UK)

  • DS Laboratories Revita High Performance Hair Growth Stimulating Shampoo

    DS Laboratories Revita Hair Growth Stimulating Shampoo Around $21 for 180ml

    • Contains ketoconazole, which kills the fungi that causes dandruff and other scalp conditions and is thought to promote hair growth in some individuals
    • Contains copper peptides, which may improve absorption of ingredients
    • Contains apple polyphenol, which may improve circulation in the scalp
    • Contains MSM, amino acids and biotin
    • Contains emu oil, which contains nutrients and may help nutrient absorption
    • Contains cysteine, the main component of hair (in terms of amino acid composition)
    • Contains taurine, which together with cysteine is thought to promote hair growth
    • Contains caffeine and carnitine tartrate, which may increase cell energy in scalp, increasing hair growth
    • Contains anti-oxidants, which may help protect cells from free radicals

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Perfect Hair Shampoo Review

    Perfect Hair Anti Hair Loss Shampoo Around $20 for 8oz

    On paper this is a really great shampoo. It contains loads of great ingredients for hair loss prevention (see below), including ketoconazole, which reduces dandruff and scalp conditions and is also a mild 5-alpha-reductase inhibitor. However I have noticed that this shampoo has had some really bad reviews on Amazon, so it’s worth checking those out. Click the blue button to view the Amazon reviews.

    • Contains ketoconazole, which kills the fungus that causes dandruff and other skin conditions and may reduce DHT
    • Contains saw palmetto, which blocks 5-alpha reductase, which may reduce DHT when applied topically
    • Contains emu oil, a mild anti-inflammatory, which may also reduce DHT
    • Contains salicylic acid, which helps keep the pres clear of sebum
    • Contains biotin and horsetail (a source of silica), which are thought to help nourish hair
    • Contains niacin, which may help increase blood circulation to the scalp
    • Contains zinc, which kills the fungus that causes dandruff and other skin conditions
    • Contains pygeum, evening primrose oil and borage oil — all of which help inhibit 5-alpha reductase, thus potentially reducing DHT levels.
    • Contains caffeine, which has been shown in studies to promote hair growth

    Ingredients

    Buy online (USA)

  • Regenepure DR anti DHT ketoconazole shampoo

    RegenePure Doctor Recommended Anti Hair Loss Shampoo Around $28 for 16oz

    Regenpure DR is a really great anti hair loss shampoo. It’s not marketed as an anti-dandruff shampoo, but does contain ketoconazole. This is really a great shampoo for hair loss sufferers, who sometimes have scalp conditions as well as the common causes of hair loss. Regenpure also contains saw palmetto (which may help block DHT in the scalp), zinc (which may help clear up skin conditions), salicylic acid (which helps clear the pores of dirt and sebum), niacin (which may increase blood circulation in the scalp, plus other ingredients that benefit the hair.

    • Contains niacin, which may help increase blood circulation in the scalp
    • Contains ketoconazole, which kills common scalp fungi and may also reduce scalp DHT
    • Contains saw palmetto, which may reduce DHT in the scalp
    • Contains linolenic acid, which may inhibit DHT locally
    • Contains emu oil, which is an anti-inflammatory. DHT is thought to cause inflammation in the scalp, leading to hair loss
    • Contains jojoba oil, which may increase hair growth
    • Contains salicylic acid, which helps clear sebum and dead skin cells from the scalp
    • Contains zinc, which helps reduce fungal infections in the scalp

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Boots Ketoconazolw Shampoo

    Boots Anti Dandruff Shampoo Around GBP 8.19 for 20mg

    This is a bog standard ketoconazole shampoo with no added extras. Only available in the UK.

    • Contains 2% ketoconazole

    Ingredients

  • Ketozal Anti Dandruff Shampoo

    Ketozal Anti-Dandruff Shampoo

    • Contains 2% ketoconazole

    Around $9 for 2.1oz

    Ketozal is a lesser known brand of ketoconazole shampoo. Like Nizoral, it’s nothing special but will do the job just fine.

Which is the best?

I recommend the RegenePure shampoo for anyone who is suffering from hair loss. If you also have a flaky, inflamed, irritated or itchy scalp purchase the RegenePure anti hair loss shampoo with the RegenPure DR scalp treatment with ketoconazole.

The Perfect Hair Shampoo contains all the best possible ingredients for a hair loss shampoo. However, due to its bad reviews I can’t recommend it at this moment. If anyone has any good or bad stories about any of these shampoos please leave a comment.

What else can you do to clear up dandruff and improve scalp condition?

Braggs Organic Apple Cider Vinegar

One of the best natural remedies for dandruff is an apple cider vinegar rinse. This is very easy to do. Simply dilute apple cider vinegar in water in a 1:1 ratio. Then apply the diluted solution to your scalp. Leave for 15 minutes and rinse. Do this every day until the dandruff clears up.

If you use an apple cider vinegar rinse, make sure you use an apple cider vinegar that contain something called “the mother”. This is removed from some apple cider vinegars during the manufacturing process, but is an important ingredient for this rinse.

Ketoconazole shampoo for Hair loss: How Does It Work?

Ketoconazole is an imidazole anti-fungal agent that is also effective in topical applications for treating seborrheic dermatitis and dandruff.  Recently, topical use of 2% ketoconazole shampoo has been reported to have had a clinically therapeutic effect on androgenetic alopecia.

To investigate the possible benefits of 2% ketoconazole shampoo on hair growth in mouse models, a group of Japanese researchers applied ketoconazole or a placebo on the dorsal skin of 7 week-old genetically modified (C3H/HeN) mice after shaving off the hair. The results of this study were published in The Journal of Dermatology in 2005. These results showed that 2% ketoconazole clearly stimulated hair regrowth.

How Ketoconazole Stops Hair Loss and Promotes Hair Regrowth

Anti-inflammatory and Sebum Reduction

A 1998 study published in the Swiss journal, Dermatology, by a group of Belgian researchers compared the efficacies of 2% ketoconazole shampoo and a placebo shampoo mixed with or without 2% minoxidil.

The results showed that both 2% ketoconazole and 2% minoxidil were effective for stimulating hair growth. These topical agents increased hair density as well as the size and population of hair follicles during the anagen phase of the hair growth cycle.

The researchers believed that ketoconazole was able to increase hair growth because of its broad antifungal activities against the microbes colonizing the scalp flora; and its anti-inflammatory properties.

The 2% solution of ketoconazole has been proven to reduce local inflammation on the scalp. This inflammation is mostly caused by colonizing fungi and the immune response to the damage done to hair follicles by androgens such as DHT as well as these causative fungi. Ketoconazole has a direct anti-inflammatory property that can help stop these inflammatory reactions. Such inflammations will definitely reduce the output of the hair follicle cells and, therefore, disrupt the hair growth cycle.

Besides its anti-inflammatory properties, ketoconazole can also reduce sebum production in the scalp. By turning down the secretion of sebum from the sebaceous glands attached to the hair follicles, ketoconazole prevents the skin pores of the scalp from clogging up. It frees the path of hair follicles and provides the right environment for new hair growth.

As an Antiandrogen

Androgenetic alopecia causes hair loss at the crown of the head and temples in men and thinning hair over the entire scalp in women. Eventually leading to full hair loss in men. Hair loss occurs due to an excess of dihydrotestosterone (a derivative of the male hormone testosterone) binding to hair follicles receptors. While testosterone is a hormone associated with men, women also have low levels of testosterone in their bodies. Dihydrotestosterone binds to receptors in scalp follicles, shrinking follicles and making it impossible for healthy hair to survive, according to the American Hair Loss Association. Follicles are the small openings in the skin that produce hair. In our bodies Dihydrotestosterone (DHT) is made from testosterone by an enzyme called 5-alpha reductase (5AR). Ketoconazole, inhibits this enzyme and reduces hair loss as a result.

Consideration

You may notice itching burning or irritation when you first use ketoconazole shampoo. Oily or dry scalp can be seen as well. If the side effects continue inform your doctor.

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/1526623
  2. https://www.ncbi.nlm.nih.gov/pubmed/15863844
  3. Downs M. Nizoral shampoo for hair loss. DERMAdoctor,
    http://www.dermadoctor.com/article_Nizoral-Shampoo-for-Hair-Loss_198.html.
  4. https://www.ncbi.nlm.nih.gov/pubmed/10234078

The World’s Most Beautiful Women… With No Hair

Famous women with hair loss

A digital artist from Paris has used the graphic design program Photoshop to make the world’s most famous women look bald. Jacques Gagne, a graphic designer and artist living in Paris said in explanation of the art,

So much time, attention and money goes into making these women look beautiful. It is the obsession of our time. I asked myself, what if I take away an element of their beauty? Are they still beautiful? Does it matter? Are we correct to be so obsessed?

Gagne explained that it’s important we don’t worship women for their beauty.

To be so superficial makes us shallow, but worse than that; when you see that someone like Kylie Jenner is a billionaire without doing anything except getting some cosmetic surgery, it makes you realize how obsessed our society is with precisely the thing we teach our children to not be obsessed with: that exterior beauty is more important than inner beauty and worse than that, it can be bought and traded as a commodity. I wanted to tear that fecade down, if only for a moment, and show that these women are nothing special. The people who are special are the ambulance drivers who save lives and the teachers who raise and educate generations.

So, what do you think? Are these women still beautiful without any hair?

Beyonce hair loss

Taylor Swift hair loss

Kylie Jenner hair loss

Kim Kardashian hilarious bald picture

Emma Watson hair loss

Jennifer Aniston hair loss

Maralyn Munroe with no hair

Grace Kelly with no hair

Scarlett Johansen hair loss

Jennifer Lopez hair loss

Rihanna Fenty hair loss

What’s the Best Shampoo for Hair Loss | 2018

Click here to reveal the expert guide to the most powerful hair loss shampoo, or scroll down to view all shampoos.

  • Nizoral is probably the best shampoo for male pattern baldness (see below).
  • Nizoral contains 2% ketoconazole — this is a higher concentration of ketoconazole than any other shampoo.
  • Ketoconazole is thought to reduce DHT in the scalp.
  • So if you have male pattern hair loss — the type of hair loss caused by DHT — Nizoral is probably your best bet.
  • If you have diffuse hair loss — which is evenly spread hair loss all over the scalp, you’d be better off using a shampoo that contains ingredients that increase blood circulation in the scalp and nutrients that improve the health of the scalp and hair
  • A shampoo like DS Labs Revita (see below) contains loads of active hair growth ingredients, including:
    • Apple polyphenols, which have been shown to stimulate blood circulation in the scalp in a similar way to minoxidil (the popular topical hair loss ingredient found in Rogaine)
    • Cysteine and taurine — amino acids that have been shown in studies to stimulate hair growth when consumed orally; and
    • caffeine, which one study suggests may reduce DHT around the hair roots
  • So what’s the best shampoo for hair loss?
  • If you have male pattern baldness use Nizoral 2 to 3 times a week
  • If you have diffuse thinning use a shampoo like DS Labs Revita

Full list of the world’s best hair loss shampoos, 2018

There are several other shampoos listed below that are arguably just as good as DS Labs Revita — particularly the top 5 in this list, which are all extremely good shampoos.

  • Nizoral Anti Dandruff Shampoo

    Nizoral
    for male pattern baldness

    Around $11 for 3.5oz

    Please note: Nizoral is only the best shampoo for treating male pattern baldness. This is due to a high concentration of the ingredient ketoconazole. If you don’t have male pattern baldness, you should use one of the other shampoos in this list.

    • Contains 2% ketoconazole — the highest available concentration and therefore probably the most effective for fighting against male pattern baldness.

    Buy online (USA)

    Buy online (UK)

  • Revita hair loss shampoo

    DS Laboratories Revita Hair Growth Stimulating Shampoo

    Around $21 for 180ml

    • Contains ketoconazole, which kills the fungi that causes dandruff and other scalp conditions and is thought to promote hair growth in some individuals. UPDATE: Revita may have changed their formula to no-longer include ketoconazole. Check the website ingredients in your country after clicking the buy button below.
    • Contains copper peptides, which may improve absorption of ingredients
    • Contains apple polyphenols, which may improve circulation in the scalp
    • Contains MSM, amino acids and biotin
    • Contains emu oil, which contains nutrients and may help nutrient absorption
    • Contains cysteine, the main component of hair (in terms of amino acid composition)
    • Contains taurine, which together with cysteine is thought to promote hair growth
    • Contains caffeine and carnitine tartrate, which may increase cell energy in scalp, increasing hair growth
    • Contains anti-oxidants, which may help protect cells from free radicals
    • Contains zinc which helps kill common scalp fungi and may help prevent hair loss

    Ingredients

    Buy online (USA)

    Buy online (UK)

    Buy online (India)

  • Wick and Strom Premium hair loss shampoo

    Wick & Ström Premium Hair Loss Shampoo with Ketoconazole

    Around $16 for 12oz

    • Contains ketoconazole, which kills the fungi that causes dandruff and other scalp conditions and is thought to promote hair growth by inhibiting DHT
    • Contains saw palmetto, which may reduce DHT in the scalp
    • Contains aloe vera, which contains many vitamins and minerals and enzymes that may benefit hair growth
    • Contains niacin, which may help increase blood circulation in the scalp
    • Contains biotin, which may aid in the production of cells in the scalp

    Ingredients

    Buy online (USA)

  • Vitamins Gold Label Hair Growth Shampoo

    Vitamins Gold Label Hair Growth Shampoo

    Around $35 for 10oz

    • Contains aloe vera which, studies show may improve hair/scalp health
    • Contains apple cider vinegar, which is widely thought to improve scalp health by removing common scalp conditions
    • Arginine is an amino acid which may help improve blood circulation
    • Biotin contains sulfur, which is required to make hair keratin
    • Caffeine has been shown in studies to boost hair growth
    • Green tea has been shown to inhibit DHT (the primary cause of male pattern baldness)
    • Vitamin D is essential for hair growth — low vitamin D levels may cause hair loss
    • Saw palmetto is believed to inhibit the production of DHT
    • Caviar extract is rich in protein, vitamins and minerals

    Ingredients

    Buy online (USA)

  • Pura D'Or Hair Loss Shampoo

    Pura D’or Organic Argan Oil Anti Hair Loss Shampoo

    Around $28 for 16oz

    Ingredients

    Buy online (USA)

    Buy online (UK)

    Buy online (India)

  • Lipogaine hair loss shampoo

    Lipogaine Big 3 Premium Hair Loss Prevention shampoo for Men and Women

    Around $25 for 8oz

    Update: having just bought a bottle of this in the UK I’ve noticed it doesn’t contain ketoconazole (so I’ve moved it down the list). I was sure this shampoo contained ketoconazole but it doesn’t in the UK. Maybe it does in the United States?

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • RegenePure NT Anti Hair Loss Shampoo

    RegenePure NT Nourishing Treatment Hair Loss Shampoo

    Around $20 for 8oz

    Ingredients

    Buy online (USA)

    Buy online (UK)

    Buy online (India)

  • Hair Growth Cayenne and Saw Palmetto Shampoo

    Hair Growth Cayenne and Saw Palmetto Shampoo

    Around 33 GBP for 10.2oz

    Ingredients

    Buy online (USA)

  • Strong Hair Pro hair loss shampoo

    Strong Hair Pro hair loss shampoo

    Around $16 for 12oz

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Follione Shampoo for hair loss

    FolliOne Shampoo for Hair Growth and Recovery

    Around 10 GBP for 259g

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Revivigen Bio Cleansing Hair Loss Shampoo

    Revivogen Bio-Cleansing Shampoo For Fine And Thinning Hair

    Around $37 for 360ml

    • Contains zinc which helps kill common scalp fungi and may help prevent hair loss
    • Contains azelaic acid, which is thought to inhibit DHT production in the scalp
    • Contains niacin, which may help increase blood circulation in the scalp
    • Contains saw palmetto, which may help inhibit DHT in the scalp

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • FAST Hair Growth Accelerating Shampoo

    FAST Hair Growth Accelerating Shampoo Around $15 for 12oz

    • Contains pantenol, inositol, cysteine, biotin and methionine, which may help feed the hair

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Majestic Coffee hair loss shampoo

    Majestic Pure Coffee Hair Loss Shampoo

    Around $14 for 8oz

    • Strong evidence suggests caffeine promotes hair growth. This shampoo’s main ingredient is coffee.
    • Coffee is a natural source of anti-oxidants, which scavenge free-radicals, protecting the cells in the scalp

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Nisim New Hair Biofactors Shampoo

    Nisim New Hair Biofactors Shampoo Around $35 for 33oz

    Buy online (USA)

    Buy online (UK)

  • Natur Vital Shampoo for hair loss

    Natur Vital Hair Loss Shampoo Around $13 for 300ml

    • Contains pro-vitamin B5 and vitamins A, B3, B7, E, F, H, H1
    • Contains nutrients from germinated wheat
    • New improved organic formula

    Buy online (USA)

    Buy online (UK)

  • Mirage Anti Hair Loss Shampoo

    Mirage Anti Hair Loss Shampoo Around $15 for 10.5oz

    • Contains a good number of natural ingredients and vitamins including: A, B1, B2, B3-Niacin, B5, B6, B12, C-Ascorbic Acid, D, E and K
    • Contains nettle, which may inhibit DHT

    Buy online (USA)

  • Sebamed Anti-Hair loss Shampoo

    Sebamed Anti-Hair loss Shampoo Around $19 for 200ml

    • Contains ginkgo biloba and niacin, which may increase blood circulation in the scalp
    • Contains caffeine, which may help increase circulation and energize cells to increase hair growth

    Buy online (USA)

    Buy online (UK)

Poll: What do you think is the best hair loss shampoo?

What's the best hair loss shampoo?

What’s the best hair loss shampoo for men?

Nizoral Ketoconazole Shampoo

Most men’s hair loss is caused by testosterone interacting with 5-alpha reductase, which produces DHT. We know that reducing DHT reduces hair loss, so as a man the best thing you can do is get a shampoo that reduces DHT.

Increased scalp DHT seems to result increased scalp inflammation, which may be one of the reasons DHT causes hair loss. So you also want a shampoo that contains ingredients that reduce inflammation, such as peppermint and ketoconazole.

Lipogaine hair loss shampoo

If you’re a man I’d recommend using Nizoral shampoo twice a week because it contains a high concentration of ketoconazole (2%) and something like Lipogaine, Revita or Wick & Strom Apex Crown the other days of the week because they contain a lower concentration of ketoconazole plus loads of other really ingredients.

What are the key ingredients to look for in a good shampoo for hair loss?

Ketoconazole

DS Labs Revita hair loss shampoo

The most effective ingredient against hair loss is ketoconazole. Ketoconazole is an anti-fungal agent commonly used in medicated anti-dandruff shampoo. However, it’s also thought to have DHT blocking properties and is widely used and recommended by hundreds if not thousands of members of the biggest hair loss forums.

The most commonly used ketoconazole shampoo is Nizoral, which should only be used 2 or 3 times a week because it contains 2% ketoconazole. Ketoconazole is actually highly toxic, which is why it kills the bacteria that causes the funghi that causes dandruff. However, it’s not recommended to use it too frequently.

In my opinion a really good compromise is to use DS Laboratories Revita or the RegenePure shampoo, both of which contain lower concentrations of ketoconazole, so can be used daily and also contain several other beneficial ingredients. All of these shampoos are featured at the top of this page, from where you can compare ingredients, prices and weights.

Caffeine

Revita hair loss shampoo

It sounds like a gimmick but actually, studies have shown that topically applied caffeine may help reduce hair loss and even increase hair growth. Even a shampoo like Alpecin may be beneficial. However there’s a shampoo that contains a much higher dose of caffeine, which I’ve featured here on this page (the Majestic Pure Coffee Shampoo).

Of the shampoos on this page The DS Labs Revita shampoo also contains caffeine. In fact Revita contains all the key ingredients for stimulating hair growth, which is why I feature it at the top of my list. However, it is also one of the most expensive shampoos on this list.

The RegenePure, FolliOne and Wick & Strom shampoos also contain caffeine. You can view their full ingredients lists by scrolling up the page.

DHT Blocking ingredients

DHT is the most significant cause of hair loss. It’s the main cause of male pattern baldness, which is the most common form of hair loss. DHT is a by-product of the hormone testosterone (which is why men experience hair loss far more than women). When DHT reaches the hair follicles is causes them to gradually miniaturize, until they become dormant.

There are several natural ingredients that are known to block the conversion of testosterone into DHT and this blocking is the basis of many hair loss treatments. Several ingredients are used in these shampoois to block DHT. If you’re suffering male pattern baldness, look for a shampoo that contains ingredients like:

I also recommend taking a look at my lists of the best topical DHT blockers and the best natural DHT blocker supplements.

What else should you look for in a hair loss shampoo?

If you want to fight hair loss and help your hair grow you want a shampoo that contains ingredients that improve circulation in the scalp, such as niacin. You also need a shampoo that cleanses your scalp well, otherwise pores may become blocked, leading to hair loss — ingredients like salicylic acid help with this. Finally, you should look for ingredients that reduce DHT in your scalp because DHT causes hair loss. These are the primary three concerns. After that you can start to look for shampoos containing nutrients that help feed your hair or energize cells in the scalp.

What to avoid in a shampoo

You need a shampoo that cleanses your scalp well, but you should avoid shampoos with harsh chemicals like “sodium lauryl sulfate” — this is like a bleach, which after years of use may cause hair follicle miniaturization and may also be toxic if absorbed through your skin (though in small doses is safe). See organic shampoos that don’t contain sodium lauryl sulfate for more information.

My review of hair loss shampoos — what is the best shampoo for hair loss prevention and hair growth promotion?

I’ve listed above some of the best hair loss shampoos available. Where I’ve listed the benefits and drawbacks for each shampoo I have listed ALL the benefits and ALL the drawbacks (as far as I can see). So if there’s only one benefit, there’s only one benefit — likewise with the drawbacks. If you want me to look at any other shampoos, let me know in the comments.

DS Laboratories Revita High Performance Hair Growth Stimulating Shampoo

In my opinion the best shampoos out there are DS Laboratories Revita Hair Growth Stimulating Shampoo, RegenePure and Wick & Strom. DS Labs Revita shampoo ticks almost all the boxes. However, it’s very expensive. If $25 is a bit excessive (which it probably is for most people), you might be better off going for a natural or even organic shampoo that is isn’t specifically labelled as a hair loss shampoo. The problem with a lot of hair loss shampoos is they contain ingredients that may help promote hair growth, but to save money they’ve used cheap base ingredients like sodium lauryl sulphate.

So if you’re not prepared to pay for the DS Labs Revita shampoo or any of my other top 5, it’s probably worth taking a look at my list of organic shampoos, which are cheaper and also contain many beneficial ingredients.

It’s also worth checking out my list of ketoconazole shampoos, which contain a higher concentration of ketoconazole and my list of anti-DHT shampoos, which are specifically forumalted to block DHT.

Questions, Recommendations, Suggestions?

If you have a question, have seen an error or you know of a shampoo you think should be listed here, please post a reply using the link below.

Equol for Hair Loss: All the Evidence that it Works

Equol hair supplements

Dihydrotestosterone (DHT), which is a more potent form of testosterone has been shown to be closely linked with male pattern baldness. Many attempts have been taken to keep this hormone in check and control the resulting hair loss, but the approved medication, Propecia, has considerable side effects.

What is equol?

The clinical effectiveness of soy isoflavones may be a function of the ability to bio transform soy isoflavones to the more potent estrogenic metabolite, equol

Equol is identified as a metabolite of soy isoflavones, daidzin and daidzein in the human urine and is produced by the intestinal bacteria in some individuals. The clinical effectiveness of soy isoflavones may be a function of the ability to bio transform soy isoflavones to the more potent estrogenic metabolite, equol, which may enhance the actions of soy isoflavones, owing to its greater affinity for estrogen receptors, unique antiandrogenic properties, and superior antioxidant activity.

Anti androgen properties

it is evident that equol not only fights against hair loss but also promote hair growth

The antiandrogenic properties of equol makes it an effective chemical to stop hair loss because it blocks Dihydrotestosterone. What make this substance more beneficial than other antiandrogens is the fact that it binds directly to DHT and inactivates it without influencing testosterone. Soybean extracts have been found to affect not only hair pigmentation, but also the rate of hair growth, the dimensions of the hair follicle and hair shaft, and the appearance of the hair. So it is evident that equol not only fights against hair loss but also promote hair growth.

However not all individuals can produce equol. Only approximately one-third to one-half of the population is able to metabolize daidzein to equol. This is due to the differences in the microflora of different individuals. However research has indicated that short-term administration of soy isoflavones stimulated the production of serum equol and decreased the serum DHT level in healthy Japanese volunteers. These results suggest the possibility of converting equol non-producers to producers by prolonged and consistent soy isoflavones consumption. The time is not far when everybody can benefit from this amazing chemical agent.

References

  1. Seiberg, M., Liu, J. C., Babiarz, L., Sharlow, E., & Shapiro, S. (2001). Soymilk reduces hair growth and hair follicle dimensions. Experimental dermatology, 10(6), 405-413.
  2. Tanaka, M., Fujimoto, K., Chihara, Y., Torimoto, K., Yoneda, T., Tanaka, N., Hirayama, A., ….Hirao, Y. (2009). Isoflavone supplements stimulated the production of serum equol and decreased the serum dihydrotestosterone levels in healthy male volunteers. Prostate cancer and prostatic diseases, 12(3), 247-252.
  3. Yuan, J.P., Wang, J.H., & Liu X. (2007). Metabolism of dietary soy isoflavones to equol by human intestinal microflora -implications for health. Molecular nutrition & food research, 51(7), 765-781.

The Hands Down BEST DHT Blocker Supplements for Hair Loss Prevention

Click here to reveal the expert guide to the most effective DHT blockers, or scroll down to view all.

  • DHT Blockers: The science seems good but can natural DHT blockers like saw palmetto, pygeum and nettle be powerful enough to have a noticeable effect on hair growth like Propecia does
  • Propecia is effective, but I wouldn’t recommend it to anyone. See my article “Should I take Propecia” to see why I would never take it
  • So your next best bet after Propecia is a natural DHT blocker supplement
  • How do you find an effective DHT blocker?
  • There are a few key ingredients you need to look for. If you see all of these ingredients in a supplement, you’ve found a good one:
  • Green tea. Green tea reduces PGD2 in the scalp. This is now thought to be key to stopping male pattern baldness
  • Resveratrol: A study in 2014 and one in 2016 concluded that resveratrol suppresses PGD2-stimulated OPG synthesis through inhibiting p38 MAP kinase and SAPK/JNK in osteoblasts (Kuroyanagi, Gen et al., 2014), as well as the fact that Resveratrol could inhibit PGD2-mediated inflammation. (Devon et al., 2016). Read more here.
  • Quercetin: A study published in 2012 on contact dermatitis and photosensitivity argued that Quercetin can effectively inhibit secretion of histamine and PGD2. When compared to Cromolyn, Quercetin significantly decreased contact dermatitis and photosensitivity and was argued to be a promising candidate as an effective mast cell inhibitor through sufficient oral absorption.
  • Note that resveratrol and quercetin are also powerful natrual antioxidants
  • Large amounts (500mg) of cysteine, lysine and taurine. These amino acids have been shown to increase hair growth in studies.
  • Iron: According to MPB Research,

    virtually all treatments for hair loss in both men and women are more efficacious with iron supplementation, whether you are “iron deficient” or not. Dr. Rushton maintains that this effect is dramatically enhanced when iron is used in conjunction with vitamin C and L-Lysine.

  • Note that soy contains iron. This may be partly why soy isoflavones help reduce hair loss
  • Pygeum: pygeum has DHT blocking effects, similar to Propecia but not as effective:
    In a 2007 study those taking a treatment involving pygeum had 43.3% improvement, comparable to the results for finasteride (57% improvement) Finasteride.
  • Vitamin D3 (unless you already get lots of sunshine)
  • Anti inflammatory ingredients like curcumin, quercetin (also mentioned above). Why? It’s widely speculated that DHT causes serious inflammation in the scalp, which leads to male pattern baldness.
  • Other ingredients worth looking out for include saw palmetto, pumpkin seed oil and capsaicin / cayenne.

The best supplements for blocking DHT

Here are what I consider to be the most effective DHT blocker supplements:

  • Nutrafol Men Advanced Thinning Hair Loss Supplement

    Nutrafol Men Advanced Thinning Hair Loss Supplement

    $88 for 120 Capsules

    Wow, what can I say? This is the best hair loss supplement I’ve ever seen. I’ve been studying the hair growth effects of thousands of different nutrients and this supplement contains almost all the key nutrients that promote hair growth and prevent hair loss. It has the key amino acids, DHT blockers, inflammation reducers, key vitamins and minerals and several other beneficial nutrients. This supplement tops the list but is very expensive. So it’s worth checking out the others on this page (which are also very good) if you don’t want to spend this much.

    • Contains saw palmetto, which has been shown in several small studies to block the enzyme 5 alpha reductase, which effectively reduces DHT levels
    • Curcumin is highly beneficial for reducing inflammation, which is key to preventing progression of male pattern baldness
    • Contains vitamin E, which is beneficial for hair and skin health
    • Contains hyaluronic acid, which may improve skin health
    • Contains cysteine, lysine and methionine — these are three of the 5 key amino acids identified as being effective at increasing hair growth
    • Contain silica, which has been shown to improve health of skin and connective tissue and has been identified as a key nutrient for hair growth
    • Contain resveratrol, a powerful natural antioxidant which has been shown to slow down aging due to antioxidant action on cells
    • Contains Bioperine, a patented form of black pepper, which has been shown in studies to improve nutrient absorption
    • Contains capsaicin (the ingredient which gives chilli peppers their heat), which has been shown to reduce male pattern baldness by increasing dermal IGF-1 — the growth factor required that seems to play an important role in hair growth
    • Contains biotin, which is used by the body to transform amino acids into proteins like keratin, among other functions. It’s therefore vital for healthy hair and skin
    • Contains vitamin D3 is required to regulate calcium levels and plays other important roles in hair growth. Studies show vitamin D deficiency may lead to hair loss
    • Contains fish collagen. This is interesting because it’s similar to shark cartilage used in Nourkrin hair supplements. It’s what Nourkrin say makes their supplements work. However I’ve seen no research to suggest this does work. Still it’s worth a mention because there must be some reason fish/shark meat is used in hair supplements. It may be beneficial due to the amino acid content?

    Ingredients

    Buy online (USA)

  • Advanced trichology dht blocker supplement

    Advanced Technology DHT Blocker with Immune Support
    $36 for 120 Capsules

    This is a superb all round DHT blocker supplement. Not only does it contain a powerful blend of DHT blocker ingredients; it also contains probiotics, which help improve intestinal health and support an alkaline PH level, which may be beneficial for healthy DHT levels.It also contains the amino acid lysine, which studies show, increases hair growth. This is a top DHT blocker supplement.

    Ingredients

    Buy online (USA)

  • Reserveage Keratin Booster with DHT Blockers

    ReserveAge Organics Keratin Booster
    $33 for 60 Capsules

    Next on our list is ReserveAge Organics Keratin Booster, which combines natural DHT blockers with keratin, a nutrient necessary for growing new hair. This supplement is a great option for people who cannot include soy or gluten in their diets, as it is soy and gluten free, as well as organic!

    • Contains high levels of antioxidants, which may benefit hair growth by scavenging free radicals
    • Organic ingredients are richer in minerals

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Hairomega DHT supplement

    Hairomega 3-in-1 DHT blocker $20 for 120 Tablets

    Hairomega’s DHT blocker not only blocks DHT but increases blood flow to the scalp using various polyphenols, which aid in further hair growth once the hair follicles are restored. There are even other beneficial vitamins in the pill for your overall health, making this supplement a fantastic option for a DHT blocker!

    • Contains vitamins and minerals that support hair growth
    • Contains several potent ingredients that are strongly believed to reduce serum DHT, including saw palmetto, pygeum, nettle, green tea and pumpkin seed
    • Contains quercetin, green tea, raspberry and broccoli, which are high in antioxidants
    • Contains mushrooms and herbs, which may benefit hair growth

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Folliform DHT Blocker supplement

    Folliform DHT Blocker for Men and Women
    $29.99 for 60 Capsules

    Folliform DHT Blocker uses saw palmetto, nettle root extract, green tea, pumpkin seed, pygeum extract, and zinc oxide to help with hair growth. These ingredients form a natural DHT blocker, meaning that not only will your hair grow longer, but you’ll also only be adding all-natural ingredients to your body. Many users have seen not only hair growth, but improvement in nail health as well (which is just an added bonus!)

    • All the ingredients used in this supplement are strongly believed to reduce serum DHT
    • Green tea contains antioxidants, which may also be beneficial for hair growth

    Ingredients

    Buy online (USA)

  • Shen Min high stength DHT blocker

    Shen Min DHT Blocker 27.99 for 60 Tablets

    Shen Men DHT Blocker is an all-natural DHT supplement that uses He Shou Wu, a Chinese root that has been shown to aid in blocking DHT in the body as its primary ingredient. Users have noticed fantastic results with this product. Several users reported results within 2-3 weeks, while most seem to see them within a couple of months!

    • Contains a wide variety ingredients that are strongly believed to reduce serum DHT
    • Quercetin is high in antioxidants, which may be beneficial for hair growth
    • He shou wu is a potent Chinese herb that is believed to stop hair loss in some individuals

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • NuHair DHT blocker supplement for men and women

    NuHair DHT Blocker for Men and Woman $18.99 for 42 Capsules

    Like the other DHT Supplements on this list, this is an all-natural DHT blocker that uses soy, saw palmetto extract, and other natural vitamins to block the effects of DHT. Also, like Shen Min DHT Blocker, it uses He Shou Wu to suppress DHT in the body. This product not only helps people who already have bald spots, but people who have noticed that their hair is thin and lacking luster.

    • Provides a good array of anti DHT ingredients
    • Contains He shou wu; a potent Chinese herb that is believed to stop hair loss in some individuals

    Ingredients

    Buy online (USA)

    Buy online (UK)

These highly rated supplements are great options for men looking for a DHT blocker in order to regrow hair. However, like with all nutritional supplements, talk to your doctor before starting any program of supplementation, as you may have a pre-existing condition or medications that may interact with the ingredients found in these supplements.

What is dihydrotestosterone inhibitor?

Dihydrotestosterone (DHT) is an androgen sex hormone. When testosterone combines with an enzyme called 5-alpha reductase in our body, it produces DHT. This compound may cause harm to our body, especially our scalp.

When DHT is in our scalp, it combines with an “androgen receptor” located in the hair follicles, causing the size of the follicles to become smaller, thereby thinning out our hair.

So based on this knowledge, to cure hair loss as a result of DHT production, we need to block the activities of the 5-alpha reductase enzyme. That is to say, we need a DHT blocker.

Ingredients that block DHT

Studies have shown the ingredients below may reduce DHT levels when consumed orally.

Saw Palmetto

Saw palmetto comes from a palm-like plant that grows in the United States. It has been shown to inhibit the activity of 5-alpha reductase enzyme, hence it blocked producing DHT. In a study to compare the effectiveness between saw palmetto and finasterile, the researchers divided the male participants into two groups. The first group received saw palmetto for 2 years. The second group received finasterile for the same period of time. The results showed that the saw palmetto group had an increase in hair growth (1).

Nettle

Nettle is a common weed that has a sting when you touch it. It has the same function as saw palmetto by blocking the activity of 5-alpha reductase enzyme, thus reducing the production of DHT (2).

Pumpkin seed oil

Pumpkin seed oil has been proven to block the activity of 5-alpha reductase enzyme and to have anti-androgenic efficacy on mice. In a clinical trial to discover the effectiveness of pumpkin seed oil for treating male patients with moderate androgenic alopecia, male patients either received pumpkin seed oil or a placebo for 6 months. The research team concluded that the group receiving pumpkin seed oil had more hair than the control group (3).

Rosemary Extract

Besides the other herbs that I described above, rosemary extract is another promising candidate both to add to your diet and to cure hair loss in the long run. It works on inhibiting the 5-alpha reductase activity. A study was performed on mice which were given testosterone to cause hair loss. These mice were treated with rosemary extract. The results showed that the higher the dose of rosemary extract, the less hair loss they had (4).

Green tea

Green tea can be used to treat patients with androgenic alopecia thanks to its mechanism of blocking DHT. Epigallocatechins extracted from green tea leaves had the highest 5-alpha reductase inhibitory ability (5).

Pygeum

Pygeum is known as African plum tree. It is believed to inhibit the 5-alpha-reductase enzyme, thus helping to treat patients with alopecia although there haven’t been any clinical trials so far (6).

An important warning about DHT blockers

If you are a man who wishes to reduce his DHT levels, remember that these supplements may reduce prostate gland size. Why is this important? If you have a prostate examination it’s important that you tell your doctor that you have been using supplements that reduce DHT levels, so that your doctor can take that into account when examining your prostate size.

References and further reading

  1. Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, et al. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. International journal of immunopathology and pharmacology. 2012;25(4):1167-73.
  2. Nahata A, Dixit VK. Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats. Andrologia. 2012;44:396-409.
  3. Cho YH, Lee SY, Jeong DW, Choi EJ, Kim YJ, Lee JG, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-based complementary and alternative medicine : eCAM. 2014;2014:549721.
  4. Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, et al. Promotion of hair growth by Rosmarinus officinalis leaf extract. Phytotherapy research : PTR. 2013;27(2):212-7.
  5. Jain R, Monthakantirat O, Tengamnuay P, De-Eknamkul W. Identification of a new plant extract for androgenic alopecia treatment using a non-radioactive human hair dermal papilla cell-based assay. BMC complementary and alternative medicine. 2016;16:18.
  6. A.G. M. Pygeum and Hair Loss 2017 [Available from: http://www.livestrong.com/article/546657-pygeum-and-hair-loss/

Topical Finasteride Liquid Scalp Tonic Solutions

Topical finasteride scalp solution

Try at your own risk! I recently noticed businesses selling topical Finasteride! Finasteride, commonly known by it’s brand name Propecia, is usually taken in pill form and is a prescription drug. So I’m not sure if these guys are selling a topical containing Finasteride legally, or even if the product really contains Finasteride. So if you decide to try one of these products, try it at your own risk. As far as I know it’s illegal to sell Finasteride without prescription.

If you’re interested in buying the one pictured here, just search eBay for Finasteride.

Topical Finasteride for Hair Growth Promotion and Hair Loss Prevention: Does it Work?

The idea behind Finasteride is that applying the medication to the head, or consuming it orally, reduces dihydrotestosterone (DHT) levels. DHT causes hairs on the head to minaturize over a period of several years until they no longer grow.

According to a 2015 study titled Topical Minoxidil Fortified With Finasteride: An account of maintenance of hair density after replacing oral finasteride:

Of the 45 patients who underwent a continuous treatment for AGA, 84.44% maintained a good hair density with topical minoxidil-finasteride combination.

A systematic review of numerous randomized controlled trials was also conducted in July of 2017, which came back with the following results:

A meta-analysis was conducted separately for 5 groups of studies that tested the following hair loss treatments: low-level laser light therapy in men, 5% minoxidil in men, 2% minoxidil in men, 1 mg finasteride in men, and 2% minoxidil in women. All treatments were superior to placebo (P < .00001) in the 5 meta-analyses”

So according to the data provided by randomized controlled trials as well as other recent studies, topical solutions fortified with finasteride ia deemed effective for reversing hair loss, as well as preventing further hair loss. The FDA supports these findings.

References and further reading

  1. https://www.ncbi.nlm.nih.gov/pubmed/28396101
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314881/

How to Remove DHT from your Scalp and Trigger Sudden New Hair Growth

Have you ever noticed how balding men have incredibly shiny scalps?

That fact is far more important than you might think.

DHT causes fibrosis in your scalp. Fibrosis is basically scarring. When scarring occurs your scalp becomes shiny. And when that happens it means the hair follicles have been destroyed.

In fact, once fibrosis has set in, hair cannot grow. It’s impossible.

Reducing DHT will help prevent further fibrosis from occurring, but it WILL NOT MAKE HAIR GROW BACK.

So what’s the answer?

The answer to making your hair grow back is not just to reduce DHT.

The answer is to REGENERATE YOUR SCALP SKIN.

And that is the genius of this method…

If you want to regrow your hair you MUST heal the fibrosis and inflammation caused by DHT

But more than that. You have to regenerate the scalp skin so new, healthy scalp skin grows, replacing the scarred skin. And the new fibrosis-free skin will contain hair follicles.

This phenomenon has been observed in several studies at major research facilities

This method works by alternating between gently breaking down the scar tissue in the scalp and intensely nourishing it with powerful hair growth nutrients.

By mildly damaging the scalp skin and then flooding the scalp with a special combination of amino acids, antioxidants, vitamins and minerals the scalp begins to heal itself and new hair growth begins.

This phenomenon has been observed in several studies at major research facilities around the world but as far as I’m aware I’m the only person to put this science into a practical method that anyone can use at home on their own, with no scientific equipment needed.

Your skin is an incredibly sophisticated organ that has evolved over millions of years.

Think about this:

Your skin can do something amazing. No other organ in your body can do this. It’s quite remarkable when you think about it:

It can heal itself.

Your skin can rebuild itself. All on its own.

Skin is made of layers of skin cells.

But it also contains the DNA needed to make new hair.

Hair follicles are part of the skin. Therefore, if the skin is damaged it not only regrows skin, it regrows hair follicles!

And that is the key to the method I’m about to show you.

What we’re going to do is use a very simple technique to gently break down the fibrosis. Then we’ll flood your scalp with a special combination of amino acids.

These are the same amino acids that your hair is made of.

Hair is made of keratin. Keratin is made of 9 amino acids and a little bit of sulfur.

I’m going to show you how to flood your scalp with the raw materials it needs to grow new hair.

Then we’re going to break down the old scarred scalp skin, which cannot grow hair.

Then, when the scalp repairs itself, new hair follicles are grown.

As we repeat this process more and more new hair follicles are produced all over the scalp.

If you’re ready to get started click on the get started button to download the instructions.

Download the Hair Regrowth Method

  • Learn how to increase a growth factor in your scalp, causing new hair to grow.
  • Flood your scalp with powerful hair growth nutrients all day, every day with the 2 minute method.
  • Learn how to reduce your cortisol levels, in turn reducing your DHT levels naturally and safely.
Before and after Advanced Hair Research

It’s been a phenomenal feeling to start seeing my hair growing back after years of watching it get thinner.

How we’re going to safely reduce DHT to prevent further fibrosis

As well as showing you how to break down fibrosis in your scalp and initiate new hair growth, I’m going to show you the best possible way to naturally and safely reduce serum DHT. Just take a look at this…

Your hair is being rapidly killed by a common hormone called DHT.

But did you know that high ‘cortisol’ hormone is what causes elevated DHT?

Cortisol is a powerful stress hormone. And when you have high testosterone and high cortisol your body produces high levels of DHT, which makes its way to your scalp, binds to the follicles and gradually ‘kills’ them.

But just look at this…

Without realizing it, you’re daily habits are killing your hair

You’re also ruining your health and making your life much harder than it needs to be. And it’s all because of a minor hormonal imbalance, that you could easily fix!

Your testosterone levels are highest in the morning…

Testosterone by time of day

The morning is also when you’re most stressed: Traffic jams, sub-ways, annoying emails, etc, etc. It’s easy to get angry and stressed in the morning.

So, every morning, you have high testosterone and high cortisol levels.

In other words…

Cortisol graph by time of day

…every morning, your body becomes a hair destroying DHT factory.

Because testosterone + cortisol = DHT…

Chris Carter before and after nicehair

The cortisol graph you see here illustrates typical cortisol levels. However, as someone who experiences hair loss, you likely have higher than normal cortisol, or higher than normal testosterone. Or a combination of the both. For me it was both. Which is why I lost my hair so young and so rapidly. Luckily I was able to get my hair back though (that’s me in the picture).

If you have high cortisol, it’s likely that your cortisol is elevated at night. Which is very bad. It likely means your cortisol chart is consistently elevated, which has bad ramifications for your whole life. If your cortisol is consistently elevated you probably feel tired a lot during the day; you’re probably not achieving the things you want to achieve in life due to low drive — and it means DHT is building up in your scalp day by day, gradually destroying your hair by causing more and more fibrosis.

Cortisol is in essence, a stress hormone. … When we have high levels of cortisol coursing through the body this leads to an increase in adrenaline, testosterone and in particular, a hormone known as dihydrotestosterone or DHT
Dr Seymour Weaver

You’re killing your hair, just by being you!

Through no fault of your own, you’re literally killing your hair every single day. You couldn’t be making your hair any worse if you tried. In fact it’s a wonder you have any hair left at all.

I’m serious. The way you’re living right now is quite simply the worst way to live if you want to keep your hair.

An elegant and powerful solution to this problem…

It’s frustrating for me to see so many people who have adopted lifestyle habits that are so destructive to their health and their hair. Especially when it’s so incredibly easy to fix this simple problem.

All you have to do is get your cortisol levels down as low as possible at night time.

That’s it. By doing so, you’ll sleep more deeply, meaning your body will regenerate more effectively while you sleep. Your brain function will improve. Your stress levels will reduce dramatically. Your focus will improve during the day. You’ll be sharper, better at your job, you’ll have more energy… …and of course your scalp won’t be filled to the brim with hair destroying DHT. You’ll also see improvements in your skin and even your long-term health — studies indicate that the stress hormone is a major contributor to serious illnesses like cancer and heart disease.

Think about the people you know with hair loss. They’re usually the highly stressed ones. Now think about the people you know with thick hair. They’re more often than not the relaxed ones.

And check this out…

Studies have shown that highly successful people like business owners, top athletes and rock stars tend to have very low cortisol levels (and did you notice they also seem to have thick hair into their old age?!) Having low cortisol helps you stay focused and calm in tense situations, enabling you to think clearly and make good decisions.

This is quite simply VITAL, if you want to regrow your hair

Think about it. If you have high cortisol you sleep badly, which is bad for your health. And when you wake up and your testosterone is elevated, the combination of cortisol and testosterone turns your body into a hair destroying DHT factory.

It’s no wonder you’re losing your hair.

How to reduce your cortisol to super healthy levels while you sleep

There’s a remarkable audio program (which comes free with my download linked below), that’s designed to make your cortisol levels as low as possible when you wake. So in the morning, instead of your cortisol peaking out of control, you stay calm, focused and in total control.

The audio uses subconscious binaural rhythms, isotronic tones and subliminal messages to ‘optimize’ your mind to the most perfectly healthy, stress-free calm, deep sleep, enabling your body to maximize regeneration.

Download the Hair Regrowth Method

  • Learn how to increase a growth factor in your scalp, causing new hair to grow.
  • Flood your scalp with powerful hair growth nutrients all day, every day with the 2 minute method.
  • Learn how to reduce your cortisol levels, in turn reducing your DHT levels naturally and safely.
Before and after Advanced Hair Research

It’s been a phenomenal feeling to start seeing my hair growing back after years of watching it get thinner.

What Does DHT Do?

Dihydrotesterone (DHT) is a sex steroid and androgen found in the testes, prostate, adrenal glands and hair follicles. It’s produced by the reaction of the 5-alpha-reductase enzyme with another androgen, testosterone. It’s estimated that about 5% to 7% of the body’s testosterone is converted tpo DHT, with most produced in the prostate gland.

DHT has been shown to be twice as likely to bind with androgen receptors, and five times more adhesive. This matters because DHT has also been shown to be a significant contributor to androgenic alopecia. AGA is the most common form of hair loss and affects both men and women. It’s estimated that by the time they reach 50, over half of American men will suffer from DHT-triggered hair loss.

More androgen receptors in the Scalp = More Hair Loss?

Balding cells contained significantly (P < 0.01) greater levels of androgen receptors (Bmax = 0.06 +/- 0.01 fmol/10(4) cells (mean +/- S.E.M.)) than those from non-balding scalp (0.04 +/- 0.001)

Many of these androgen receptors exist in hair follicles on the scalp. How readily DHT binds to them is partly influenced by genetic factors. Some people have hair follicles which are more susceptible to DHT, and so are more likely to suffer from AGA. This 1998 study showed that the scalps of balding men contain higher levels of androgen receptors than those of non-balding men.

How does DHT cause hair loss?

it prevents the amino acids and minerals needed to nourish the hair from getting through

DHT causes hair loss by disrupting the healthy hair growth cycle. Hair grows during the anagen phase, when the follicles are active. After a brief catagen phase, which allows for follicle renewal, the follicles go through a resting (telogen) phase.

Balding cells contained significantly (P < 0.01) greater levels of androgen receptors (Bmax = 0.06 +/- 0.01 fmol/10(4) cells (mean +/- S.E.M.)) than those from non-balding scalp (0.04 +/- 0.001)

DHT attaches to receptor cells at the root of the hair follicles (the dermal papillae). From here it prevents the amino acids and minerals needed to nourish the hair from getting through. As a result the hair follicles shrink — a process called miniaturization. This leads to a shorter anagen phase and a longer telogen phase. New hair grown from miniaturized follicles is much thinner and shorter. Eventually it stops growing and falls out because the more prevalent telogen hair is less firmly rooted to the scalp.

What Causes DHT To Increase?

The level of DHT in the body is dependent on the levels of free circulating testosterone. As men age their testosterone levels decline, and you might expect DHT levels to decline too. This doesn’t happen though. The reason DHT levels remain the same in older age is explained by the fact that testosterone is converted to a wide variety of byproducts, not only DHT. As the body ages it shifts focus of testosterone conversion away from these other byproducts to maintain normal DHT levels.

Many studies have shown that obese men have much lower levels of testosterone than those with a normal BMI. Reducing your weight can increase levels of testosterone and in turn, DHT. Weight loss also reduces the conversion of testosterone to estrogen, which means there’s more available to be converted to DHT.

Regular exercise will also increase DHT levels. Resistance exercise like weightlifting is good for stimulating testosterone production. While explosive spurts of exercise, such as sprinting, will cause your DHT levels to rocket.

The foods you eat will also affect your DHT. Testosterone production can be stimulated by increasing your carbohydrate intake while restricting protein.

How To Reduce DHT

Finasteride/Propecia

Finasteride

DHT levels can be reduced by medical means. Propecia (Finasteride) is one of only two FDA-approved drugs for hair loss. It blocks DHT production by inhibiting 5-alpha-reductase from reacting with free testosterone. By taking Propecia circulating levels of DHT can be decreased by 65% to 98%. This 1998 study concluded that 1mg pill taken daily could slow hair loss and increase hair regrowth. Once treatment stops, hair loss will resume.

DHT Blocker Supplements

DHT blocker supplements

There are hundreds of DHT blocker supplements available online. These supplements contain natural plant extracts that have been shown in studies to reduce DHT levels. The best ingredients to look for in DHT blocker supplements are:

Take a look at the best DHT blocker supplements here.

Topical DHT Blockers

Topical DHT blockers

You can apply the above ingredients to the scalp using topical solutions or oils such as pumpkin seed oil (see below). Less research has been conducted on topical use of extracts like saw palmetto, but there’s is a reasonable amount of investment in topical DHT blockers.

Find out more about topical DHT blockers here.

DHT Blocker Shampoo

Best anti DHT shampoos

As well as using a topical leave in scalp treatment, there are many shampoos that claim to block DHT. I’ve listed what I consider to be the best DHT blocker shampoos here.

It worth noting that ketoconazole is thought to be a good topical DHT blocker. Currently the most popular shampoo with the highest concentration of ketoconazole is a shampoo called Nizoral (pictured). Nizoral contains 2% ketoconazol. Ketoconazole is a highly toxic ingredient so you should only use Nizoral two or three times a week tops. There are several shampoos with lower concentrations of ketoconazole, which I’ve listed on my ketoconazxole shampoo page.

Nizoral a-d hair loss shampoo

My recommendation is to use a 2% ketoconazole shampoo twice a week and use a high quality hair loss shampoo for the rest of the week.

Green Tea

Organic green tea

A readily available, natural DHT blocker is green tea. Aside from other benefits, green tea contains epigallocatechin-3-Gallate (EGCG), a 5-alpha-reductase inhibitor. A study by the Harvard Medical School published in the Journal of Nutrition proved green tea reduces DHT levels.

Pumpkin seed oil

Pumpkin seed oil

Pumpkin seed oil has also been proven to inhibit the production of 5-alpha-reductase. Pumpkin seeds contain not one but two DHT blockers. The first is beta-sitosterol, a phytosterol, which is structurally like cholesterol. The other is a steroid, delta-7-sterine. A 2014 Chinese study evaluated the effect of a daily dose of 400mg of pumpkin seed oil on 38 men with AGA. A randomized equal number of men received a placebo. After 24 weeks, scientists discovered a 40% mean increase in hair count in the group receiving the pumpkin seed oil as compared to the placebo group.

It should be noted that a small percentage of men taking DHT blockers suffer from adverse side effects. These can include loss of sexual libido, depression and gynecomastia, the development of male breasts.

DHT blockers work, and there is ample scientific evidence to prove it. By inhibiting the destructive effects of the 5-alpha-reductase enzyme, hair loss can be slowed.

My Method for Removing DHT from the Scalp

DHT is the most significant cause of hair loss. What you’re about to read explains how to

  • safely remove DHT from your scalp;
  • unblock pores in your scalp;
  • and trigger your body to increase cell production, blood circulation and nutrient allocation in your scalp.

Ever noticed how bald and balding people almost always have shiny scalps?

Ever wondered what causes it?

That shininess is actually caused by a thick, dense, embedded layer of ‘sebum’ combined with dead skin cells and other materials, such as pollution and cosmetic products.

Sebum is the oil that secretes from your skins pores and helps condition your hair. However, it contains DHT.

There’s also a whole load of DHT just under your skin and flowing in your blood.

That’s the reason your hair is thinning.

It’s as simple as this: if you want to stop your hair loss you need to remove DHT from your scalp and block DHT in your body.

And if your scalp is shiny, your scalp is literally covered in a thick layer of hair killing sebum based plaque. If you do nothing else to help your hair do what you’re about to learn about.

Strip DHT Away From Your Scalp

The technique I’ve developed strips away the DHT containing sebum based plaque, leaving your scalp skin renewed, fresh and free to start growing hair again.

This technique unblocks the pores in the scalp, allowing hairs to grow freely.

And in my opinion, it’s vital that you do this if you want to regrow your hair.

You can use all the hair loss treatments in the world. But if you don’t do this, their effect will be minimal. You must perform this simple at home procedure if you want to stop your hair loss and regrow your hair.

DHT removed from the scalp

Remove DHT from the scalp

Not only does this technique strip away DHT from the scalp and unblock the pores, it also triggers your body to significantly increase blood flow to your hair follicles, which increases the amount of nutrients being sent to your hair.

The result is that your scalp starts to regrow new hair that was once being restricted by DHT.

This technique can be performed at home, on your own in around twenty minutes. If you have a very shiny scalp it will take a little longer — for some people it can take up to an hour to perform the technique. It’s well worth it though. Once your scalp is transformed you’ll notice your skin is fresh and ‘baby-like’ and is the ideal environment for hair growth. Your scalp will be flowing with blood, carrying nutrients to your hair.

Lupus Hair Loss: Why Does Lupus Cause Hair Loss and What Can You Do?

Lupus Hair Loss: What is it?

Lupus is an autoimmune disease in which our immune system fights against healthy tissues because the immune system confuses our bodies with foreign objects.

There are three types of lupus:

  • cutaneous,
  • systemic and
  • drug-induced lupus.

Cutaneous lupus affects the skin. Patients with this disease may have symptoms like severe fatigue, joint pain, joint swelling, headaches, a rash on the cheeks and nose, hair loss, anemia, blood-clotting problems and so on. Individual hair or hair clumps may fall out, or sometimes it just thins out. Hair loss in chronic cutaneous lupus is known as “scarring alopecia.”

Treatment for lupus hair loss patients involves suppressing the immune system, and alleviating the symptoms namely joint pain, headaches, with corticosteroids such as prednisone. In an 865-participant study by Lamore and colleagues, participants who received belimumab, a monoclonal antibody, had more improvements on lupus hair loss compared to the control group (1).

Why does lupus cause hair loss?

Lupus hair loss can be caused by the disease itself, especially the type of lupus called “chronic cutaneous lupus erythematosus.” This is the most common type of lupus. It may affect a patient’s scalp, leading to alopecia. In this sense, the patient’s immune system destroys hair follicles. In a study by Chung and colleagues, they found that from the biopsy specimens of 33 patients, participants’ scalps had a shortage of hair follicles at deep levels. Also, the size of hair follicles was smaller, and most of them were at the stages of catagen or telogen in which the hairs just last for a few days (2).

Since lupus patients usually take medications like corticosteroids and immunosuppressive drugs for controlling their condition, these medications can also cause a lot of side effects. One of them is hair loss (3).

What should you do?

Don’t wait to get treatment for your lupus condition. The sooner you are treated for lupus, the less hair loss you may suffer from. Go to see a dermatologist if you are aware of lupus hair loss.

Let your doctor know that you have hair loss while receiving lupus treatment, notably while taking corticosteroids or immunosuppressive medications. Your doctor can help adjust the dose of these meds and ensure that you get the best dose for both controlling the disease and reducing the side effects of the medications(4).

Avoid lupus flare-up as much as possible by managing your stress level, staying away from getting exposed to the sun which may be a trigger for the lupus flare-up, maintaining your healthy lifestyle and adhering to the treatment.

Some other things you can do to control your hair loss are:

References

  1. Lamore R, 3rd, Parmar S, Patel K, Hilas O. Belimumab (benlysta): a breakthrough therapy for systemic lupus erythematosus. P & T : a peer-reviewed journal for formulary management. 2012;37(4):212-26.
  2. Chung HJ, Goldberg LJ. Histologic features of chronic cutaneous lupus erythematosus of the scalp using horizontal sectioning: Emphasis on follicular findings. Journal of the American Academy of Dermatology. 2017;77(2):349-55.
  3. Qiao J, Sun Q, Jiang X, Fang H. Facial rash and alopecia in a patient with systemic lupus erythematosus. The Netherlands journal of medicine. 2017;75(3):125.
  4. Sinclair R. Diffuse hair loss. International journal of dermatology. 1999;38 Suppl 1:8-18.
  5. Herndon J. Systemic Lupus Erythematosus Healthline2016 [Available from: https://www.healthline.com/health/systemic-lupus-erythematosus#overview1.

10 Celebrities Who Have Had Hair Transplants

Have you noticed something strange about male celebrities in recent years? They seem to have the amazing ability to never lose their hair!

There’s a growing list of famous men who have had hair transplants, and why not? For stars of the stage and screen, looking good is their job, and they have to work at it. It’s all about the illusion of eternal youth and perfection, so many of them avoid publicity about their hair transplants. Still, for someone who’s constantly getting his picture taken it can be hard to avoid public scrutiny, and a growing number of high profile men are talking publicly about their choice.

Gordon Ramsay

Gordon Ramsay before and after

The British celebrity chef might certainly “blow your wig” with his amazing cooking skills, but he sure got a little bit of help keeping up with his trademark blonde hairdo. Ramsay was spotted leaving a surgical center in trendy Beverly Hills, with a surgical cap covering his head. The local media noticed that the chef had an unfortunate allergic reaction to the surgery, which gave away his secret!

John Travolta

John Travolta hair transplant before and after

The famous Hollywood star suddenly resurfaced showcasing a more lush hairline than ever before. The Pulp Fiction star might not sport that 70s hairdo, but he definitely gained some hair thickness in recent years!

That said we can’t be certain he’s had a hair transplant. In most pictures of him with hair he’s wearing a hair piece or some kind of semi-permanent hair system.

Nicolas Cage

Nicolas Cage hair transplant

The beloved Hollywood star managed to turn his receding hairline in somewhat of a personal trademark. Fans were shocked when they saw his hair transformation!

Matthew McConaughey

Matthew Mconnahay before and after hair transplant

Voted sexiest man alive in People Magazine in 2005, this hunky heartthrob is best known for going shirtless, showing off his buff body. In the interests of looking his best he has had his thinning hair filled in. Hey, he looked great either way but if a hunk like Matthew McConaughey is comfortable with hair replacement what have you got to lose?

Elton John

Elton John hair transplant

His hair started thinning back in the early 70’s. Always in front of the curve, Elton John was one of the first really famous people to get a hair transplant. He was such a super-star, and the change was so obvious, that he could not deny it. Hair transplant technology has come a long way since then, but you could say that Sir Elton was a hair transplant pioneer.

Mel Gibson

Mel Gibson before and after hair transplant

With his rugged, chiseled features, piercing blue eyes, and intense acting style, Mel Gibson had been a big box office draw for decades. He was People’s sexiest man alive in 1985, and made their 50 most beautiful people list many times. Although he has not gone public about his HT, in around 2006, his hairline, which had been receding, crept forward again, and the thinning hair on top became thick and lush. Inside sources have confirmed his HT, and said he’s very pleased with his new look.

Louis Walsh

Louis Waqlsh before and after hair loss

A judge on the British TV show The X Factor, Louis Walsh has spoken publicly about his hair transplant. He decided to have the surgery at the urging of his friend Simon Cowell. He has been quite open about the transplant, referring to it as “Maintenance,” and expressing his satisfaction with the procedure, which really does look quite natural. He has even gone as far as recommending his surgeon to friends.

Jason Gardiner

Jason Gardener before and after hair transplant

Acting as a kind of self-appointed Hair Transplant ambassador, the Dancing on Ice judge actually had his second hair transplant procedure broadcast on the internet as part of the Spencer Kobren series The Bald Truth. He enthusiastically removed his hat on TV, during Dancing on Ice. It was a long process for him, but the results are fantastic. He could not be more pleased. Jason Gardiner loves to spread the word to other men who are struggling with their own hair loss.

James Nesbitt

James Nesbitt hair transplant

This charming Irish actor has gone from curly-haired Adam in Cold Feet to a hard-boiled detective in Murphy’s Law. His hair loss had played out in the public eye, and he’s always been honest about his hair transplant, if a little bemused at how much public interest there is in it. He’s even made a promotional film for the Dublin clinic where he had the work done. He’s been quoted as saying that his hair restoration has changed his life, crediting it for a lift he’s experienced in his career post HT.

Wayne Rooney

Wayne Rooney before and after hair transplant

English footballer Wayne Rooney tweeted to his twitter followers confirming that he had a hair transplant.

Just to confirm to all my followers I have had a hair transplant. I was going bald at 25 why not. I’m delighted with the result. It’s still a bit bruised and swollen when it dies down u will be first to see it. Anyone recommend any good hair gel. Haha.

What a refreshing attitude. He is a young guy with plenty of money. Why not go for it? Well done Wayne!

Jason Donovan

Jason Donavon before and after hair transplant

Australian actor and singer, Jason Donovan, told Piers Morgan during an interview that he has had a hair transplant. He has said that he is really happy with the results. Donavon’s most recent gig has been appearing on the British TV show “Strictly Come Dancing.” He works in the public eye and says he just feels more comfortable with hair.

What an encouraging trend it is that men are willing to talk about their hair loss. After all, it’s not a personal failing to lose your hair, and there’s no shame in wanting to look your best. There’s nothing you can do about the genes you inherited, but there is something you can do about hair loss.

Women lose their hair too, not as often maybe, but it’s even more devastating for them when they do. Things like bleaching and hair extensions are very damaging and can cause patchy hair loss. However, it’s always been more socially acceptable for women to wear wigs and hairpieces, so it’s easier to cover up thinning hair. I don’t think anybody’s ever seen Dolly Parton’s real hair. Many stars like Beyonce, Christina Aguilera and Gwen Stefani wear wigs most of the time. Wigs are fun accessories, and they can protect the real hair from damage from all that styling, but if a lady needs hair augmentation, thanks to wigs, no one need ever know.

Do Hair Vitamins Work For Thinning Hair?

Hair vitamins

Male Pattern Baldness, and to a lesser extent Female Pattern Baldness, are common issues that can affect the lives of those who suffer from them. Many treatments are available, from medication to supplements. So do vitamins really work for reducing hair loss?

According to a recent study published in January 2017 named Diet and hair loss: effects of nutrient deficiency and supplement use focused on the question between nutrient deficiency and hair loss. The study revealed that there are several key vitamins and minerals that the human body might be deficient in, which may result in hair loss. If these vitamins and minerals are replenished in the body, the hair loss may stop and lost hair may regrow.

Iron Supplementation Stops Hair Loss

Iron deficiency (anemia) is a fairly common cause for hair loss in some groups of people, and it’s also a common nutrient deficiency. Certain groups of people are at higher risk of anemia, such as premenopausal women, as well as vegans who don’t consume enough iron-rich vegetables, which can explain why many vegetarians and vegans complain of hair thinning after going meat-free for a while.

According to a study published in 2013 entitled Iron Plays a Certain Role in Patterned Hair Loss, people who suffered from iron-deficiency induced hair loss were able to slow or stop their hair loss with iron supplementation, but little evidence exists when it comes to hair regrowth.

Zinc

Zinc is also an important vitamin connected with hair loss and regrowth. Zinc deficiency can cause many medical issues, with one being brittle hair, and hair loss. Aside from Iron, supplementation of Zinc in those with a deficiency has been shown to stop hair loss.

Fatty Acids

Being deficient in Fatty Acids, such as polyunsaturated essential fatty acids linoleic acid (omega-6 fatty acid) and alpha-linolenic acid, can also result in hair loss. Increasing dietary Omega 6’s or supplementing can benefit hair growth in the case of a deficiency. Borage Oil, for example, is a particularly rich source of Gamma-Lenolenic Acid (GLA), which has been shown in studies to be a potent natural DHT blocker.

Similar vitamin and nutrient deficiencies that can result in hair loss include Niacin, Vitamin A, Vitamin D, Selenium, Vitamin E, and Biotin. For many of these, it is unclear if even in the case of a deficiency, that supplementing will cause hair regrowth. For instance, the 2017 study states:

In terms of other amino acids and proteins, no clear conclusions may be drawn about the role of supplementation in hair loss. While trials of amino acid and protein supplements have been published, they are formulated with a variety of nutrients, and therefore it is unclear what role, if any, is played by amino acid and protein supplementation in the absence of known deficiency

In the case of a deficiency, taking specific vitamins or minerals can be effective in reducing or regrowing hair, depending on the nutrient. However, if one is not suffering from a deficiency, then there is no evidence that a vitamin supplement will be effective in regrowing hair.

In fact, due to the high amount of specific vitamins in certain branded hair regrowth vitamin pills, such as selenium, Vitamin A, and Vitamin E, one can actually worsen hair loss. Taking too much Iron supplementation as a way of combating hair loss can also lead to iron toxicity, which can be potentially dangerous. Always check with your doctor before considering nutrient supplementation for hair loss.

Conclusions

Research shows there are key nutrients that can promote hair growth. However there are some nutrients that can actually cause hair loss if too much is taken. Therefore the safest thing to do is to use a supplement designed to stop hair loss by providing the right balance of nutrients. If you’re not suffering from hair loss and you just want to make your hair grow faster consider using a supplement specifically designed to increase hair growth.

References and further reading

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678013/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836433/#R58

Hyaluronic acid for hair growth and hair loss prevention: does it work?

Hyaluronic acid is the natural acid that’s already present in our bodies. It shows up in the form of fluid present in the joints and human eyes. However, when this component is used in skincare products, it helps to prevent aging by locking moisture in the skin. Scientists have recently revealed that Hyaluronic acid doesn’t only play a part in the anti-aging products but it also helps in preventing the hair loss.

Due to its moisture locking trait, Hyaluronic acid also plays a part in controlling the hair loss. It controls the dryness of the scalp and thinning of the hair. The famous dermatologist Dr. Paradi Mimirani has claimed that HA works as a “fertilizer for the hair”. Recent research has concluded that HA not only provides a boost to hair growth, it also increases the diameter of individual hairs.

A study was conducted by Michelle R., Yagoda MD and Eugene H. Gans PhD in which participants were provided with a 20gm oral dose of hyaluronic acid daily and other supportive components over the duration of 60 weeks. The results showed significant improvement in hair dullness and hair dryness along with nail cracking, nail softness and nail peeling.

Doctors strongly recommend children suffering from Progeria to use HA for the treatment of their hair loss and premature aging. HA can be used by every anyone to control the signs of aging and treat the hair loss as it is suitable for every body type. Hyaluronic acid can be consumed in various forms such as supplements, injectable fillers, topical products and hair products.

Highest rated hyaluronic acid products on Amazon

  • Hyaluronic acid serum
  • Hyaluronic acid supplement
  • Pure hyaluronic acid serum

Best Vitamins for Hair Growth: A Complete Guide

If you live in America, Canada, the UK, Australia or other relatively rich country, it’s unlikely that you suffer from any severe nutrient deficiencies that could negatively affect your health.

However, studies have shown that boosting your intake of certain vitamins, minerals, amino acids and herbs can increase the rate of hair growth and even reduce hair loss.

The important thing is to understand which vitamins will have a hair growth boosting effect for you. The simplest solution is to take a supplement that’s designed to increase hair growth. All of the below supplements have been designed for that purpose.

Key nutrients for hair growth:

Top 10 best supplements for hair growth

  • Solgar Skin Hair and Nails Supplement

    Solgar Skin, Nails and Hair Tablets

    Around $20 for 120 tablets

    • Provides all necessary nutrients for healthy hair and skin
    • Sugar free, salt free and suitable for vegetarians

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Natrol Biotin Maximum Strength hair vitamins

    Natrol Biotin

    Around $10 for 100 tablets

    • Contains biotin, which is extremely important for hair health and also a great energy booster
    • Promotes cell growth and speeds up metabolism

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Hair Vit Hair Vitamins for strong hair

    HealthAid Hair-vit

    Around $45 for 90 capsules

    • Healthy, strong hair and nails
    • Thick, healthy looking hair for both men and women
    • Cysteine has been shown in several studies to increase hair growth

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Vitabiotics Wellman HAIRFOLLIC MAN Hair Growth Tablets

    Vitabiotics Wellman HAIRFOLLIC MAN Hair Growth Tablets

    Around £35 for 60 tablets

    • Maintains hair thickness
    • Effective hair and scalp conditioning
    • Suitable for vegetarians

    Ingredients

    Buy online (UK)

  • Nordic Hair Volume vitamins

    New Nordic Hair Volume

    Around $35 for 30 tablets

    • Natural apple hair growth factor (procyanidin B2)
    • Boosts hair growth and volume

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Neocell Collagen and Vitamin C for hair growth

    NeoCell Super Collagen and Vitamin C Tablets

    Around $25 for 250 tablets

    • Colagen builds bone matrix
    • Firm, hydrated skin
    • Thickens hair

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Vitamins for long hair growth

    Long Hair Growth Vitamins – Intense Grow (3 pack)

    Around $45 for 180 capsules

    • Longer, thicker hair
    • Hair volume and softness

    Ingredients

    Buy online (USA)

  • Hair Formula 37 best hair growth vitamins

    Hair Formula 37

    Around $25 for 60 capsules

    • Longer, healthy hair
    • Excellent for dry, brittle hair

    Ingredients

    Buy online (USA)

  • Fast Grow African American Hair Vitamins for black people

    Fast Grow African American Hair Vitamins

    Around $60 for 270 capsules

    • Fast hair growth
    • Long hair full of volume

    Ingredients

    Buy online (USA)

  • Vibrance Vitamins for Hair Growth

    Vibrance Healthy Hair Vitamins

    Around $45 for 60 capsules

    • Faster, healthier hair growth
    • Fights against thinning hairli>

    Ingredients

    Buy online (USA)

Top 10 foods containing hair growth vitamins

Supplements are a good way to increase your intake of vitamins that support hair growth but they are not a replacement for good diet. If you want healthy hair that grows fast and doesn’t fall out you try to include these foods in your diet regularly.

Please note: don’t consume any of these foods in excess. It won’t necessarily make your hair grow faster and consuming excessive amounts of foods containing high concentrations of certain nutrients can have negative effects on your health.

  • Salmon

    Salmon

    Key nutrients

    • Biotin
    • Phosphorus
    • Omega-3 fatty acids
    • Amino acids
    • Vitamins A, B, B6, D, E

    Key facts per 100g

    • Energy: 208 kcal
    • Sugar: 0g
    • Fat: 13g

  • Walnuts

    Walnuts

    Key nutrients

    • Biotin
    • Magnesium
    • Copper
    • Vitamin E
    • Omega-3 fatty acids

    Key facts per 100g

    • Energy:654 kcal
    • Sugar: 2.6g
    • Fat:65g

  • Mushroom

    Mushrooms

    Key nutrients

    • Selenium
    • Potassium
    • Riboflavin
    • Niacin
    • Vitamin D

    Key facts per 100g

    • Energy: 38 kcal
    • Sugar: 1.2g
    • Fat: 0.5g

  • Swiss chard

    Swiss Chard

    Key nutrients

    • Vitamins B6 and B12
    • Biotin
    • Vitamin C
    • Vitamin D
    • Calcium
    • Iron
    • Magnesium

    Key facts per 100g

    • Energy: 19 kcal
    • Sugar: 1.1 g
    • Fat: 0.2g

  • Carrots

    Carrots

    Key nutrients

    • Vitamin C
    • Biotin
    • Vitamins B6 and B12
    • Vitamin D
    • Vitamin A
    • Beta carotene
    • Calcium
    • Iron
    • Magnesium

    Key facts per 100g

    • Energy: 41 kcal
    • Sugar: 4.7g
    • Fat: 0.2g

  • Bananas

    Bananas

    Key nutrients

    • Vitamin A
    • Vitamin C
    • Vitamins B6 and B12
    • Calcium
    • Iron
    • Magnesium

    Key facts per 100g

    • Energy: 89 kcal
    • Sugar: 12g
    • Fat: 0.3g

  • Blueberries

    Blueberries

    Key nutrients

    • Biotin
    • Vitamin A
    • Vitamin C
    • Vitamin B6
    • Iron
    • Magnesium

    Key facts per 100g

    • Energy: 57 kcal
    • Sugar: 1.8g
    • Fat: 0.3g

  • Lentils

    Lentils

    Key nutrients

    • Biotin
    • Iron
    • Vitamin B6
    • Magnesium
    • Calcium

    Key facts per 100g

    • Energy: 116 kcal
    • Sugar: 1.8g
    • Fat: 0.4g

  • Greek yogurt

    Greek yogurt

    Key nutrients

    • Protein – 20%
    • Vitamin B12
    • Vitamin B6
    • Calcium
    • Magnesium

    Key facts per 100g

    • Energy: 59 kcal
    • Sugar: 3.2g
    • Fat: 0.4g

  • Organic stone ground bread

    Stone ground whole grains

    Key nutrients

    • Magnesium
    • Vitamin B7 (suppresses the formation of gray hair)
    • Vitamin B6
    • Iron
    • Calcium

    Key facts per 100g

    • Energy: 247 kcal
    • Sugar: 6g
    • Fat: 3.4g

  • Conclusion

    All of these vitamins work together as a team, which is why a balanced, varied diet is very important. Vitamin C improves blood circulation to the scalp, making it possible for the other vitamins to nourish the hair follicle. After all, we are what we eat and therefore the look and feel of your hair will improve significantly!

    Are you missing something?

    Its likely that diet is actually one of the less important factors in your fight for healthy hair. In fact, stress and hormonal balance may be more important factors to consider. All of these things are linked though and since healthy diet is probably one of the easiest things to control it’s a good place to start.

    A hair growth supplements strategy

    Start by avoiding processed foods, too much meat, white flour and refined sugar. Try to include healthy quantities of essential fatty acids and B vitamins in your diet.

    Once your diet is in good order try to improve your stress levels by taking time every day to relax in a quiet place without TV, radio or internet to distract you and cause stress.

    Next — Supplementation

    There are some products that actually work to prevent further hair loss, and some can even cause regrowth. There are other products available that are so far removed from real science (and even common sense) that you will want to steer clear of them. They will do nothing but line the pockets of their purveyors with your cash, and give you a placebo effect.

    The placebo effect has a long, glorious history in human culture. The entire pseudoscience of homeopathy is based on the placebo effect. The good part about the placebo effect is that when you think something should work, your expectation triggers your body’s own repair mechanism. Years of research have shown that in test subjects given a placebo drug (sugar pill or capsule with corn starch) that their reaction can sometimes be greater than if provided with a “real” drug, provided the doctor is friendly and supportive and tells them it will work.

    Herbal Supplements & Nutraceuticals

    None of these things are regulated by any medical authority other than to say they cannot make medical claims about them. They’re treated as food/dietary supplements. Consequently, people selling them often imply incredible properties, referring to customer testimony as evidence. Note that they are all followed by statements such as “This product is not intended to diagnose, treat, or cure any medical conditions. Always consult with your physician” or something to that effect.

    Sadly, sellers often “buy” custom-tailored reviews of their products via the many online work sites. They will usually say precisely what you are hoping to read. It is impossible to know if the statements were written by real customers, or an employee. That is why you need to know the real science behind a product.

    Poor nutrition, radiation, or massive assaults to the body’s natural chemistry (such as chemotherapy, even when essential), can most certainly cause hair loss. Biotin, polysaccharides, and even certain marine-derived proteins have been shown to have supportive effects for hair quality and maintenance. Beyond that, herbal supplements are mostly wishful thinking unless you have a true deficiency.

    Saw palmetto

    Saw Palmetto, for example, was once touted as a cure for BPH (benign prostatic hyperplasia) and prostate cancer, and was supported by meta-analysis. Actual follow-up studies found it no more effective than a placebo. People who had already invested in harvesting the plant looked for other uses and may have found a mild potential to interfere with 5-AR (5-alpha-reductase).

    5-AR is an enzyme that converts normal testosterone into dihydrotestosterone (DHT), a more powerful form, which is responsible for hair growth on the body from the beard downwards.

    It is unnecessary for scalp hair growth, and actually shuts down the hair follicles if it gets there, causing hair loss. If you are particularly hairy over your body, your chances of scalp hair loss may be significantly higher because of the presence of DHT in above average amounts.

    As an oil-based extract applied topically (on the skin), saw palmetto cannot harm you, and may provide a benefit. Do not take this orally, as it can lead to stomach ulcers, cramps, and bleeding; bloody stools and pain are common symptoms.

    Curcumin

    Curcumin has potential drawbacks because in inflammation studies on arthritis with doses of 1200mg or more per day, it caused slight hair loss, as shown in these six studies. (NIH.1) (NIH.2) (NIH.3) (NIH.4) (NIH.5) (NIH.6) In lower doses it may be beneficial, as an anti-inflammatory, but there is no clinical evidence of benefits for your hair.

    Black pepper oil

    Black Pepper Oil is said to activate the Curcumin mentioned above. If you’re going to take one, you should take the other, since they are said to be interdependent, despite the lack of evidence for either one being useful.

    Capsaicin

    Capsaicin is the “heat” of most hot peppers, and seems to be related to the up-regulation of Insulin-like Growth Factor I (IGF-I). This factor is responsible for stimulating hair follicles to grow as well as prolonging the period of time that they grow, and shortening the “rest period” in between. This study (NIH.7) shows the importance of IGF-I. Another study showed that while the hair length increased significantly during the sustained growth period, 20 × 1cm strands, from both before and after, did not vary in mass, so the hair was growing faster but not thicker.

    Biotin

    Vitamin B7 (biotin) supports all sorts of bodily functions, and a lack of it, either through poor diet or a genetic problem that interferes with the biotin mechanism, can cause a number of problems. One of the main ones is thinning hair. We have bacteria in our guts that make biotin for us, and it is readily available in a normal diet so adding it to a product seems more for show than actual function.

    Vitamin D3

    Vitamin D3 is also important to hair follicle health. (NIH.8) Vitamin D was found to be so important that most dairy farmers or milk producers add vitamin D (and vitamin A) to most milk products. People who don’t consume much milk (or dairy products) in their diet might be deficient in both vitamin A and vitamin D.

    Vitamin E

    Vitamin E, or any vitamin for that matter, is not going to stop genetic/inherited hair loss, or suddenly cause hair to grow where the follicles are long dead and gone. Some vitamins are toxic in large doses, and most just give you really expensive urine.

    Vitamin E can, however, reduce oxidative stress as shown is this study. (NIH.9) It can “save” hair that is on the verge of failing, but a deficiency is nearly impossible to achieve because it is so plentiful in a normal diet. Examples of good sources: Oils of corn, soybean, wheat germ, sunflower and safflower, and readily in foods such as margarine and salad dressings.

    Hyaluronic acid

    Hyaluronic Acid has a strong effect on the moisture content of skin. As we age, the skin of the scalp has less fatty tissue and becomes thinner and drier. This is made worse by exposure to the Sun, and by cigarette smoking. Consequently, it’s much less capable of supporting hair follicles. Hyaluronic Acid is used frequently as a dermal filler (to get rid of wrinkles), but in one notable case, when only 6.5ml was used on an accident victim to fix his scalp, the resultant hair loss required treatment with minoxidil to get the hair to regrow. It seems to be safe if ingested, or applied topically, but should never be injected in the scalp.

    Minoxidil has its own set of problems. Miracle discovery for many, the truth is that it is only effective in about 20-40% of patients in formulations between 2-5%.
    This is because it requires the presence of an enzyme called sulfotransferase that not everybody possesses in amounts sufficient to activate the minoxidil.
    Sixty percent or more will get disappointing results. When it does work, you must continue to use it to maintain the effect. Stubborn cases may work when it is fortified with 0.1% finasteride (which has been proven to interfere with 5-AR), but that can result in gynecomastia (growing breasts), decreased sexual desire, and even sexual dysfunction. That seems like a bad trade-off.

    Marine glycosaminoglycans

    Marine glycosaminoglycans have been demonstrated to be effective for women’s hair restoration when applied topically, especially with sun-damaged skin. Glycosaminoglycans include the rescue medication for strokes and blood clots called Heparin.

    Ginkgo Biloba

    Ginkgo Biloba, in a Japanese study (NIH.10) from 1993, concluded that GB extract promotes hair regrowth and could be used as a hair tonic.

    Other nutrients for hair growth

    Lysine, Zinc and Magnesium have clear effects on hair growth which are well-established. Tests include causing a deliberate deficiency in a lab animal to ascertain the effects. When these substances, individually or collectively, are in short supply there are numerous consequences, not the least of which is a lowered quality, strength, or even the loss of hair. But, as one study (NIH.11) points out, “Excessive intakes of nutritional supplements may actually cause hair loss and are not recommended in the absence of a proven deficiency”, so talk to your health care provider first and get tested or none of these will do much good.

    Transplantation

    Hair restoration surgery has advanced, however the original technique for harvesting small plugs of hair surgically often damages them so they are not viable. The current standard requires taking a strip of scalp and then surgically sectioning useable bits. This leaves a scar that will require a particular hair style to keep covered. It’s much worse with a bad, inexperienced, or cut-rate surgeon (see photo). It is tender for two to four weeks, when you lean your head forward.

    A new (often robotic) technique called FUE (Follicular Unit Extraction), grabs small units of hair, only 1mm in size, each consisting of about four strands. It only leaves a tiny white circle scar because a square inch of skin has about 2,000 hair follicles (44 × 44). It keeps the natural fat and tissue so it almost always survives when put in place. It’s taken from a much broader area, requires no sutures, heals very quickly, and leaves no scar.

    The Takeaway

    In our society, faced with losing our hair, it can be a pretty traumatic experience. This is notwithstanding the fact that Sir Patrick Stewart, Bryan Cranston, and numerous other high profile public figures have done a lot to destigmatize baldness. Many people have actually embraced it, shaving their heads clean despite having a full head of natural hair.

    Nevertheless, if you’re feeling uncomfortable about your hair status, talk to your doctor about all the real science answers. It’s possible that it could be a real pathology or disease that needs to be treated, like a thyroid condition; if not, the doctor can outline some options that we already know have a good chance of success.
    In the United States, in the 1800s, “medicine shows” moved from town to town selling elixirs and tonics to cure everything, from snake bites, to cancer, to gunshot wounds. Now we have the internet, and people there are perfectly happy to take your money if you offer it to them. We all want to be healthy and attractive, but the odds are that you don’t need “Snake Oil” or “Mother Lester’s World Famous Tonic” to make that happen. Try these “cures” if you have a few Euros or Pounds that you are not overly fond of—but don’t expect miracles.

    References

    1. NIH.1. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19678780
    2. NIH.2. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24853120
    3. NIH.3. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964021/
    4. NIH.4. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244558/
    5. NIH.5. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25308211
    6. NIH.6. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22407780
    7. NIH.7. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283847/
    8. NIH.8. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876678/
    9. NIH.9. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283847/
    10. NIH.10. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8254481
    11. NIH.11. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/12190640

Peppermint oil and hair loss

Peppermint oil

Peppermint oil comes from peppermint, a native plant in Europe and is frequently used for various therapeutic applications like oils, shampoos and lotions. It has been used to relieve flatulence and as a gastric stimulant. Peppermint oil comes from a family of liquids known as essential oils, which basically means liquids containing volatile aroma compounds from plants. They contain the ‘essence’ of the plant’s fragrance and are frequently used in aromatherapy and perfume production.

Anti-inflammation: a key to hair loss prevention

Peppermint is usually known for its main ingredient, menthol, which has been proven to have a distinct cooling and refreshing sensation which has been used as a treatment to counter itchiness in humans, whether it is ingested or applied(Bromma et al., 1995) as well as an analgesic (pain reliever)(Galeotti et al., 2002). As an ingredient in treating hair loss, peppermint is extremely useful in soothing the scalp as an anti-inflammation substance, treating inflamed hair follicles which can prevent optimal hair growth. A study in 2014 (Oh, Park & Kim, 2014) recently compared the effectiveness of peppermint treatment with 4 other treatment options (including minoxidil, the recommended treatment for hair loss) and found that peppermint exhibited significant increase in dermal thickness, follicle number, and follicle depth compared with other treatments when done on mice. This has confirmed numerous anecdotal evidence of the usefulness of peppermint oil in combating hair loss.

Besides directly impacting the scalp, peppermint oil also helps stimulate hair growth by increasing blood circulation around the scalp and cleaning the area around the scalp; this helps prevent scalp buildup (sweat, sebum, dead skin etc) which can lead to irritation and inflammation. It also has antimicrobial and antifungal properties which can help prevent the growth of fungus and bacteria on the scalp, which are common causes of dandruff.

However, despite the powerful therapeutic properties of peppermint oil, too much of it at one shot can be harmful to our naked skin. When using peppermint oil, it is highly advisable to use it in conjunction with another carrier oil such as jojoba oil or coconut oil, followed by massaging it gently upon the scalp to ensure full absorption into the skin. It is also recommended that you do a small skin patch test beforehand to ensure that your skin does not react adversely to menthol. In conclusion, peppermint oil is a highly potent compound capable of soothing and healing the scalp when applied, however too concentrated a dose will likely result in damaging the skin instead of healing it.

Use with carrier oil such as jojoba oil or coconut oil. Important to use proper dilution when applying as it might hurt the scalp if applied directly

References

  1. Bromma, B., Scharein, E., Darsow, U. & Ring, J. (1995) Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neuroscience Letters. 187 (3), 157-160.
  2. Galeotti, N., Mannelli, L. D. C., Mazzanti, G., Bartolini, A. & Ghelardini, C. (2002) Menthol: a natural analgesic compound. Neuroscience Letters. 322 (3), 145-148.
  3. Oh, J. Y., Park, M. A. & Kim, Y. C. (2014) Peppermint Oil Promotes Hair Growth without Toxic Signs. Toxicological Research. 30 (4), 297-304.

What is the Best Hair Loss Supplement (Reviewed)

There are hundreds of hair loss supplements. Choosing one is a gamble: it’s hard to know if it will be the answer you’ve been looking for or have no effect on your hair.

I’ve researched over a hundred products and finally arrived at the list you see below — these are what I believe to be the best supplements for reducing hair loss and encouraging hair growth. But make sure you read to the bottom, where you’ll find my guide to how to maximizing hair growth using these supplements.

  • Nutrafol Men Advanced Thinning Hair Loss Supplement

    Nutrafol Men Advanced Thinning Hair Loss Supplement

    $88 for 120 Capsules

    Wow, what can I say? This is the best hair loss supplement I’ve ever seen. I’ve been studying the hair growth effects of thousands of different nutrients and this supplement contains almost all the key nutrients that promote hair growth and prevent hair loss. It has the key amino acids, DHT blockers, inflammation reducers, key vitamins and minerals and several other beneficial nutrients. This supplement tops the list but is very expensive. So it’s worth checking out the others on this page (which are also very good) if you don’t want to spend this much.

    • Contains saw palmetto, which has been shown in several small studies to block the enzyme 5 alpha reductase, which effectively reduces DHT levels
    • Curcumin is highly benefhaicial for reducing inflammation, which is key to preventing progression of male pattern baldness
    • Contains vitamin E, which is beneficial for hair and skin health
    • Contains hyaluronic acid, which may improve skin health
    • Contains cysteine, lysine and methionine — these are three of the 5 key amino acids identified as being effective at increasing hair growth
    • Contain silica, which has been shown to improve health of skin and connective tissue and has been identified as a key nutrient for hair growth
    • Contain resveratrol, a powerful natural antioxidant which has been shown to slow down aging due to antioxidant action on cells
    • Contains Bioperine, a patented form of black pepper, which has been shown in studies to improve nutrient absorption
    • Contains capsaicin (the ingredient which gives chilli peppers their heat), which has been shown to reduce male pattern baldness by increasing dermal IGF-1 — the growth factor required that seems to play an important role in hair growth
    • Contains biotin, which is used by the body to transform amino acids into proteins like keratin, among other functions. It’s therefore vital for healthy hair and skin
    • Contains vitamin D3 is required to regulate calcium levels and plays other important roles in hair growth. Studies show vitamin D deficiency may lead to hair loss
    • Contains fish collagen. This is interesting because it’s similar to shark cartilage used in Nourkrin hair supplements. It’s what Nourkrin say makes their supplements work. However I’ve seen no research to suggest this does work. Still it’s worth a mention because there must be some reason fish/shark meat is used in hair supplements. It may be beneficial due to the amino acid content?

    Ingredients

    Buy online (USA)

  • Nutrafol best hair loss supplement for women

    Nutrafol Women Advanced Thinning Hair Loss Supplement

    $88 for 120 Capsules

    This is the women’s version of the Nutrafol supplement shown above. It has the same ingredients but is geared towards women.

    • Review coming soon

    Ingredients

    Buy online (USA)

  • Ultrax Labs Hair Rush hair loss supplememt

    Ultrax Labs Hair Rush

    Around $60 for 30 tablets

    This hair loss supplement is by the brand that makes one of the world’s best hair loss shampoos, which is a good sign.

    Ingredients

    Buy online (USA)

  • Wick and Strom Hair Loss Supplement

    Wick & Strom DHT Blocker Hair Loss Supplement

    Around $40 for 60 tablets

    Nanogen’s supplement contains an excellent range of ingredients and has many benefits for your circulatory system, DHT levels and hair growth. It’s a well rounded product tackling hair loss from several angles.

    Ingredients

    Buy online (USA)

  • Nanogen hair loss supplement for men

    Nanogen Hair Nutrition Supplement Men 40 +

    Around $40 for 60 tablets

    Nanogen’s supplement contains an excellent range of ingredients and has many benefits for your circulatory system, DHT levels and hair growth. It’s a well rounded product tackling hair loss from several angles.

    • Vitamin C is key to circulatory health — which in turn is key to nutrient supply to the hair via blood vessels
    • Saw palmetto is one of the most powerful natural DHT inhibitors — DHT is the primary cause of male pattern baldness
    • Methionine and cysteine are two of the main amino acids found in hair keratin
    • Horsetail is a good natural source of silica
    • Ginseng promotes blood circulation — particularly in the extremities — and is therefore thought to boost memory and may help increase blood supply to the hair
    • Resveratrol is a powerful antioxidant
    • Niacin boosts blood flow to the extremities and may be key in delivering nutrients to the hair
    • Arginine is a component of hair keratin and is also known to improve blood circulation
    • Studies show taurine boosts hair growth and is thought to provoke the body to use cysteine for hair — based on a L’Oreal study conducted for the production of their Hair Mass product
    • Zinc, biotin and selenium are all beneficial in for hair growth

    Ingredients

    Buy online (USA)

  • RegenePure hair loss supplement

    RegenPure Maximum Strength Hair Loss Supplement

    Around $40 for 90 tablets

    This is a pretty awesome new supplement from RegenePure. It contains just about everything you want in a hair loss supplement — biotin for converting amino acids into hair keratin, the key amino acids for hair growth, a great mix of natural DHT blockers and key hair growth supporting minerals.

    • Biotin is the top ingredient — biotin is a crucial B vitamin for improving hair health
    • Contains a a range of B vitamins, which support hair and skin health
    • Contain iron, which supports healthy blood and is widely thought to improve hair health — particularly in women
    • Contains saw palmetto, which is one of the best natural DHT blockers
    • Contains an excellent range of amino acids — amino acids are the building blocks of hair
    • Contains Fo-Ti, which is widely thought to reduce hair loss
    • Contains horsetail — a natural source of silica — a key building block of hair
    • Contains zinc, a mineral that supports hair growth
    • Contains pygeum and nettle extract — which are thought to be two of the best natural DHT blockers
    • Contains MSM — a natural source of sulphur. Sulphur is a key component of hair keratin and is required for hair growth

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Corvinex hair loss supplement

    Corvinex Hair Vitamin Supplement

    Around $25 for 60 tablets

    Corvinex contains an excellent all round range of nutrients that benefit hair growth, including a large quantity of amino acids (which differentiates this supplement from others). It contains blood circulation improvers, DHT inhibitors and vitamins for hair growth.

    • Niacin is the top ingredient, which should help effectively deliver nutrients to the hair
    • Contains a good array of B vitamins to support healthy hair and skin
    • Biotin is high in the list, which is a crucial B vitamin for improving hair health
    • Contains iodine, which helps support healthy thyroid function
    • Pumpkin seed and saw palmetto are good natural DHT blockers
    • Inositol helps support healthy liver function
    • Gingseng helps support good blood circulation in the extremities (essential for nutrient delivery to the hair)
    • Contains an excellent range of amino acids, which are the building blocks of hair keratin
    • Contains pantothenic acid, which helps increase co-enzyme A levels in the liver, which, among other things, helps reduce skin sebum levels
    • Muira Puama may help improve blood circulation
    • Inositol helps reduce symptoms of PCOS and anxiety

    Ingredients

    Buy online (USA)

  • Hair Covet hair loss supplement

    Hair Covet Hair Growth Supplement by Lipogaine

    Around $30 for 90 tablets

    Hair Covet is a hair loss supplement made by Lipogaine who produce one of the world’s best topical hair loss treatments. Lipogaine have concentrated on powerful herbal extracts in their supplement and less so on supporting vitamins such as Biotin and vitamin C. Therfore if you use this supplement, check out my lists of foods highest in B vitamins and vegetables high in vitamin C.

    • High in saw palmetto, a fairly powerful natural DHT blocks
    • Extra beta sitosterol, the extract from saw palmetto that blocks DHT
    • He shou wu is a fairly potent herb used for many years in Chinese medicine to prevent male pattern baldness
    • Ginkgo biloba helps improve blood circulation in the blood vessels in the scalp that deliver nutrients to the hair
    • Green tea and grape extract may supply a good dose of antioxidants, which scavenge free radicals, helping to keep cells healthy
    • Stinging nettle is thought to help block DHT production by inhibiting 5 Alpha Reductase
    • MSM provides natural sulphur that may help increase hair keratin and increase the hairs growth phase
    • Nettle may help reduce DHT

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Toji Pure Density Hair Regrowth Supplement

    Toji Pure Density Hair Regrowth Supplement

    Around $25 for 60 tablets

    Toji contains a huge array of beneficial ingredients covering healthy hair growth support, DHT inhibition, blood circulation improvement, antioxidants, amino acids and several less common supporting ingredients.

    • Contains a good array of B vitamins and antioxidant vitamins for supporting healthy hair and skin
    • Contains iodine from kelp to help support healthy thyroid function
    • Contains saw palmetto to naturally reduce 5 alpha reductase and therefore prevent the conversion of testosterone into the hair killing DHT
    • Contains Cysteine — the largest constituent amino acid in hair keratin
    • Contain ginkgo biloba, which may help carry nutrients to the hair by improving blood flow to the skin
    • Contains grape seed extract, which may be a good source of antioxidants (depending on which part of the grape is used)
    • Inositol helps reduce symptoms of PCOS and anxiety
    • Contains stinging nettle, which may help reduce DHT

    Ingredients

    Buy online (USA)

  • Reservage Organic Keratin Booster and DHT Blocker

    Reservage Organic Keratin Booster and DHT Blocker Supplement

    Around $30 for 90 tablets

    The Reservage product has quite a different angle on its hair loss supplement — but a good one. It contains high quality, organic ingredients including high levels of biotin and red grape, which are rich in resveratrol. It also contains “soluble keratin”, which the producer claims increases keratin in the hair, helping to grow more hair. If two capsules are taken per day this supplement contains just about the perfect amount of saw palmetto, according to my research on natural 5-alpha-reductase inhibition. An interesting product.

    • High volume of biotin — a key ingredient for supporting healthy hair growth
    • Contains the innovative “Solubalized keratin”, which may help boost hair growth
    • Contains resveratrol, which is high in antioxidants
    • Contains saw palmetto, which at two capsules per day is about the right amount to block DHT (320mg)
    • Organic produce contains higher levels of nutrients

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Hairaneew biotin hair growth supplement

    HairANew Biotin Hair Growth Vitamins

    Around $60 for 60 tablets

    The HairAnew supplement is almost entirely focused on nourishing the hair with vitamins and minerals. It has no DHT inhibiting ingredients but it does contain kelp for healthy thyroid function in addition to the hair nutrition vitamins and minerals.

    • As with the NuHair product, vitamin C is a prominent feature of HairANew, which is highly beneficial for your circulatory health — which in turn is key for healthy supply of nutrients to your hair and will also help with skin health and other health areas.
    • A reasonably high dose of niacin is used in this supplement, which is excellent for aiding the delivery of nutrients to the hair — niacin cause the body to flush blood to the skin.
    • The HairANew supplement contains a large portion of biotin, which is probably the most important supportive nutrient for hair growth
    • Kelp is a good natural source of iodine, which supports thyroid gland health. An overactive thyroid gland is known to cause hair loss in some people.
    • Inositol supports liver health, which is important for healthy hair
    • Contains silica, which helps build keratin for hair growth

    Ingredients

    Buy online (USA)

  • Hairomega 3 in 1 high strength all round hair loss supplement

    HairOmega 3-in-1 Hair Loss Supplement

    Around $20 for 90 tablets

    The HairOmega supplement has a well rounded approach to hair loss prevention — it inhibits DHT, supports healthy hair growth and supplies a number of key supporting nutrients.

    • Contains saw palmetto, pumpkin and green tea, which naturally inhibit DHT to help prevent male pattern baldness
    • Contains cysteine, which is the predominent amino acid in hair keratin
    • Contains biotin and other B vitamins, which support healthy hair and skin
    • Contains iodine, which helps regulate healthy thyroid function — an over-active thyroid is known to cause hair loss
    • Contains ginkgo biloba, which supports healthy blood circulation in the extremities — key for delivering nutrients to the hair
    • Inositol supports healthy liver function
    • Green tea and grape seed extract are good sources of antioxidants

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Advecia Hair Loss Supplement

    Advecia Hair Loss Supplement

    Around $30 for 90 tablets

    Advecia is a good hair loss supplement for men because it contains natural DHT blockers. In fact the supplement is almost entirely DHT blockers and antioxidants.

    • Contains saw palmetto extract, which helps reduce blood DHT levels
    • Contains green tea extract, which may also reduce blood DHT levels and provides antioxidants
    • Contains arginine, which helps your body produce citruline, which helps improve blood circulation
    • Contains beta sitosterol, which helps reduce blood DHT levels
    • Contains lysine, which studies show increases hair growth speed
    • Contains grape seed extract, which is a good source of antioxidants, providing the grapes are not heated to high temperatures during processing

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • TRX2 powerful hair growth supplement

    TRX2 Molecular Hair Supplement

    Around $75 for 90 tablets

    TRX2 is perhaps the most innovative hair loss supplement available and it uses a powerful cocktail of natural substances to produce what might be considered a more profound impact on hair than other hair loss supplements. However, it contains much less of the supporting nutrients that other supplements contain — for example it doesn’t reduce DHT levels.

    • TRX2 is the only hair loss supplement known to use the innovative method of combining L-Carnitine, niacin and potassium to improve the function of the potassium ion channels in the hair.
    • The niacin helps effectively deliver the ingredients to the hair
    • Zinc, magnesium, biotin and selenium are all key supporting nutrients required for healthy hair growth

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Harvey and Coco Root Rehab hair growth supplement

    Harvey and Coco Root Rehab Hair Loss supplement

    Around £50 for 90 capsules

    This supplement contains the key amino acids that build hair keratin and promote hair growth. It also contains biotin, which supports hair growth by helping the body convert amino acids into hair keratin.

    • Vitamin C is key to circulatory health — which in turn is key to nutrient supply to the hair via blood vessels
    • Methionine, cysteine and lysine are three of the main amino acids found in hair keratin and are strongly considered to promote hair growth
    • Horsetail is a good natural source of silica
    • Zinc and biotin are both beneficial in for hair growth
    • Acerola cherry is a good natural source of antioxidants

    Ingredients

    Buy online (UK)

  • Bosley hair supplement for women

    Bosley Hair Supplement for Women

    Around $16 for 60 tablets

    Ingredients

    Buy online (UK)

  • Nourish hair growth support vitamins

    Nourish hair growth support vitamins

    Around $25 for 60 tablets

    • Review coming soon

    Ingredients

    Buy online (USA)

  • Great hair formula

    Great hair formula

    Around $20 for 60 tablets

    • Review coming soon

    Ingredients

    Buy online (USA)

  • HairXcel hair loss supplement

    HairXcel Hair Loss Supplement

    Around $30 for 60 tablets

    • Review coming soon

    Ingredients

    Buy online (USA)

  • Vie Naturelle Pro T Select Hair Growth supplement

    Vie Naturelle Pro T Select Hair Growth supplement

    Around $20 for 30 tablets

    • Review coming soon

    Ingredients

    Buy online (USA)

  • Zenwise hair growth vitamins + DHT blocker

    Zenwise Health Hair Growth Vitamins + DHT Blockers

    Around $20 for 30 tablets

    • Review coming soon

    Ingredients

    Buy online (USA)

What's the best supplement for hair loss?

Questions, Recommendations, Suggestions?

If you have a question, have seen an error or you know of a supplement you think should be listed here, please post a reply using the link below.

Ingredients to look for in a good hair loss supplement

There is strong evidence showing that some ingredients reduce hair loss and even increase hair growth. Below are ingredients that have been studied and shown to cause observable improvements in hair loss. Therefore by using supplements containing the below ingredients you can be more certain the product will work.

Saw palmetto

Several studies have shown that saw palmetto has a similar effect to the drug Finasteride. Finasteride reduces DHT and was originally developed for treatment of prostate cancer, but is effective at treating hair loss caused by DHT. Saw palmetto is a natural, milder treatment for hair loss, with milder effects.

The researchers used 100 male patients that were diagnosed with mild to moderate androgenetic alopecia. The patients were split into two groups, one received saw palmetto (320 mg) and the other received finasteride (1mg).

The researchers concluded that the saw palmetto group experienced a distinct increase in hair growth.

Read more about the research here

Although saw palmetto’s effects are not as significant as Finasteride, it’s side effects are also much less — most people experience no side effects at all.

Saw palmetto extracts have the ability to inhibit both types of 5-α reductase. When patients with androgenetic alopecia took it orally, it enhanced hair growth (2). In another study by Wessagowit and colleagues, 50 male patients with androgenetic alopecia were treated with topical saw palmetto products for 24 weeks. The result showed that the topical products were more effective on patients who didn’t want to take it orally, or can’t tolerate the side effects of oral medications (3).

Zinc

In another research study, Abdel and colleagues compared the levels of serum zinc in patients with alopecia areata with the serum zinc levels in healthy participants. The research team found that serum zinc levels were lower in patients with alopecia areata. They concluded that zinc supplementation might work to reduce hair loss (4).

Green tea

Green tea has also shown a great deal of promise as a natural hair loss treatment. It seems to have DHT blocking properties and contains antioxidants, which which may play a role in protecting cells from free radical damage.

The jury is still out as to whether green tea can help reduce DHT levels though, with one study suggesting in may increase testosterone, which may lead to increased DHT. My research suggests it’s beneficial and will have no detrimental effect on hair growth. See what I think about green tea and DHT here.

Biotin

Sulphur, one of the active components of biotin is involved in the synthesis of collagen, responsible for healthy hair, skin and nails.

Biotin contains sulphur, which is required for hair growth. There are a lot of advocates of biotin on the internet — a lot of people recommend it’s supplementation for increasing hair growth. And research suggests the claims are substantiated.

Biotin plays several roles relating to skin and hair health. It’s required in the production of amino acids. Since hair is made almost entirely of amino acids (particularly cysteine, below), you can see why it’s often cited as an important vitamin for hair growth.

Cysteine

Cysteine is thought to be a very valuable nutrient for increasing hair growth. It’s an amino acid. Amino acids are the basic building blocks of protein. Your body uses these building blocks to build different tyoes of protein. One such protein is hair keratin and cysteine is the main component of it.

Studies have shown that supplementing your diet with cysteine increases hair growth. It’s also a powerful antioxidant and is considered to be very good for liver health.

L-Carnipure

A study in an Oxford lab showed L-Carnitine, in combination with a small amount of potassium, may help “reactivate potassium ion channels” in the hair follicle, which may improve hair health. I have to say this study

Finally, in a comparative study, to evaluate the effects of omega 3&6 supplementation on hair loss. One hundred and twenty healthy women were divided into two groups. The first group received omega 3&6. The second group was the control group. The first group reported a nearly 90% reduction of hair loss (7).

How to use these supplements: the best hair regrowth strategy

You’ve got some really great hair loss supplements on this page. Most of them have similar ingredients but some of them are a bit different. In order to maximize hair regrowth you need to cover all the bases: reduce DHT, increase blood flow to the hair, increase keratin production and improve potassium ion channel function.

Most of these supplements have a suggested dose of 3 capsules/tablets per day. However, I suggest a better strategy is to buy two or three different supplements and mix them up throughout the day to gain more benefit.

Here’s my suggested approach:

Before breakfast

TRX2 powerful hair growth supplement

Before breakfast take one or two TRX2 supplements to activate potassium ion channels in the hair follicles and give your body a dose of biotin and other vitamins to help with biological processes that are required for healthy hair growth.

Lunch time

Reservage Organic Keratin Booster and DHT Blocker

Take one Reservage Organic Keratin Booster and DHT Blocker with lunch to supply your body with keratin needed to produce hair, more biotin, plenty of antioxidants and DHT blockers. If you’re a woman (and therefore have less DHT in your blood) use the standard Reservage Organic Keratin Booster (without DHT blockers).

Evening

Corvinex hair loss supplement

If you’re a man any of the supplements on this page that block DHT would be a good choice to have with your evening meal. If you’re a woman you could either have another TRX2 or Resverage or you could go with a supplement like HairAnew, which contains kelp and silica. Kelp is a good source of iodine, which can be beneficial for woman to help regulate thyroxine.

Why mixing it up may be optimal strategy

In my view the above strategy is better than simply taking one supplement three times per day because you provide your hair with a wider range of nutrients to support hair growth. Providing you take each supplement on its own with a meal at separate times of the day you can avoid mixing nutrients that may either prevent absorption of other nutrients or provide your body with more than it needs of any given nutrient.

Hair Loss and Thyroid: What is the Connection?

Thyroid gland
Source: Wikipedia

Affecting both men and women, thyroid dysfunction can be a significant factor in severe diffuse Alopecia (hair loss). The thyroid gland is a butterfly-shaped endocrine gland located at the front of the neck. It produces, stores, and distributes hormones, altering and controlling the function of almost all of our other glands and the “speed” at which all our cells function, which we refer to as our rate of metabolism. Those with hyperthyroidism are sensitive to heat, seem hungry all of the time and don’t seem to gain weight. Hypothyroidism, on the other hand, creates sensitivity to cold, reduced hunger, and (ironically) weight gain.

Hypothyroidism / Hyperthyroidism

The thyroid can be in any of four states: non-functional, low activity (hypothyroidism), normal (with average production of the two main hormones T3, and T4), and high activity (hyperthyroidism). Its function is affected by certain minerals in our diet, and becomes inefficient when they are in the wrong proportion.

Zinc, Copper and Selenium

Zinc, copper and selenium are particularly important to prevent hair from becoming sparse, thin, and reluctant to grow. One case, of a female, age 28, shows (top images) the thinning hair on top and the receding hairline from the nape of the neck. (Ambooken Betsy, 2013 ) (Gude, 2011)

The bottom portion of each image shows the regrowth accomplished in just one month, and the elimination of the lesions on the neck. (Kumar P, 2012) At first it was unresponsive with thyroid hormone (thyroxine) supplements alone. Once zinc monohydrate was added, aside from the hair regrowth, the facial puffiness, inability to taste food, and chronic depression had such significant improvement that the pre-treatment photographs and post-treatment photographs look like two completely different people.

The thyroid gland creates the hormones which the body needs, when we have enough raw materials such as iodine and zinc. T3 production should generally be 80-200 ng/dl, and T4 should be 4-12 mcg/dl. On a percentage basis T4 comprises 80% and T3 just 20%, but T3 is a much more powerful hormone, so less is needed.

Controlling the thyroid are the hypothalamus and pituitary glands. When thyroid production is too low, the hypothalamus stimulates the pituitary to make TSH (Thyroid Stimulating Hormone) at a level of 0.3-4.5 IU/ml to maintain normal function. When lower levels exist, they have been implicated in Downs Syndrome (Napolitano G, 1990) and numerous other pathologies (Alhaj E, 2007).

The Takeaway

While it is not advised to randomly supplement with mineral additives without some sort of biochemical assessment, upping your daily intake may ultimately be the suggested solution. Consult with your caregiver; you are likely getting some zinc in your diet. Zinc has relatively low toxicity in humans but it is noted as toxic when a dose of more than 225 mg is ingested orally. (Fosmire, 1990)

This is why many denture wearers that use several different brands of denture adhesive seldom have a zinc deficiency. Although manufacturers have been finding alternatives, zinc is often a large component of that class of product because it is highly effective.

In addition, excess levels of zinc also interfere with the absorption of copper and iron, two other minerals which are absolutely vital to good health. Iron supplements can be taken at a completely different time of the day to offset the effect, if necessary. (Greenfield, 2014)

If you eat a well-rounded diet, irrespective of any “fad” aspects, and provide your body with what it needs in order to function properly, you’ll probably have a long healthy life (and a full head of hair), as long as you don’t accidentally step out into traffic… Keep the smartphone in your pocket, look where you’re going, and you’ll be buying shampoo for years to come.

References and further reading

  1. Alhaj E, A. N. (2007, July/August). Diffuse alopecia in a child due to dietary zinc deficiency. SKINmed Dermatology for the Clinician, pp. 6(4):199–200.
  2. Ambooken Betsy, B. M. (2013 ). Zinc Deficiency Associated with Hypothyroidism: An Overlooked Cause of Severe Alopecia. Internation Journal of Trichology, (Jan/Mar) 5(1) 40-42.
  3. Fosmire, G. (1990). Zinc Toxicity. American Journal Of Clinical Nutrition, 51 (2): 225-7.
  4. Greenfield, B. (2014, June 20). A GUIDE TO TIMING SUPPLEMENT INTAKE. Retrieved July 28, 2017, from Labdoor Magazine: https://labdoor.com/article/a-guide-to-timing-supplement-intake
    Gude, D. (2011). Tracing elements in hair. International Journal Trichology, 3:132–3.
  5. Kumar P, L. N. (2012, March 15). Zinc and skin: a brief summary. Dermatol Online Journal, p. 18(3):1.
  6. Napolitano G, P. G. (1990). Is zinc deficiency a cause of subclinical hypothyroidism in Down syndrome? “Ann Genet” [Journal] , pp. 33:9–15.

Does Finasteride Work?

Finasteride

Finasteride is taken as a pill and works by inhibiting the 5-alpha-reductase enzyme responsible for producing DHT. Known more commonly by its brand name, Propecia, finasteride is only FDA-approved for men. In fact pregnant women should not even come into contact with finasteride as it can cause fetal deformities. Many men combine finasteride with an anti-inflammatory shampoo like Nizoral.

The longest clinical trial for a hair loss treatment was for the purposes of evaluating the efficacy of finasteride. In the 1990s, 1,553 men suffering from AGA were given daily one mg doses of finasteride or a placebo over a 12 month period. Each was allowed to enroll in the following one year trial extension, for up to five years. 1,215 men enrolled for the second trial extension, randomized to receive either finasteride or the placebo. Results showed significant hair regrowth for those in the blinded Finasteride group, as opposed to the placebo group. Baseline hair counts averaged 876 hairs in a 1” circle of scalp.

After the first year, finasteride patients averaged an extra 126 hairs in the same area over those taking the placebo. After five years this figure had increased to 277. Examiners recorded that 77% of those on finasteride showed increased hair regrowth after five years. This compared with only 15% in the placebo group.
A further two year trial concentrated on patients with frontal male pattern hair loss. 326 men with either frontal hair loss or thinning enrolled in the trial. Of these half had some vertex hair loss as well. After 12 months, those treated with finasteride showed a relative mean increase of 12 hairs in one cm² compared to those in the placebo group. The study concluded that finasteride slows hair loss and increases hair regrowth in the frontal scalp area.

Used in combination, finasteride really seems to increase hair regrowth for the first year or two. After that there is a more than a two thirds chance of it preventing any further hair loss. Like minoxidil, finasteride probably won’t reverse all hair loss, but for most it will at least stop it dead in its tracks.

Emu oil for hair loss: Is there any evidence it works?

Emu oil for hair loss

In traditional Australian lore, many mystical attributes have been associated with emu oil, including the ability to heal wounds and relieve pain. But recently, there has there been a surge in research focus from scientific circles concerning the therapeutic properties of emu oil; especially relating to hair loss. There have also been increasing number of patents for therapeutic application of emu oil (Holick, 1998; Fein et al., 1995).

Emu oil contains a lot of beneficial fatty acids such as oleic acids (a monounsaturated omega-9 fatty acid) and linoleic acid (omega-6 fatty acid). It has excellent anti-inflammatory properties and has been shown to inhibit TNF-α, a key inhibitory cytokine involved in male pattern balding.

There’s a lot of anecdotal evidence showcasing the ability of emu oil to reduce pain, swelling, stiffness in joints, bruising and other sports-related injuries as well; this has been supported by studies done on rats and mice proving emu oil does have anti-inflammatory agents when applied dermally (Yoganathan et al., 2003; Whitehouse et al., 1998). This anti-inflammatory property is strongly associated with wound healing; wounds (particularly burn wounds) have their healing period accelerated after exposure to emu oil. A study has been done showing emu oil lotion decreasing time taken for wounds to heal(Politis & Dmytrowich, 1998).

Another key property of emu oil is that it is non-comedogenic (doesn’t clog pores). It has a remarkable ability to penetrate the skin (specifically the stratum corneum barrier in the skin) and could potentially act as a transporting agent to help deliver products into the body through the skin. Mineral oil, a current popular carrier oil in cosmetics has been shown to induce pimple formations on skin after applying; emu oil doesn’t as it is highly similar in composition with the skin and hence is highly compatible with our epidermal surface.

Also, emu oil is a good emulsifier. It doesn’t feel oily and is absorbed well into the skin; this is why traditional methods of using emu oil simply involve slathering it on the skin. When converted into cream form emu oil products can be suitable for people who need a non-oily cream for their sensitive skin. Besides that, it is bacteriostatic as the polyunsaturated fats contained in it reduce oxidation and rancidity, ensuring products made from emu oil has a long shelf life and in its pure state prevents the growth of bacterial organisms.

Lastly emu oil is a good moisturiser as it increases the water absorption ability of skin, enabling the skin to retain a youthful appearance which has led to claims of it having anti-aging properties. A double blind study using corn oil as control, found that emu oil stimulated inactive hair follicles to re-activate, making hair follicles more robust and increasing skin thickness and exhibited superior results compared to mineral oil(Zemstov, Gaddis & Montalvo‐Lugo, 1996).

In conclusion, although many claims of the miraculous healing properties of emu oil are likely overblown, it does have several key properties that have been scientifically proven to aid in combating hair loss.

References

  1. Fein, E., Caputo, J., Nagal, A. K. & Nagal, K. (1995) Therapeutic Uses of Emu Oil.
  2. Holick, M. F. (1998) Use of Emu Oil for Stimulating Skin and Hair Growth.
  3. Politis, M. J. & Dmytrowich, A. (1998) Promotion of second intention wound healing by emu oil lotion: comparative results with furasin, polysporin, and cortisone. Plastic and Reconstructive Surgery. 102 (7), 2404-2407.
  4. Whitehouse, M., Turner, A., Davis, C. & Roberts, M. (1998) Emu oil (s): a source of non-toxic transdermal anti-inflammatory agents in aboriginal medicine. Inflammopharmacology. 6 (1), 1-8.
  5. Yoganathan, S., Nicolosi, R., Wilson, T., Handelman, G., Scollin, P., Tao, R., Binford, P. & Orthoefer, F. (2003) Antagonism of croton oil inflammation by topical emu oil in CD-1 mice. Lipids. 38 (6), 603-607.
  6. Zemstov, A., Gaddis, M. & Montalvo‐Lugo, V. M. (1996) Moisturizing and cosmetic properties of emu oil: a pilot double blind study. Australasian Journal of Dermatology. 37 (3), 159-162.

Hair Transplant Discounts & Special Offers, London

Hair transplant discounts and offers

London Hair Transplant Discounts in September 2017

Clinic Name Special Officer/Discount Details
Vinci Hair Clinic 500 pounds off hair transplant procedures after filling out a special form.
White Cliff Hair Solutions “Better Way” pricing available for qualifying customers.
Rejuvenate Hair Clinics Discounted prices for 1000, 2000, and 3000 hair transplants. Only available through Groupon at the moment.
Absolute Aesthetics Complimentary consultation for hair transplant. (Fee of 60 or more pounds waived).

How Much is a Hair Transplant? Costs Across the World Compared

Hair transplant costs

The table below is the first in a series of tables I’ll be publishing to illustrate the costs of hair transplants in different places around the world. You can therefore make a decision as the to most economical place to have your procedure based on your current location.

General overview of costs for world’s biggest clinics

Clinic Name Transplant Price No. of grafts
DRS. TESSLER & ARONOVITZ, P.C. $4.00 per follicular unit
Bernstein Medical, P.C. $350-$550
Feller and Bloxham Hair Transplantation Costs Regular size – Mega Size
La Jolla Hair Restoration Medical Center $5,800 1200 FU
Medical Hair Transplant and Aesthetics $5000-$1000 $4.75 per graft
The Dermatology Center $5 /graft for up to 1,500 grafts
Hair Clinic USA $6500 – $12,500
Haber Dermatology, Inc. $4,000 – $4,000
Hair Sciences Center of Colorado $5-$8/graft
Shapiro Medical Group $5.50 per graft (USD) for the first 2,000 grafts over 2,000, the price drops to $3.00 per graft
North Shore Hair Transplant Specialists With $3 fu/graft and $5-$6 fue/ graft
Lindsey Medical $5,500 – $15,500 800 – 4,000
Parsa Mohebi Hair Restoration $6 per graft
HairTransplant Institute of Miami average cost $7250
Chicago Hair Transplant Clinic Ranges from $2450 – $10000
Carolina Hair Surgery $5,000 1000 grafts
HTS-CLINIC $8,500 2000
HDC Medical Trichology Centre $3.25 Per Graft

Hair Transplant Costs, London

Clinic Name Price Number of Grafts
The Private Clinic of Harley Street £2.50 Per graft
UK Hair Transplant Clinics £3000 Crown Thinning – Number of hairs may vary
Wimpole Clinic £2999 Number of hairs may vary based on consultation
Harley Street Hair Clinic Consultation needed Consultation needed
Vinci Hair Clinic Consultation needed Consultation needed
http://www.crownclinic.co.uk/”>Crown Clinic Consultation needed Consultation needed
Farjo £3,000 Up to 2,200 grafts per day
Rejuvenate Hair Clinics Consultation needed Consultation needed
Restore Hair Clinics Consultation needed Consultation needed
The Maitland Clinic £5 Per graft

Hair Transplant Costs, New York

Clinic Name Price Number of Grafts
Carlos K Wesley Consultation Required Varies person to person
Bernstein Medical Consultation Required Varies person to person
Feller & Bloxham $10 1
Found Hair Consultation Required Varies person to person, but sedation alone is between $800-$1200
True Dorin $7.50-$11 1
NYC Hair Restoration Consultation Required Varies person to person
Ziering Medical $5000-$15000 Varies person to person
Maxim Hair Restoration Consultation Required Varies person to person
New York Hair Loss Consultation Required Varies person to person
Hair Transplant Centre NYC Consultation Required Varies person to person

Hair Transplant Costs, Turkey

Clinic Name Price Number of Grafts
GetFUE Hair Clinics 2,900 € 3500 grafts
Hair Transplant Turkey 3 € Per graft
Este Turkey Consultation needed Number of grafts based on consultation
Best Hair Turkey Consultation needed Number of grafts based on consultation
Civas Hair Transplant 2 € Per graft
Natural Hair Turkey Consultation needed Number of grafts based on consultation
Esthetic Hair Turkey Consultation needed Number of grafts based on consultation
Newage Clinic Consultation needed Number of grafts based on consultation
AEK Hair Institute 3,000 € 5000 grafts
Dr T Hair Transplant Consultation needed Number of grafts based on consultation

Hair Growth Oil: The Most Effective Oils for Hair Growth

Best Hair Growth Oils

Research shows that several natural seed oils contain special chemicals that have been shown to increase hair growth and even reverse hair loss. Of those studied, the following are six of the best in terms of hair growth results.

Peppermint Oil

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A study in 2014 (Oh, Park & Kim, 2014) recently compared the effectiveness of peppermint treatment with 4 other treatment options (including minoxidil, the recommended treatment for hair loss) and found that peppermint exhibited significant increase in dermal thickness, follicle number, and follicle depth compared with other treatments
Read more

Castor Oil

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Castor oil is probably the best oil for increasing hair growth. This is because it contains a large amount of Ricinoleic acid. When Ricinoleic acid is applied to the scalp it has been shown to increase something called PGE2. This is what makes Castor oil a powerful natural hair growth stimulant and hair loss treatment. Increasing PGE2 in the scalp has been shown in studies to promote hair growth and reduce hair loss. Increasing scalp PGE2 is actually one of the key methods for reducing and even reversing hair loss.

Rosemary Oil

/rosemary-oil-proof-of-its-effectiveness/

Rosemary oil was shown in a clinical trial to improve hair growth in 44% of patients experiencing Alopecia.

Pumpkin Seed Oil

/pumpkin-seed-oil-hair-growth-hair-loss-prevention/

Pumpkin seed oil was shown in one study to increase the total hair count in volunteers suffering from hair loss. This is most likely due to high content of the phytosterol beta-sitosterol, which may reduce the production of DHT in the body. DHT is the by-product of testosterone that causes male pattern baldness.

Pumpkin seed oil contains a steroid called delta-7-sterol. This steroid competes against the same receptors in the hair follicle as that of DHT. As a result, DHT may be less likely to bind to hair follicle receptors and therefore less likely to cause hair loss.

Coconut Oil

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Argan Oil

/argan-oil-for-hair-growth-how-it-works-and-how-to-use-it/

Argan oil works by protecting the hair from ‘protein loss’. That means it stops hair from splitting and breaking, which means it can grow longer. A study was conducted on dyed hair to measure whether argan oil would prevent dyed hair from breaking. The study showed the application of Argan oil resulted in a reduction in protein loss from the hair shafts.

Argan oil also contains oleic acid (46-48%) and linoleic acid (31-35%), which have been shown to benefit hair growth.

/olive-oil-hair-growth/

Does Minoxidil Work?

High strength topical minoxidil

Originally a treatment for hypertension, today Minoxidil is marketed as a hair loss treatment. The most well known brand Minoxidil product is called Rogaine. It’s alleged to be medically proven in treating hair loss in both men and women.

When testosterone interacts with the enzyme, 5-alpha-reductase, it creates Dihydrotestosterone (DHT). This hormone runs rampant throughout the body. When it contacts with androgen receptors in the scalp, it causes the hair and follicles to shrink. This leads to the pattern baldness most commonly found in men.

Available in drug stores in two concentrations, 2% and 5%, minoxidil is probably the most common treatment for hair loss. It’s also available in a much higher concentration of 12.5% from some hair loss clinics.

But does it actually work?

100% of patients showed some hair regrowth, although this peaked at 12 months

The first clinical trial on the effect of topical minoxidil on hair loss was carried out in 1987 at Stanford University. The effects of 2 – 3% topical minoxidil was studied on 72 male patients with androgenic alopecia (AGA). The study lasted for 30 months, but 13 patients dropped out during the first year. In the first four months, 100% of patients showed some hair regrowth, although this peaked at 12 months. 70% of patients who applied Minoxidil to their scalps for the full 30 months had 50% more hairs than when they started the trial. A small subset of patients even managed to sustain increases in hair regrowth after 12 months.

In a disappointing turn of events, hair regrowth had returned to baseline levels by week 104.

A clinical trial carried out over 48 weeks in 2002 on 393 men with AGA concluded that 5% topical minoxidil was more effective than 2% in regrowing hair. A similar trial in 2004 carried out on 381 women reached a similar conclusion on the higher concentration.

In 2003, a trial by Pfizer lasting 16 weeks was carried out on 352 male patients. Half received 5% Minoxidil foam, while half received a placebo. Neither group knew what they were receiving, nor in fact did the researchers. The results showed a significant statistical difference in hair regrowth between the groups. The 5% minoxidil group returned 21.0 hairs/cm² after week 16, while the placebo group returned 4.3 hairs/cm² in the same duration.

More recently a 2016 clinical trial evaluated the effects of 5% Minoxidil foam on frontotemporal and vertex AGA in men over 104 weeks. The most significant hair regrowth was found during assessments between weeks 52 and 76. In a disappointing turn of events, hair regrowth had returned to baseline levels by week 104.

These trials seem to show that minoxidil works for more AGA patients than not. Further, the higher the concentrations the greater the hair regrowth. Minoxidil only continues to work while it is still being applied, peaking at one year’s use with a slow decline in regrowth after that. A 5-year follow-up of 31 minoxidil patients in 1990 reached this conclusion. Further, as a 2015 review suggested, cosmetically acceptable results are only achieved by a small subset of patients.

The Best Minoxidil Products

Best topical hair loss treatments

There are no wfar more advanced topical hair loss treatments than basic Minoxidil products. To see the world’s most advanced Minoxidil treatments click here.

Garlic for Hair Loss: Why it Works and How to Use It

Garlic

The bioactive components of garlic have been extensively researched and have been proven to have many therapeutic and preventative effects on various diseases and health problems (Santhosha, Jamuna & Prabhavathi, 2013). Recently, a study has found that garlic oil has significant effects on treating alopecia areata, a recurring, non-scarring type of hair loss which results in coin-sized patches of baldness on the individual (Hajheydari et al., 2007). The study was done on a sample size of 40 patients (20 control and 20 treated with garlic treatment) with significant improvements observed in 90% of the patients after three months and no recorded side effects. This study serves to bolster anecdotal claims of garlic containing hair-stimulatory effects.

A rich source of sulphur, vitamin C and iron: KEY hair growth nutrients

Sulphur: anti inflammatory and key component of keratin

Garlic has high levels of sulphur, Vitamin C and iron, all of which have been proven to aid in combating hair loss. Sulphur from garlic has been shown to have anti-inflammatory effects which prevents inflammatory disorders from targeting hair follicles and prevents hair from growing (Lee et al., 2012). It is also one of the main building blocks of keratin which constitutes our hair, nails and other epidermal tissues; deficiencies can result in hair loss and brittle nails.

Vitamin C:

In a study by Sung et al., ascorbic acid 2-phosphate, a derivative of Vitamin C, was used to treat patients with androgenic alopecia (2006). The study found that there was “significant growth stimulation” in the cells located in the scalp, and the study eventually concluded that the vitamin C derivative promoted hair follicle growth in hair follicles.
Read more

Vitamin C which is an essential water-soluble vitamin that cannot be produced by our bodies is also found in garlic, which enhances the absorption of iron and is needed for a wide range of bodily functions (Weber, Bendich & Schalch, 1996). It enhances the development of hair and increases the strength of hair structures.

Anti-fungal properties

Garlic has anti-fungal properties due to the presence of allicin, an oxygenated sulphur amino acid which is produced when garlic is crushed (Ankri & Mirelman, 1999). Upon crushing, an enzyme rapidly converts allicin from its stable precursor alliin into the more biologically active allicin, which exhibits antibacterial activity against a wide range of Gram positive and Gram negative bacteria such as E. Coli and Candida albacans. This is important in the treatment of hair loss due to the presence of a naturally occurring fungus, Malassesia globose, which breaks down the oil on the scalp leading to hair loss.

How to apply garlic to make hair grow

There are several methods available to apply garlic juice to your scalp. The most straightforward method is to rub garlic bulbs on the skin and wash after 10 minutes. However, in order to obtain greatest effect, it is recommended to use crushed garlic juice as the crushing process activates enzymes contained in the garlic. It must be noted that crushed garlic juice is incredibly potent and will likely result in skin irritations if applied directly; hence it is recommended to mix with other substances in order for it to work as a topical treatment. Common options are honey, coconut oil and even simply soaking the bulbs in oil overnight and applying the resulting concoction.

In conclusion, garlic has been shown to have beneficial impact on hair growth and can serve as an easy, effective and hence attractive alternative to conventional medicine with regards to treating hair loss.

References

  1. Ankri, S. & Mirelman, D. (1999) Antimicrobial properties of allicin from garlic. Microbes and Infection. 1 (2), 125-129.
  2. Hajheydari, Z., Jamshidi, M., Akbari, J. & Mohammadpour, R. (2007) Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study. Indian Journal of Dermatology, Venereology and Leprology. 73 (1), 29-32.
  3. Lee, D. Y., Li, H., Lim, H. J., Lee, H. J., Jeon, R. & Ryu, J. (2012) Anti-inflammatory activity of sulfur-containing compounds from garlic. Journal of Medicinal Food. 15 (11), 992-999
  4. Santhosha, S., Jamuna, P. & Prabhavathi, S. (2013) Bioactive components of garlic and their physiological role in health maintenance: A review. Food Bioscience. 3, 59-74.
  5. Weber, P., Bendich, A. & Schalch, W. (1996) Vitamin C and human health–a review of recent data relevant to human requirements. International Journal for Vitamin and Nutrition Research.Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung.Journal International De Vitaminologie Et De Nutrition. 66 (1), 19-30.

Stress is Causing Your Hair Loss: Here’s Why

How does stress causes hair loss

Every hair follicle experiences three stages: growth (anagen), involution (catagen), and resting (telogen). The growth stage may last for 2 to 6 years. Then the involution stage is about a couple of days. The hair follows the next step, going into the resting phase and finally, the hair falls out. Each person may lose from 50 to 100 hairs a day normally (flow chart below) (2).

Stages of hair growth

In order to treat your stress related hair loss, you need to know what type of hair loss you have. Otherwise you may waste months or even years incorrectly treating your hair loss, when you could have simply changed the treatment and solved the problem quickly.

I believe that four types of hair loss may be caused (or exacerbated) by stress or anxiety: Telogen effluvium (TE), trichotillomania, alopecia areata (3) and androgenic alopecia.

Telogen Effluvium

This occurs when the growth phase is abnormally short, resulting in large numbers of hair follicles prematurely entering the resting phase. A great many hairs will fall out suddenly during daily routines when you comb or wash your hair (2). Women tend to suffer from this condition more than men (4).

Emotional stress is the most common causes of TE (Table below) (2). This stress may act as a primary factor for hair loss, or a secondary factor as a response to hair loss. Stress is considered a negative hair growth factor which has an adverse impact on the life cycle of a human’s hair (5).

Causes of tellogum efflum

Acute TE is a self-limiting condition, and eventually, it goes away by itself. Therefore, we only observe the symptoms until it heals spontaneously. There are not many treatment options for chronic TE. But as you’ll see at the end of this article there are powerful ways to limit the condition.

Trichotillomania

Trichotillomania is an urgent desire to pull out your hair in response to a stressful situation. Hair pulling can be a way of handling negative or uncomfortable feelings, such as stress, tension, loneliness, boredom or frustration. It occurs more often in women than in men (2).

Sixty-five percent of patients with trichotillomania were diagnosed with obsessive compulsive disorders and anxiety disorders (6). In a study by Grant and colleagues, roughly 530 adults with trichotillomania were examined in a variety of clinical interventions including symptom severity, psychosocial measures of functioning, psychiatric comorbidity and neurocognitive testing assessing motor inhibition and cognitive flexibility. The result showed that those with major depressive disorder (MDD) had worse symptoms than those with an anxiety disorder only, and patients with MDD and an anxiety disorder suffered the most severe symptoms (7).

In situations where an individual suffers Trichotillomania, clearly treating the underlying psychological problems is far more important than focusing on the hair loss. And since the underlying cause of the hair loss is psychological, that is precisely where treatment should be focused.

Alopecia Areata

There are thought to be a variety of causes of alopecia areata including severe stress and anxiety. In alopecia areata, the hair follicles are damaged by the immune system, thereby causing hair loss.

Alopecia areata happens in 2 percent of the general population, and the rate of men and women is equal. The disease may be present at any age but is more common in children and young adults (8).

In a clinical study, the research team compared the mental health of patients with alopecia areata with the healthy population. There were significant differences between two groups, i.e. the result demonstrated the rate of anxiety and depression was higher in patients with alopecia areata (9). Sellami and colleagues conducted another clinical study to investigate the relationship between alopecia areata and emotional disorders such as alexithymia, anxiety, and depression. They showed again that patients with alopecia areata had a high rate of anxiety and depressive manifestations (4).

Androgenic Alopecia

Though the primary cause of androgenic alopecia is the hormone Dihydrotestosterone (DHT), there is strong evidence to suggest that DHT is increased in the blood by increased presence of the stress hormone cortisol. Therefore, it seems salient to suggest adrogenic alopecia (hair loss induced by adrogen hormone) is exacerbated by increased cortisol hormone. We might even go so far to say that androgenic alopecia would not occur at all if it weren’t for elevated cortisol interacting with testosterone to result in elevated serum DHT — though there is as yet limited evidence to prove this.

Conclusions

In a nutshell, there is a high likelihood that those with mild anxiety-induced hair loss are suffering from telogen effluvium, i.e. simply stress-weakened hair. However, the other three conditions, trichotillomania, alopecia areata and adrogenic alopecia have been raising concerns for human beings, notably for the high stress categories of the population.

Since elevated DHT is also linked to prostate cancer, stress should be considered of high importance in the treatment and prevention of disease.

References

  1. Hunt N, McHale S. The psychological impact of alopecia. BMJ. 2005;331(7522):951-3.
  2. Thiedke CC. Alopecia in women. American family physician. 2003;67(5):1007-14.
  3. K. D. Can stress cause hair loss? Mayo Clinic2016 [Available from: http://www.mayoclinic.org/healthy-lifestyle/stress-management/expert-answers/stress-and-hair-loss/faq-20057820.
  4. Sellami R, Masmoudi J, Ouali U, Mnif L, Amouri M, Turki H, et al. The relationship between alopecia areata and alexithymia, anxiety and depression: a case-control study. Indian journal of dermatology. 2014;59(4):421.
  5. Grover C, Khurana A. Telogen effluvium. Indian J Dermatol Venereol Leprol. 2013;79(5):591-603.
  6. Grzesiak M, Reich A, Szepietowski JC, Hadrys T, Pacan P. Trichotillomania Among Young Adults: Prevalence and Comorbidity. Acta dermato-venereologica. 2017;97(4):509-12.
  7. Grant JE, Redden SA, Medeiros GC, Odlaug BL, Curley EE, Tavares H, et al. Trichotillomania and its clinical relationship to depression and anxiety. International journal of psychiatry in clinical practice. 2017:1-5.
  8. Bertolino AP. Alopecia areata. A clinical overview. Postgraduate medicine. 2000;107(7):81-5, 9-90.
  9. Baghestani S, Zare S, Seddigh SH. Severity of Depression and Anxiety in Patients with Alopecia Areata in Bandar Abbas, Iran. Dermatology reports. 2015;7(3):6063.

Borage Oil as a Hair Loss Treatment: All the Facts

Borage oil

Borage Oil, also known as Starflower Oil, comes from the Borago officinalis flower and is thought to treat a wide array of issues, including Athsma, Arthritis, and improving brain function. However, there is little to no evidence to support these claims.

There’s a widespread idea that Borage Oil is a great treatment for hair loss, and specifically Male Pattern Hair Loss. It is believed that taking supplements or applying borage oil topically to the scalp will help you to regrow lost hair, or at least prevent hair loss.

Borage oil is a rich source of Gamma-Lenolenic Acid (GLA)

According to a 2017 study of diet and hair loss, entitled Diet and hair loss: effects of nutrient deficiency and supplement use:

Deficiency of the polyunsaturated essential fatty acids linoleic acid (an omega-6 fatty acid) and alpha-linolenic acid (an omega-3 fatty acid) can… include loss of scalp hair and eyebrows as well as lightening of hair. Unsaturated fatty acids may…may promote hair growth by enhancing follicle proliferation

Due to a lack of Omega 6 Fatty Acids in the body, the body reacts in many ways, including the shedding and thinning of hair. This shedding and thinning reverts or stops when Omega 6’s are included back in the diet.

A natural DHT blocker (5 alpha reductase inhibitor)

Another theory is that the GLA in Borage Oil suppresses DHT, or DiHydroTestosterone, which is associated with male baldness. There seems to be some kind of truth to this as well, as GLA does indeed suppress some DHT, but there is little evidence that taking a GLA supplement reduces instances of male pattern baldness.

DHT is held responsible for miniaturization of hair follicles in AGA [(Androgenic Alopcecia)]. However, as DHT is a more potent form of testosterone and androgens are expected to convert hair follicles from vellus to terminal not the other way around,” According to one study showcasing the paradox of DHT and hair loss.

There are also potential side effects with taking Borage Oils that contain Pyrrolizidine Alkaloids (PA), which is a common chemical in the plant. PA’s can damage the liver if taken orally.

The medical and scientific literature is lacking on the effectiveness of this oil for pretty much any health claim attributed to it, and more studies and evidence needs to be done to show any of these theories to be accurate.

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174066/
  3. https://www.ncbi.nlm.nih.gov/pubmed/12589947
  4. http://www.webmd.com/vitamins-supplements/ingredientmono-596-borage.aspx?activeingredientid=596&activeingredientname=borage

Capixyl for Hair Loss: As a DHT Inhibitor

Kevis 8 hair loss treatment

Capixyl is a recently launched product that targets one of the most common mechanisms that is involved in hair loss. It reduces the production of dihydrotestosterone (DHT) which causes miniaturization of hair follicles thus causing hair loss.

Capixyl is mainly composed of two active ingredients; namely AcetylTetrapeptide-3 and Trifolium Pratense. Other components include water, butylene alcohol, and dextran. Water and butylene alcohol are solvents for the active ingredients while dextran increases the viscosity of the product.

Both ingredients in Capixyl works synergistically. Biochanin A which is the active ingredient in Trifolium Pratense in an effective inhibitor of 5α reductase activity thus inhibiting the production of DHT. Acetyl tetra peptide-3 is a biomimetic peptide that is synthesized in the laboratory and mimics the behavior of a natural peptide. It remodels the hair follicle proteins and causes better healing of the tissue.

Following are the effects seen with the use of capixyl in laboratory studies:

It has shown a clear increase in Anagen hair density thus promoting hair growth. A decrease in the Telogen hair density shows decreased hair loss. When the peptide acts synergistically with biochanin A, it has shown to be more effective in reducing pro inflammatory cytokines thus reducing inflammation in the scalp. Acetyl tetrapeptide-3 renews and remodels extracellular matrix and promotes the production of anchoring proteins thus leading to better hair follicle size and better anchoring. It also works on the dermal epidermal junction by promoting the formation of Collagen VII. All these effects combined leads to healthier and thicker hair with greater anchorage. Capixyl has an excellent safety profile. It is skin tolerant and is also safe to use around eyes.

References

  1. Alopecia treatment for women with hair Capixyl, PR Newswire. (2016). Retrieved from: http://www.prnewswire.com/news-releases/alopecia-treatment-for-women-with-hair-capixyl-144317855.html
  2. Capixyl, anti-aging hair care complex. Retrieved from: https://cdn.shopify.com/s/files/1/0319/8073/files/Capixyl_marketing_brochure__low_res.pdf
  3. Capixyl. Retrieved from: http://usuge-nukege-taisaku.com/wp-content/uploads/2717fd581468bcfd494ad621e7a24bc0.pdf
  4. How does it work, The Brighton hair loss clinic. Retrieved from: https://www.thebrightonhairlossclinic.co.uk/how-does-it-work/
  5. Herskovitz, Ingrid and Tosti, Antonella. 2013. Female pattern hair loss, International journal of endocrinology metabolism , 11(4).
  6. Levy, L. Lauren and Emer J.Jason. (2013) .Female pattern alopecia, International journal of womens health, 5(541-556).
  7. Loma. (2016). Hair loss treatment with capixyl. Retrieved from: http://hairmomentum.com/hair-loss-capixyl/

Capsaicin/Cayenne for Hair Loss Prevention and Hair Growth Promotion

Chilli Pepper

Capsaicin is a chemical compound which is present in almost all kinds of peppers. It’s responsible for making the peppers spicy.

Capsaicin activates ‘vanilloid receptor 1’.

The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers
(Bodo et.al, 2005)

The activation of vanilloid receptor 1 causes the sensory neurons to release the calcitonin gene related peptide (CGRP). It’s the calcitonin gene related peptide which is believed to enhance the production of the insulin like growth factor (IGF-1).

Synergistic combination of capsaicin and isoflavone

Soy Isoflavones

Along with capsaicin, isoflavone plays an important role by increasing the production of CGRP.

The study stated, “These observations strongly suggested that combined administration of capsaicin and isoflavone might increase IGF-I production in hair follicles in the skin, thereby promoting hair growth” (Harada et.al. 2007).

The group of mice which were given capsaicin found to undergo more rapid hair growth as compared to the other group which were controlled and not given the capsaicin.

References

  1. Harada, N., Okajima, K., Arai, M., Kurihara, H., & Nakagata, N. (2007). Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia. Growth Hormone & IGF Research, 17(5), 408-415.
  2. Bodó, E., Bíró, T., Telek, A., Czifra, G., Griger, Z., Tóth, B. I., … & Paus, R. (2005). A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. The American journal of pathology, 166(4), 985-998.

Onion Juice for Hair Growth and Hair Loss Prevention: Fact or Fiction?

Onion

You might be surprised to hear the humble onion is used by thousands of people around the world to promote hair growth. This versatile staple, which has been cultivated for over 5,000 years, is believed by many to not only stop hair loss but even promote its regrowth.

So does it work?

What’s In Onion Juice That Helps Hair?

High sulfur content may directly build hair keratin

MSM Powder

The key ingredient in onion juice believed to remedy hair loss is sulfur. Onions are 89% water, but they contain high levels of sulfur. Garlic, a species of the same Allium onion genus, is also sulfur-rich and also mooted as a cure for hair loss, although less well known as onion.

It’s believed that supplementing the levels of sulfur in your body can contribute to hair growth. Sulfur is stored in the body as an organic compound called methylsulfonylmethane (MSM). The compound breaks down, releasing sulfur, which helps grow hair, bone and nails.

Amino acids for hair growth

To learn more see MSM for Hair Growth: A Complete Guide.

But the substance which gives skin, nails and hair increased resilience and strength is keratin.

Keratin is composed of strong protein fibers which help protect epithelial cells. The amino acids which make up these keratin proteins contain high levels of sulfur.

Anti-bacterial properties may protect scalp from infection

A study has also proven the antibacterial properties of onion juice. Even after 48 hours, extracts of onion at room temperature were shown to have an antibacterial effect on common bacterial strains. Hair needs a healthy scalp and follicles to grow strongly, so this ability to fight infections may have a positive effect on hair growth.

High antioxidant content may protect scalp and follicles from free radicals

A further study has revealed the onion to be one of the richest sources of dietary flavonoids. These antioxidants neutralize free radicals, the molecules that lead to premature ageing. Free radicals may have a negative effect on hair follicle development, reducing hair regrowth.

Reducing scalp inflammation

It is believed that scalp inflammation is one of the key causes of male pattern hair loss. Fortunately, the sulfur found in onion works as an anti-inflammatory agent, further helping to create a healthy scalp environment.

Sulfur deficiency

For people with a sulfur deficiency, increasing sulfur in the diet will almost certainly help regenerate hair follicles and promote hair growth.

The studies cited show that onion juice contains substances which are powerful weapons for treating hair loss. We know as well that onion is a great source of minerals, including potassium, germanium, calcium and manganese. Onion is also rich in vitamins B6 and C. These all help to nourish the scalp and combat hair loss.

Have there been any studies which actually prove the effectiveness of onion juice in treating hair loss? There has been only one so far, carried out in Baghdad Teaching Hospital, Iraq.

Study Shows Onion Juice Reverses Alopecia Areata

The study found that there was some regrowth of terminal coarse hairs after only two weeks

In June 2002, the Journal of Dermatology published a study exploring how effective onion juice is in treating alopecia areata. It’s important to note that alopecia areata is a different hair loss to the much more common male-pattern baldness.

Alopecia areata is a patchy hair loss condition which can occur on areas of the body outside the scalp. It can affect people of all age and ethnic groups, as well as both sexes. It occurs when the immune system attacks the body’s hair follicles, suppressing hair growth. This results in small patches of hair loss, which are usually not permanent.

Male-pattern baldness is a hereditary condition though which is permanent, and results in complete loss of hair around the crown of the head and the temples. Known also as androgenetic alopecia, predisposition depends on levels of the male sex hormone, DHT and levels of the stress hormone cortisol — as well as several other factors.

In the study, participants were divided into two groups. 23 patients aged between five and 42 made up the first group, 16 males and seven females. This group was asked to apply an onion juice treatment twice daily for two months. Eight males and seven females, aged between three and 35 years, formed the second, control group. They applied tap water to their scalps at the same intervals as the first group.

The study found that there was some regrowth of terminal coarse hairs after only two weeks in some of the group using onion juice. After four weeks, hair regrowth was observed in 17 patients, almost three quarters of the total group. Finally after six weeks, hair regrowth was observed in 20 patients, almost 90% of the total.

Hair regrowth in the control group using tap water was restricted to just two patients after eight weeks, one male and one female. Perhaps surprisingly for the group using onion juice, males outperformed the females in hair regrowth. Only one of the 16 males in the group failed to regrow hair; while two out of 7 females failed to do so. The results of this study suggest that crude onion juice is much more effective in treating patchy alopecia areata than tap water.

While this is the only known study to have been carried out to show the effectiveness of onion juice on hair loss, the results are very encouraging. It should be remembered though that the type of hair loss suffered by the study’s participants was the transitory alopecia areata. For male-pattern baldness, where DHT is the main offender, no such encouraging research results have been forthcoming. Still, onion juice can help to reduce both follicle inflammation and the levels of DHT found on the scalp. This means that sulfur-rich onion juice might at least slow the effects of male-pattern baldness, which will be a comfort to many even if it’s not a cure.

Further reading

  1. https://www.hairlossrevolution.com/onion-juice-hair-results/
  2. https://www.ncbi.nlm.nih.gov/pubmed/12126069
  3. http://www.balancemebeautiful.com/onion-juice-promotes-hair-growth/
  4. https://www.ncbi.nlm.nih.gov/pubmed/9354029
  5. http://www.hairbuddha.net/use-onion-juice-hair-growth/
  6. https://en.wikipedia.org/wiki/Onion
  7. https://www.researchgate.net/publication/273758703_Onion_Juice_An_Effective_Home_Remedy_for_Combating_Alopecia
  8. https://www.onions-usa.org/all-about-onions/history-of-onions
  9. https://www.ncbi.nlm.nih.gov/pubmed/17997520?dopt=Abstract
  10. https://www.reference.com/science/keratin-found-body-6d99a3dc0bce9ac
  11. https://en.wikipedia.org/wiki/Alopecia_areata

Pygeum For Hair Loss: Better Than Saw Palmetto?

Advanced trichology dht blocker supplement

Pygeum is an extract from the bark of Prunus Africana known in English as the African Plum Tree and has become popular in the last decades due to studies showing its anti-androgenic effects.

The extract, the fruits as well as the bark of the tree have been used as a traditional medicine in Africa for centuries to treat different ailments such as infections and inflammation. Pygeum extract shows promise as a natural treatment for hair loss due to its DHT blocking effects. Whether its effects are due to its fatty acids, anti-inflammatory properties or the beta-sitosterol in contains (Stewart, 2003) remains to be researched further, but there are numerous studies showing its potential DHT inhibiting properties in patients suffering from an enlarged prostate and even from prostate cancer.

DHT Inhibitor

The authors mention that this particular mechanism is similar to the one of finasteride and could lead to developing a new similar drug without the severe side effects

Hair follicles in the scalp can be sensitive to DHT, which causes them to miniaturise over time, gradually making hair thinner and eventually causing baldness.

Androgenic alopecia’s pathogenesis is androgen dependent, meaning that the androgen receptor (AR) gene is one of the main culprits for its early onset (Hilmer et al., 2005). This may be one of the reasons why pygeum is an effective treatment for hair loss as researchers noticed that it inhibits the human AR, which contributes to growth of the prostate gland and to alopecia.

N-butylbenzene-sulfonamide

The 5 alpha-reductase (5AR) inhibiting mechanism is due to the isolated N-butylbenzene-sulfonamide (NBBS) compound in pygeum, which is a specific AR antagonist. (Papaioannou et al., 2010)

Cysteine, lysine and serine

A scientific paper (Cabeza et al., 2016) reviewed drugs used for androgen dependent diseases. Among them, Pygeum’s mechanism that enables the inhibition of the 5AR enzyme is based on the formation of an enzyme steroid complex with a nucleophilic part composed of substances like cysteine, lysine and serine. The authors mention that this particular mechanism is similar to the one of finasteride and could lead to developing a new similar drug without the severe side effects.

Pygeum and nettle

the best results were seen when they were used together

Pygeum is more effective than nettle. Nettle and pygeum combined are more effective than pygeum alone.

Other studies seem to confirm these effects: when pygeum was studied in relation to nettle root extracts, researchers found that they significantly blocked the action of 5 alpha reductase and aromatase, which caused a decrease in DHT. When nettle root and pygeum effects were compared against each other, pygeum extract was the one showing higher efficacy even in low doses, but the best results were seen when they were used together. (Ghorbanibirgani et al., 2013; Hartman et al., 1996)

Pygeum compared to Finasteride, saw palmetto and Tamosuosin

Pygeum: 43.3% improvement. Finasteride: 57% improvement. Saw palmetto: 42.7% improvement.

In another study (Hutchinson et al., 2007), 2559 patients suffering from BPH and following a various set of treatments were compared with patients that were simply supervised without following any treatment. The treatments followed by the first group included: finasteride, saw palmetto, tamosulosin, and pygeum. After a year, there was a significant improvement registered for the group that received treatment when compared to the untreated group but the results varied according to the type of treatment received. Those who were taking a treatment involving pygeum had 43.3% improvement, comparable to the results for finasteride (57% improvement). Also, the patients that were receiving pygeum africanum had a slightly better improvement rate when compared to those who were treated with saw palmetto (42.7 %).

These studies confirm that pygeum may have similar, if not better effects than saw palmetto. This, however, also depends on the dosage and each individuals, as some might respond better to one plant than the other.

Antioxidant and anti-inflammatory properties

Besides being a 5AR inhibitor, pygeum is also a good source of antioxidants which may help nourish hair and protect it from free radicals. Various studies (Oktay et al., 2003; Steenkamp et al., Feng et al., 1995) have shown that the extract of pygeum has excellent antioxidative properties.

Studies on animals have shown that pygeum has a significant anti-inflammatory activity by decreasing the production of leukotrienes, 5-lipoxygenase metabolites and inhibiting fibroblast production. (Boulbès et al., 2006)(Quiles et al.,2010) Other studies (Cristoni et al.,2000, Stewart,2003) have also confirmed these anti-inflammatory effects. Since people with hair loss usually present significant inflammation of the scalp, pygeum could also be used as an adjuvant in hair loss treatments. Furthermore, these beneficial effects make pygeum a superior treatment to saw palmetto since it also reduces inflammation.

Dosage

As for dosages, in most studies, pygeum is taken in two 200mg doses per day as a maximum dosage but studies have shown that a single dosage of 100mg per day or two dosages of 50mg per day have shown significant effects and are safe even after a 12 months of continuous usage. (Chatelain et al., 1999) The extract can be found on its own or part of a supplement either for hair loss or prostate enlargement, in combination with other natural ingredients such as saw palmetto or nettle root.

The side effects when taking this extract have been shown by most studies to be minimal and mostly include a mild stomach upset.

Best Pygeum supplements for hair loss

Below are what I consider to be some of the best DHT blocker supplements that contain pygeum.

  • Advanced trichology dht blocker supplement

    Advanced Technology DHT Blocker with Immune Support
    $36 for 120 Capsules

    This is a superb all round DHT blocker supplement. Not only does it contain a powerful blend of DHT blocker ingredients; it also contains probiotics, which help improve intestinal health and support an alkaline PH level, which may be beneficial for healthy DHT levels.It also contains the amino acid lysine, which studies show, increases hair growth. This is a top DHT blocker supplement.

    Ingredients

    Buy online (USA)

  • Hairomega DHT supplement

    Hairomega 3-in-1 DHT blocker $20 for 120 Tablets

    Hairomega’s DHT blocker not only blocks DHT but increases blood flow to the scalp using various polyphenols, which aid in further hair growth once the hair follicles are restored. There are even other beneficial vitamins in the pill for your overall health, making this supplement a fantastic option for a DHT blocker!

    • Contains vitamins and minerals that support hair growth
    • Contains several potent ingredients that are strongly believed to reduce serum DHT
    • Contains quercetin, green tea, raspberry and broccoli, which are high in antioxidants
    • Contains mushrooms and herbs, which may benefit hair growth

    Ingredients

    Buy online (USA)

    Buy online (UK)

  • Folliform DHT Blocker supplement

    Folliform DHT Blocker for Men and Women
    $29.99 for 60 Capsules

    Folliform DHT Blocker uses saw palmetto, nettle root extract, green tea, pumpkin seed, pygeum extract, and zinc oxide to help with hair growth. These ingredients form a natural DHT blocker, meaning that not only will your hair grow longer, but you’ll also only be adding all-natural ingredients to your body. Many users have seen not only hair growth, but improvement in nail health as well (which is just an added bonus!)

    • All the ingredients used in this supplement are strongly believed to reduce serum DHT
    • Green tea contains antioxidants, which may also be beneficial for hair growth

    Ingredients

    Buy online (USA)

Pygeum is an endangered species

Whatever product you choose, make sure that the pygeum is extracted from a responsible source; since the pygeum plant is an endangered species.

Conclusions

Pygeum africanum could be a potential treatment for hair loss due to its DHT inhibiting effects but also due to the fact that it may also reduce inflammation in the scalp. Further research is needed to completely understand the substance’s potential and efficacy but its effects are similar to saw palmetto and even superior according to one study, which compared the both. Fortunately, the extract is safe to take as a supplement so those suffering from androgenic alopecia should try it on its own or in combination with other treatments they are taking. As a precaution, always ask your physician before taking any supplements, especially if you follow other treatments.

Most importantly, make absolute certain you tell your doctor that you’ve taken pygeum supplements before having your prostate examination — pygeum is likely to effect prostate size and therefore may influence the result of your prostate exam.

References

  1. Stewart KM. The African cherry (Prunus africana): can lessons be learned from an over-exploited medicinal tree? J Ethnopharmacol 89 (2003):
    3–13. Shenouda N., Sakla M., Newton L., et al. Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo. Endocrine. 2007;31(1):72–81. doi: 10.1007/s12020-007-0014-y. [PubMed]
  2. Wilt T., Ishani A., Mac Donald R., Rutks I., Stark G. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst. Rev. 2002;1:CD001044. [PubMed]
  3. Hillmer, A. M., Hanneken, S., Ritzmann, S., Becker, T., Freudenberg, J., Brockschmidt, F. F., … Nöthen, M. M. (2005). Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia. American Journal of Human Genetics, 77(1), 140–148.
  4. Schleich S., Papaioannou M., Baniahmad A., Matusch R. Activity-guided isolation of an antiandrogenic compound of Pygeum africanum. Planta Medica. 2006;72(6):547–551. doi: 10.1055/s-2006-941472.
  5. Oh B.R., Kim S.J., Moon J.D., Kim H.N., Kwon D.D., Won Y.H. Association of benign prostatic hyperplasia with male pattern baldness. Urology. 1998;51:744–748. [PubMed]
  6. Amoretti A., Laydner H. & Bergfeld W. Androgenetic alopecia and risk of prostate cancer: A systematic review and meta-analysis. J. Am. Acad. Dermatol. 68, 937–943 (2013). [PubMed]
  7. Steenkamp V, Gouws MC, Gulumian M, Elgorashi EE, Van Staden J. Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. J Ethnopharmacol. 2006;103:71–75. doi: 10.1016/j.jep.2005.07.007.
  8. Boulbès D, Soustelle L, Costa P, Haddoum M, Bali JP, et al. Pygeum africanum extract inhibits proliferation of human cultured prostatic fibroblasts and myofibroblasts. BJU Int. 2006;98:1106–13.
  9. Quiles MT, Arbos MA, Fraga A, de Torres IM, Reventos J, et al. Antiproliferative and apoptotic effects of the herbal agent Pygeum africanum on cultured prostate stromal cells from patients with benign prostatic hyperplasia (BPH) Prostate. 2010;70:1044–53. [PubMed]
  10. Cabeza, M., Sánchez-Márquez, A., Garrido, M., Silva, A., & Bratoeff, E. (2016). Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases. Current Medicinal Chemistry, 23(8), 792–815. http://doi.org/10.2174/0929867323666160210125642
  11. Ghorbanibirgani, A., Khalili, A., & Zamani, L. (2013). The Efficacy of Stinging Nettle (Urtica Dioica) in Patients with Benign Prostatic Hyperplasia: A Randomized Double-Blind Study in 100 Patients. Iranian Red Crescent Medical Journal, 15(1), 9–10. http://doi.org/10.5812/ircmj.2386
  12. Hartmann RW, Mark M, Soldati F. Inhibition of 5-alpha-reductase and aromatase by PHL-0081, a combination of PY102 (Pygeum africanum) and UR102 (Urtica dioica) extracts. Phytomedicine. 1996;3(2):121-8.
  13. Chatelain C., Autet W., Brackman F. (1999). Comparison of once and twice daily dosage forms ofPygeum africanum extract in patients with benign prostatic hyperplasia: a randomized, double-blind study, with long-term open label extension. Urology 54 473–478. 10.1016/S0090-4295(99)00147-8

Pumpkin Seed Oil for Hair Growth & Hair Loss Prevention

Pumpkin seed oil

Pumpkin seed oil has been proven scientifically to improve the hair count and prevent hair loss while increasing hair thickness. This article will discuss the scientific studies and show exactly how pumpkin seed oil can be effective for hair growth.

The most common form of hair loss is Andogenic Alopecia (AGA). This is hair loss caused by the hormone DHT. According to various scientific studies, AGA affects approximately 70% of men in their later life particularly after the age of 50 years. However I would estimate it to be a far greater number and a much lower age. Androgens and genetic factors primarily underline the pathogenesis of Androgenic alopecia (Semalty, Semalty, Joshi, & Rawat, 2011). The hair follicles spend less time in their active growth phase and gradually ‘miniaturize’ over a period of years.

AGA usually effects the temples first and continuous through time to effect all of the top of the scalp. Eventually, this leads to complete loss of the hair on the top of the scalp, while the back and sides may remain fairly normal.

What anti hair loss properties does pumpkon seed oil have?

Pumpkin seed oil is obtained by pressing hulled pumpkin seeds, which are a rich source of essential fatty acids, antioxidants and minerals. Along with being a delicious plant, pumpkin is also recognized as having medicinal properties, including anti-carcinogenic, anti-inflammatory and anti-diabetic.

Studies have shown pumpkin seed oil is effective in battling hair loss

A clinical study was carried out that investigated the efficiency of pumpkin seed oil for the treatment of hair loss and AGA in particular. The study was conducted in a randomized manner during a 24-week period (Cho, Lee, Jeong, & Choi, 2014). The study included 76 male subjects suffering with moderate AGA. The study evaluated the effects using a process called phototrichography, which helps us analyse changes in hair including hair diameters and hair counts. The analysis was performed before starting the trial and again at the end. The results revealed that pumpkin seed oil treatment increased hair count in several of the study participants.

Pumpkin seed oil offers a natural and safe way for preventing hair loss. It also has a long list of other health benefits and no unwanted side effects.

How does pumpkin seed oil prevent/reduce hair loss?

There are number of components present in pumpkin seed oil that can assist in hair loss prevention.

Phytosterol beta-sitosterol

It contains phytosterol beta-sitosterol which lessens damage caused to the hair by the DHT by preventing the conversion of testosterone to DHT (Semalty, Semalty, Joshi, & Rawat, 2011).

Delta-7-sterol

Pumpkin seed oil contains a steroid called delta-7-sterol. This steroid competes against the same receptors in the hair follicle as that of DHT. As a result, DHT may be less likely to bind to hair follicle receptors and therefore less likely to cause hair loss.

Important minerals required for hair growth

Pumpkin seed oil contains minerals like magnesium and zinc. Both magnesium and zinc are among two essential minerals for skin and hair care. Zinc not only increases the thickness of hair but it also speeds up growth.

To conclude, various studies have shown that pumpkin seed oil could be helpful in improving AGA and it could be considered as a potential treatment for hair loss. Pumpkin seed oil is found to play an important role in hair loss by effecting testosterone and androgen in the body.

References

  1. Cho, Y. H., Lee, S. Y., Jeong, D. W., & Choi, E. J. (2014). Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-based complementary and alternative medicine 2014.
  2. Semalty, M., Semalty, A., Joshi, G. P., & Rawat, M. (2011). Hair growth and rejuvenation: an overview. Journal of Dermatological Treatment, 22(3), 123-132.

How to Make Your Hair Grow: The Ultimate Guide

Superfast hair growth guide

I’m the author of 4 books about hair loss. I’ve been researching hair growth for over ten years. What I don’t know about making your hair grow, isn’t worth knowing.

There are tonnes of myths on the internet. Butre what I’m about to show you, really works. Just follow my instructions precisely and your hair will grow faster, get much healthier and may even get thicker.

Step 1: Give Your Hair Ultimate Nutrition

Increase nutrient supply to hair

Cysteine is considered to be one of the main factors involved in hair growth

Your hair is made of a protein called keratin. Keratin is made of amino acids and sulphur. The biggest component of your hair is an amino acid called cysteine. Several studies have revealed that certain amino acids cause your hair to grow faster. The most important ones are cysteine, lysine and taurine.

Supplementing your diet with these amino acids has shown increased hair growth and improved hair health in several studies.

Cysteine: the key to mega hair growth?


Recent studies have suggested that a diet poor in cysteine or various health problems causing malabsorption of cysteine might be one the causes of hair loss.

Biotin Silica cysteine supplement for hair growth

It’s worth noting that a lack of cysteine causes hair loss and on the other hand, high levels of cysteine seem to help make hair grow faster. It might be the case that you lack cysteine, which has resulting in your hair growing more slowly than you want.

Buy cysteine on Amazon.

Why do so many Far Eastern women have really great hair?

Asian woman long hair

fewer cases of male pattern baldness in Asians might be due to their diet being rich in L-Lysine

Studies have shown that the amino acid lysine has a direct impact on hair growth and guess what… Asian diets are rich in lysine.

Here’s an extract from my research on lysine:

Studies on animals showed that lysine may be the key to better hair. Wool follicles and fibres of pre-ruminant lambs that were fed a diet containing little lysine experienced abnormalities such as: incomplete keratinisation, distortion of fibres and partial degradation in the distal parts of the follicles. When the animals were returned on a diet rich in lysine, their hair structure improved rapidly, but abnormalities were still observed in older fibres. (Chapman et al., 1983)

What does this mean? It means:

  1. People with a diet high in lysine are likely to have healthier hair that grows faster
  2. People with a diet low in lysine are likely to have unhealthy hair that grows poorly

The answer? Eat foods rich in lysine:

Organic beef food high in iron

  • Meat
  • Fish like salmon and tuna and Seafood like shrimp
  • Soya foods like tofu and soy beans
  • Seeds and nuts
  • Eggs
  • Beans
  • See here for a list of foods with lysine quantities.

    Buy lysine on Amazon.

    Soy and chili peppers

    Soy Isoflavones

    Studies show there is also a connection between ‘soy isoflavones’ and capsaicin (the chemical that gives peppers their heat). A diet rich in soy isoflavones and capsaicin is thought to increase the amount of ‘equol’ produced in the body. Equol is apparently what makes Far Eastern people look youthful in their old age.

    It also appears that the combination of soy isoflavones, capsaicin and green tea may have a powerful protective effect on hair, preventing hair loss. This may explain why hair loss rates are much lower in regions of the Far East where the people still eat traditional dishes and drink green tea.
    Buy soy isoflavones on Amazon.

    Taurine: turbo charge your hair growth

    The observations concluded that taurine protects the hair follicle from the effects of (TGF)-β1 as well as promoting hair survival

    You may be familiar with taurine. It’s an ingredient in Red Bull energy drinks — probably the only ingredient that’s good for you! And it’s really good for you.

    Another study on taurine supplementation in the treatment of women with hair fragility shows the potential benefits of a systematic taurine supplementation; the study was conducted on 20 women with ages between 20 to 68 years who had fine hair and decreased hair thickness and shows that daily oral intake of taurine 150mg, Catechin 75mg and Zinc 15mg is beneficial to hair health. 11/12 women showed increased hair diameter from 0,040 to 0,045 μm while 6 other women showed an increase from 0,040 to 0,043 μm. (Tosti et al., 2007)

    Take these three supplements daily with your three meals. Taurine with breakfast, lysine with lunch and cysteine with dinner.

    By increasing your intake of these amino acids you may have a direct impact on your hair growth. However your hair also needs many other nutrients in order to grow, including biotin and iron. An iron deficiency is one of the more common causes of hair loss in women and may be the reason your hair isn’t growing as fast as you want it to.

    To get all the nutrients your hair needs to grow healthy and strong, try to eat green salad leaves like spinach, kale, rocket, watercress and so on every day. An easy way to do this is to put a bag of baby leaf greens into a blender with some water and some strawberries for flavor and drink two glasses a day.

    Make your hair grow faster

    The easiest way to maximize nutrition for your hair is to drink a special hair growth smoothie I developed, which you can make at home. To learn about my powerful hair growth smoothie check out my NKI Method for boosting hair growth.

    Ultimate foods for hair growth

    Organic beef food high in iron

    B vitamins and protein are the best foods for feeding your hair and the richest sources of these nutrients are meat and fish — particularly shell fish.

    Try to include foods from this list of the 15 best foods for hair growth in your diet every week.

    Step 2: Give Your Hair Ultimate Protection

    The key to shiny hair is having unbroken hair. As soon as your hair breaks it will not shine, because that shine is created by the hair having a flat surface

    If your hair breaks and splits you have to get it trimmed to keep it looking nice. However, this means you can’t grow your hair as long as you want it. So you need to prevent your hair from breaking. This is easy. Again science comes to the rescue.

    As I said, hair is made of protein. When it get’s damaged, bits of protein are broken away from the hair. This prevents your hair from looking shiny. The key to shiny hair is having unbroken hair. As soon as your hair breaks it will not shine, because that shine is created by the hair having a flat surface. When it breaks, little bits of keratin break away making the surface rough, so it doesn’t reflect light.

    If your hair is dry and brittle you need to go to extreme lengths to protect it. Step 1 (above) is the best thing you can do because it makes your hair stronger from within and therefore more resilient to breaking. However, in the meantime, we need to protect your hair to prevent breakage until the amino acids start to take effect.

    Take these steps:

    1. Never brush your hair when it’s wet (water makes your hair more fragile)
    2. Towel dry your hair gently by smoothing the towel over your hair to rub off moisture, then leave it to dry naturally. If you want to use a hairdryer, make sure you put a strong hair protection cream on first
    3. Only suse straighteners if you’ve applied a very good pre-straightening treatment.
    4. Only ever tie your hair up loosley. Tightly pulling on your hair can cause traction alopecia, which is the last thing you want. It also stretches the hair, making it more fragile, therefore more succeptable to breakage.
    5. If you can avoid it, don’t wear tight hats or other head gear. Again, this makes the hair more fragile.

    How to get superfast hair growth

    Use these video tutorials to make your hair grow as fast as possible. These are all created by people who have used the techniques being explained.

    The inversion method

    Make your hair grow faster with the inversion method

    Increase blood flow to your scalp so that more nutrients flow to your hair, feeding it and accellerating hair growth.

    Indian secrets to long hair

    Indian secrets to growing long hair

    Why are Indian women able to grow their hair so long? What is it they do that keeps their hair so healthy? Watch this video to learn the Indian secret to growing long hair.

    2 ingredient hair mask

    Hair mask to protect hair and help it grow

    Use this simple 2 ingredient hair mask to protect your hair so it can grow longer without breaking.

    The 2 minute method

    Reactivate dormant hair follicles

    The best kept secret in the hair loss industry. Learn how this remarkable 2 minute method encourages hair to grow faster, thicker and longer.

7 Natural Dry Shampoo Alternatives: That Nourish Your Hair & Scalp

You may have heard the news all over the internet a few months back about dry shampoo being bad for your hair. Well that’s not going to stop people using dry shampoo, but if you really have to use it, make sure you use one of these healthier versions, based on nourishing natural ingredients that will actually feed your hair and keep youtr scalp healthy.

Why should you switch to one of these natural dry shampoos?

You may have heard the news last year that dry shampoo may be bad for your hair and may even cause hair loss. I also blogged about this here on nicehair.org several years before the news broke.

If you use dry shampoo a lot like so many women do, give one of these products a try. You might find they make your hair look nicer than your usual dry shampoo. Several of them also contain ingredients that are believd to promote hair growth, including rosemary and silica.

If you’ve given any of these natural alternatives to dry shampoo a try let us know what they were like by leaving a comment below. And if you have a recommendation for a product that’s not included here let me know by pasting a link to it in a comment.

Home remedies for hair loss, that you probably have around the house

Whether you are trying to combat hair loss naturally or you simply want to try some home remedies before seeing what’s available, the following treatments should be easy to find around the house and have been scientifically proven to help with hair loss.

Garlic

Garlic

Garlic has been researched as a treatment for hair loss and one study found it to show quite the significant response (95%) when compared to the placebo group. The study used a garlic gel which should be available in most health stores but you can also use garlic oil instead. (Hajheydari et al., 2007)

Green Tea

Organic green tea

Drinking green tea has a lot of benefits and it also seems to improve the quality of hair and have the potential to stimulate hair regrowth. A study on mice showed great hair regrowth in the group that was fed green tea for 6 months when compared with the control group. (Estafandiari and Kelly, 2005) It is unknown whether this is due to the tea’s effects on the circulatory system or its anti-inflammatory properties.

Peppermint

Orgasnic peppermint oil

Peppermint Oil has been studied as a topical treatment for hair loss and using 3% Peppermint Oil topically stimulates hair growth and could stop hair fall in a very short time. Peppermint Oil works by promoting the vascularization of the hair dermal papilla. (Park et al., 2014)

Pumpkin seed oil

Pumpkin seed oil

Pumpkin seed oil is another home remedy that might solve your hair loss problem. A study showed an increase in hair growth by 40% in men who were treated with pumpkin seed oil for 24 months with no adverse effects. (Young et al., 2014) This may be due to its potential to inhibit 5-alpha-reductase when taken as an oral supplement in the form of capsules.

Hibiscus

Hibiscus oil

Hibiscus applied topically may also have the potential to help with hair loss and promoting hair regrowth. A study on rats suggested that the extract of hibiscus leaves had a positive effect on the hair growth phase, but the mechanism behind it is unknown. (Adhirajan et al., 2003) To use this remedy at home you will need either hibiscus rosa extract, oil or gel which should be applied topically on the scalp.

  1. Oh, J. Y., Park, M. A., & Kim, Y. C. (2014). Peppermint Oil Promotes Hair Growth without Toxic Signs. Toxicological Research, 30(4), 297–304. http://doi.org/10.5487/TR.2014.30.4.297
  2. Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R. Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: A double-blind randomized controlled study. Indian J Dermatol Venereol Leprol [serial online] 2007 [cited 2017 Mar 1];73:29-32. Available from: http://www.ijdvl.com/text.asp?2007/73/1/29/30648
  3. Esfandiari, A., & Kelly, A. P. (2005). The effects of tea polyphenolic compounds on hair loss among rodents. Journal of the National Medical Association, 97(8), 1165–1169.
  4. Cho, Y. H., Lee, S. Y., Jeong, D. W., Choi, E. J., Kim, Y. J., Lee, J. G., … Cha, H. S. (2014). Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial.Evidence-Based Complementary and Alternative Medicine : eCAM, 2014, 549721. http://doi.org/10.1155/2014/549721
  5. N Adhirajan, T Ravi Kumar, N Shanmugasundaram, Mary Babu, In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn., Journal of Ethnopharmacology, Volume 88, Issues 2–3, October 2003, Pages 235-239, ISSN 0378-8741, http://dx.doi.org/10.1016/S0378-8741(03)00231-9.
    http://www.sciencedirect.com/science/article/pii/S0378874103002319

The Best Home Remedies for Hair Loss: Based on Credible Research

When it comes to home hair loss remedies, not many of them live up the expectations, let alone show any results whatsoever. There is a plethora of scientifically proven home remedies but the following are those that yield the most significant results as well as nourishing the hair follicle for healthier hair.

The best home remedy for hair loss

There are a few key ingredients that you can use at home to make a powerful hair growth tonic. By massaging these ingredients into your scalp you will promote hair regrowth in several ways, which I’ll explain below:

Castor Oil to increase hair growth

Organic castor oil

Castor oil is a natural plant oil with a very high concentration of something called ricinoleic acid. This is the key to its hair growth benefits. Ricinoleic acid has been shown in studies to increase PGE2 in the scalp. PGE2 has been shown to increase hair growth and balding scalps contain lower levels of PGE2.

So, by applying castor oil to the scalp we can increase PGE2 in the scalp and thereby increase hair growth.

Coconut Milk to prevent breakage

Applying a mask made with coconut milk can help lubricate the hair and prevent hair breakage. Coconut milk will also reduce the protein loss from hair when is used as a prewash or postwash a grooming product. This is due to the lauric acid in coconut oil which can penetrate into the hair shaft immediately and nourish the hair for a quick fix. (Lima et al., 2015)

Onion Juice

Onion

A quick home remedy that has been around for ages is to use onion juice on your scalp before going to bed. A study was done on two groups of people who used onion juice and tap water topically on their scalp in order to see the differences between the two. The researchers discovered significant differences between the two groups after only 2 weeks. (Sharquie and Al Obaidi, 2002)

Honey

Organic manuka honey

If your hair loss is caused by seborrheic dermatitis or excessive dandruff and inflammation of the scalp, a quick proven home remedy is a honey mask. In a 2001 study, a mask was made with warm water in which honey was added; the mixture was rubbed into the scalp and kept for 3 hours before rinsing. In just a week the participants saw noticeable changes including: wound healing, improvement in hair texture, less hair loss and less dandruff and inflammation. (Waili, 2001)

Have you used a home remedy?

The internet seems to be filled to the brim with home remedies for hair loss. But have you heard of one or even used one that’s shown significant hair regrowth results? Let us know in the comments.

  1. Lima, E. B. C., Sousa, C. N. S., Meneses, L. N., Ximenes, N. C., Santos, M. A., Vasconcelos, G. S., … Vasconcelos, S. M. M. (2015). Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review. Brazilian Journal of Medical and Biological Research, 48(11), 953–964. http://doi.org/10.1590/1414-431X20154773 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671521/
  2. Sharquie, K. E. and Al-Obaidi, H. K. (2002), Onion Juice (Allium cepa L.), A New Topical Treatment for Alopecia Areata. The Journal of Dermatology, 29: 343–346. doi:10.1111/j.1346-8138.2002.tb00277.x
  3. Al-Waili NS. Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff. Eur J Med Res. 2001;6:306–8. [PubMed]

What converts testosterone to DHT?

The main androgen hormone secreted in the body is testosterone but in order to be carried to tissue such as that in the brain or the skin, testosterone bonds with the enzyme 5-alpha reductase and produces DHT.

stress is linked to hair loss is because stress causes the release of cortisol hormone, which increases adrenaline, testosterone and DHT

DHT is responsible for male characteristics such as increased muscle mass and a deep voice and during fetal development it plays a role in the development of the penis and prostate. In normal levels, DHT regulates hair growth. If there is increased 5-alpha reductase in the body, the amount of testosterone converted into DHT will increase, which may lead to hair loss. This may be because increased levels cause an acceleration of the life cycle of the hair and increase in the hairs resting phase — this gradually shrinks the hair follicle by reducing blood circulation so the hair follicle is not properly nourished in order to survive.

DHT also seems to trigger an autoimmune response in the body that destroys the hair follicle. Most treatments for hair loss include blocking the conversion (e.g. finasteride) of testosterone to DHT in order to delay the progression of alopecia. (Ustuner, 2013)

DHT can be influenced by both external and internal factors. For example, the idea that stress is linked to hair loss is because stress causes the release of cortisol hormone, which increases adrenaline, testosterone and DHT. Endocrine issues such as an underactive thyroid can also influence hormone levels and lead to hair loss. People with an enlarged prostate will also show increased DHT levels and there’s even a theory (Bhargava, 2014) that the mechanism behind male pattern baldness is the body’s way to protect men from prostate cancer.

  1. Ustuner, E. T. (2013). Cause of Androgenic Alopecia: Crux of the Matter. Plastic and Reconstructive Surgery Global Open, 1(7), e64. http://doi.org/10.1097/GOX.0000000000000005
  2. Bhargava, Shiva, Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer, Medical Hypotheses , Volume 82 , Issue 4 , 428 – 432

Redensyl for Hair Loss: Is This The Next Big Thing?

iRestore redensyl hair growth serum

Redensyl may become a big player in the fight against hair loss, due to its regenerative active ingredients and its potential to yield satisfactory results within a short timeframe.

Redensyl targets the hair follicle stem cells in order to stimulate them. Its promponents claim it’s much more powerful than any other topical solution available.

How does Redensyl promote hair growth?

85% of the people participating in the project saw significant hair growth in under 3 months

Redensyl is made from molecules that target the outer root sheath cells (ORSc) and the hair follicle dermal papilla cells (HFDPc) at the same time.

ORSc are the hair follicle stem cells located in the bulge along the hair. These stem cells have certain characteristics: they are not as productive as other stem cells and not as adapted to improve the quality of the keratinocytes in order to maintain hair growth in the follicle.

The HFDPc are the fibroblasts located in the dermal papilla and people who experience hair loss also experience less efficient fibroblasts, which leads to a defective initiation of the anagen phase.

A hair follicle stem cell health booster

Another test based on self-evaluation showed that Redensyl 3% reduced hair loss, increased the strength and thickness of the hair and improved the capillary density in just three months of treatment adding +10,200 hairs on average

Redensyl products contain DHQG or dihydroquercetin-glucoside, a polyphenol that acts upon the stem cells located in the hair follicle. DHQG maintains their differentiation while helping them divide and protects them from cell death while initiating the anagen cycle. Furthermore DHQG has the characteristic of boosting the metabolism of the dermal papilla fibroblasts.

An anti-inflammatory

Redensyl contains EGCG-glucoside, which seems to reduce inflammation that often occurs in the scalps of people suffering hair loss.

Studies by Induchem

When comparing the Minoxidil 1% with Redensyl 1% the results showed twice as much hair growth with Redensyl

Induchem, a company producing Redensyl, conducted several studies to test its efficacy. In one study, human fibroblast dermal papilla cells were incubated for 48 hours and treated with dihydroquercetin-­glucoside (DHQG), a modified form of polyphenol. When evaluated, the results showed that DHQG helps “activate the division of ORCs“.

Another study was conducted for EGCG-glucoside and showed that the product has an anti-irritation potential. This is important because irritated scalps are more prone to hair loss and some of the most effective topical anti-hair-loss products have scalp irritation as a major side effect.

Remarkable results on androgenetic alopecia

Redensyl was also studied on volunteers that were suffering from androgenetic alopecia and the results were quite remarkable. One surprise was the product works really fast: 85% of the people participating in the project saw significant hair growth in under 3 months. The results showed that new hair follicles increased by 9% while there was a 17% decrease of hair loss.

Another test based on self-evaluation showed that Redensyl 3% reduced hair loss, increased the strength and thickness of the hair and improved the capillary density in just three months of treatment adding +10,200 hairs on average. The volunteers declared that they were satisfied by the product and they would buy it (71%).

Redensyl vs Minoxidil

Another test that compared Redensyl 1% with Minoxidil 1% was conducted to evaluate the product’s potential on hair follicle growth. The product was tested on hair obtained from 4 male donors; after 7 and 10 days the hair growth increase was measured and the results showed 214% more hair growth compared with the control group. When comparing the Minoxidil 1% with Redensyl 1% the results showed twice as much hair growth with Redensyl.

Where can I get some Redensyl?!!!

The results show that the patients had an increase of 10.9% of hair when compared with their first visit

Redensyl is available to order online as part of the Redenhair treatment which contains a combination of elements, regenerating shampoos, oral supplements and the topical solution containing Redensyl. The Redenhair treatment has been clinically tested. The study was done to test the efficacy of Redenhair on 30 male participants suffering from alopecia 1 to 3 vertex.

The participants applied 2 pipets a day of topical solution and massaged their scalp. They also took 2 capsules/day of the oral supplement included in the Redenhair treatment. The results show that the patients had an increase of 10.9% of hair when compared with their first visit. They also had a decrease of the telogen phase of 10.9% at the end of the 3rd month of treatment.

Visually, the hair volume was improved gradually during the three months as follows: 10% more volume after the first month, 46.7% more volume after the second month and 66.7% more volume after the third month. The self-assessment questionaries’ showed that 80% of the participants considered the experience to be a positive one, considering it to be an easy to follow routine and an adequate treatment for hair loss, preferring it to their normal routine.

The patients also declared in the self-assessment questionnaires that they noticed a significant reduction in their hair loss, felt that their hair root was reinforced and the hair follicle had more strength, and they felt their hair was healthier.

To further attest its efficacy, The Innovation Zone Best Ingredient Award gave Redensyl the Silver Prize for not only creating a green product but also one with demonstrable results. The self-assessment tests and the results of the studies done on human patients show that Redensyl is not just an efficient hair loss treatment but also one with an easy routine to follow.

Buy Redensyl topical hair loss serum online

You can already buy this treatment quite cheaply on Amazon. Here are some of the most notable products:

  • Strong-Hairpro redensyl hair loss serum
  • iRestore redensyl hair growth serum
  • Burst organic topical redensyl hair loss treatment

References and further reading

  1. http://truactivs.com/wp-content/uploads/2015/07/REDENSYL.pdf
  2. http://www.nardev.com/UploadSection/ProdCat-276-1446515551.pdf
  3. https://www.redenhair.com/en/content/15-redensyl
  4. http://www.redenhair.com/img/cms/redenhair.pdf
  5. http://www.induchem.com/news-home/redensyl-silver-award-at-in-cosmetics-2014/

JAK Inhibitors for Hair Loss: A Breakthrough Cure?

Tofacitinib JAK inhibitor for hair loss

JAK inhibitors, also known as Janus kinase inhibitors or jakinibs are medication developed to stop or decrease the activity of one or several of the Janus kinase family of enzymes. These inhibitors are mainly used to treat a number of conditions that range from inflammatory disease like rheumatoid arthritis to autoimmune diseases and even cancer.

Throughout the testing process, JAK inhibitors have also been effective in treating cases of alopecia areata as well as other types of alopecia. Further studies suggest that JAK inhibitors show huge potential for reversing hair loss, with some medical specialists considering them the “holy grail” of potential treatments. But before delving more into how JAK inhibitors may cure hair loss, let’s take a closer look at how they work.

How they work

researchers have observed that JAK inhibitors played a role in kick-starting enzymes in hair follicles that block hair in the dormant state of growth

JAK enzymes have numerous functions in the body, one of which has to do with the hair growth cycle. JAK inhibitors suppress the function of JAK enzymes, helping with inflammation down to cell level and providing a potential solution for hair loss. JAK inhibitors have been developed as a solution for conditions such as rheumatoid arthritis but have also been used to aid or treat other inflammatory conditions. During trials for rheumatoid arthritis medication, researchers have observed that JAK inhibitors played a role in kick-starting enzymes in hair follicles that block hair in the dormant state of growth. (Shreberk-Hassidim R et al., 2017)

JAK Inhibitors for hair loss

The results were extremely promising with nine out of the twelve patients showing a whopping 92% hair regrowth by the end of the treatment

JAK inhibitors have shown the most promise when it comes to addressing alopecia areata, which is a significant step in the right direction as there is no FDA-approved treatment for the condition. The two drugs that hold most promise in providing relief are ruxolitinib and tofacitinib.

Ruxolitinib

A University of Columbia study (Mackay-Wiggan J. et al, 2016) looked into the effects of the oral JAK1/2 inhibitor ruxolitinib on 12 patients who suffered from moderate to severe cases of alopecia areata. Researchers administered 20mg of the substance, twice per day for a period of 3 to 6 months with an extra 3 months treatment with a follow-up off drug. The results were extremely promising with nine out of the twelve patients showing a whopping 92% hair regrowth by the end of the treatment. While the study’s results were overwhelmingly positive with basically no side-effects, larger, randomized studies are required to precisely determine the efficiency of ruxolitinib in treating alopecia areata.

Tofacitinib

Of the total 66 participants in the study, 32% experienced 50% or greater improvement in hair regrowth

Tofacitinib is another potential drug that aims to treat alopecia areata by using the pan-JAK inhibitor, tofacitinib citrate. A 2-center, open label, single arm trial was carried out by a team of researchers from universities such as Yale, Columbia and Stanford. The study used Tofacitinib 5mg which was administered twice a day for 3 months. Of the total 66 participants in the study, 32% experienced 50% or greater improvement in hair regrowth. The downside of the results showed that while the treatment was efficient, after drug cessation, the disease relapsed in under 9 weeks. Side-effects were minor and consisted of grade I and II infections in a few patients. While the drug was deemed safe and effective, the lack of a durable cure requires further development and testing. (Kennedy Crispin M et al., 2016)

Alopecia universalis is another condition where JAK inhibitors have shown promising results. Alopecia universalis is a rare but devastating condition, an aggravated form of alopecia areata that leads to total loss of hair on the scalp and body. (Islam N et al., 2015)

A Yale medical trial conducted by Dr. Brett A. King et al.(2014) found that Tofacitinib administered at a rate of 10mg per day completely reversed a case of alopecia universalis. The patient saw progress by the two month mark, with visible scalp and facial hair regrowth. A further three months therapy where the Tofacitinib dosage was increased to 15mg per day resulted in completely regrown scalp hair and visible eyebrows. By the end of the study at the eight month mark, the patient had completely recovered his scalp and bodily hair. The immensely promising results led Dr. Brett A. King to propose a clinical trial involving a tofacitinib topical solution.

JAK Inhibitors for Androgenic Alopecia (the most common form of hair loss)

some studies suggest that there might be untapped potential for JAK inhibitors

While alopecia areata and its more severe forms of alopecia universalis and alopecia totalis were in desperate need of a thoroughly tested and approved treatment, they constitute only a small percentage of all hair loss cases with androgenetic alopecia, also known as male pattern baldness, constituting the vast majority of cases.

When it comes to providing a solution to androgenetic alopecia, JAK inhibitors aren’t nearly as promising as their effects on alopecia areata.

Despite little known positive feedback when it comes to dealing with male pattern baldness, some studies suggest that there might be untapped potential for JAK inhibitors. In a study conducted on mice by Angela M. Christiano, one of the most ardent supporters of a JAK inhibitor solution for androgenetic alopecia, the inhibition of JAK-STAT signalling promoted hair growth. The study’s goal was to show the positive results of inhibition of JAK-STAT signalling for sufferers of alopecia areata. While results were satisfactory, the data also showed that the topical treatment of skin, both human as well as rodent, with small-molecule inhibitors of JAK-STAT resulted in the onset of anagen phase and subsequent hair growth cycle steps. During the study, Dr. Christiano and her team showed that JAK inhibition regulates the activation of key hair follicle populations while improving the inductivity of dermal papilla cells. (Christiano et al., 2015)

The promising results as well as Dr. Christiano’s research have led to Aclaris Therapeutics Inc. licensing a patent portfolio from Columbia University that aim to develop methods of using JAK inhibitors for the treatment of alopecia areata and adrogenetic alopecia as well as other dermatological conditions.

The portfolio is also made up of a U.S. patent which aims to develop methods of treating alopecia areata and androgentic alopecia as well as other hair loss disorders by administering ruxolitinib. Also included is a recently issued patent in Japan which is directed to pharmacetutical compositions made up of ruxolitinib, baricitinib as well as other JAK inhibitors with the goal of providing a treatment for androgenetic alopecia, alopecia areata and other hair loss disorders.

While research on JAK inhibitors as a solution for hair loss is still in its infancy, most studies suggest there is huge untapped potential. JAK inhibitors will most likely become one of the best ways to treat alopecia areata in the immediate future. Their role in the treatment of androgenetic alopecia is still being looked into, however, with numerous studies still being conducted and a topical solution being presently developed there is a good chance that they will play at least a role as an anti-inflammatory addition in hair loss treatment.

  1. Janus kinase inhibitors in dermatology: A systematic review 
    Shreberk-Hassidim R., Ramot Y., Zlotogorski A. (2016)  Journal of the American Academy of Dermatology, https://www.ncbi.nlm.nih.gov/pubmed/28169015
  2. Kennedy Crispin, M., Ko, J. M., Craiglow, B. G., Li, S., Shankar, G., Urban, J. R., … King, B. A. (2016). Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight, 1(15), e89776. https://www.ncbi.nlm.nih.gov/pubmed/27699252
  3. Kennedy Crispin, M., Ko, J. M., Craiglow, B. G., Li, S., Shankar, G., Urban, J. R., … King, B. A. (2016). Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight, 1(15), e89776. http://doi.org/10.1172/jci.insight.89776
  4. The autoimmune basis of alopecia areata: A comprehensive review
    Autoimmunity Reviews, Volume 14, Issue 2, Pages 81-89
  5. Naseeha Islam, Patrick S.C. Leung, Arthur C. Huntley, M. Eric Gershwin https://www.ncbi.nlm.nih.gov/pubmed/25315746
  6. Killing two birds with one stone: Oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis 
    Craiglow B.G., King B.A.  (2014)  Journal of Investigative Dermatology,  134  (12) , pp. 2988-2990. https://www.ncbi.nlm.nih.gov/pubmed/24940651
  7. Harel, S., Higgins, C. A., Cerise, J. E., Dai, Z., Chen, J. C., Clynes, R., & Christiano, A. M. (2015). Pharmacologic inhibition of JAK-STAT signaling promotes hair growth. Science Advances, 1(9), e1500973. http://doi.org/10.1126/sciadv.1500973 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646834/

How to stop hair fall and grow new hair

Although there are numerous hair loss treatments out there most fall short when it comes to results. ‘The Big 3’ still remain the only proven treatments to stop hair fall and also stimulate the growth of new hair: Prescription Finasteride, high strength Minoxidil and low strength topical Ketoconazole.

Minoxidil and Finasteride

Best topical hair loss treatments

The combination between Minoxidil and Finasteride seems to be the most successful treatment for hair fall. Multiple studies have shown that Finasteride treatment is superior to minoxidil but a combination between the two is the best chance of stopping hair fall and obtaining new hair growth. (Hu et al., 2015)(Arca et al., 2004)

To see the best topical minoxidil products you can buy online, see this article.

Dermaroller

Dermaroller for hair loss

Another approach that seems to have shown great results, especially when it comes to the complicated issue of hair regrowth is the treatment that combines both minoxidil and the Dermaroller. A dermaroller is a micro-needling tool used in cosmetic treatments to improve the look of scars, wrinkles and stretch marks. Scientists believe that wounding may induce the activation of growth factors by stimulating the derma papilla associated stem cells. In association with minoxidil, which stops hair fall, the Dermaroller helps grow new hair.

Dutasteride

Dustasteride has been shown to have superior effects on hair growth when compared with Finasteride. The product is a type 1 and type 2 5-alpha-reductase inhibitor while Finasteride is just a type 2 5-alpha-reductase inhibitor, which may explain its hair regrowth potential. (Shanshanwal and Dhurat, 2017)

RU58841

ru58841-topical-anti-androgen-for-hair-loss

While studying RU58841 effects on hair loss scientists discovered that topical application could help hair grow faster, thicker and as well as significant hair regrowth in bald areas. (Huei et al., 1998)(Brouwer et al., 1997) Its effects are due to its powerful anti-androgenic potential and the fact that it can be applied topically eliminates most side effects anti-androgens have when taken orally. This too can be applied together with minoxidil in order to improve its results.

Unfortunately RU58841 is a fairly long way off being approved for use as a hair loss treatment. In fact the only way to buy it at the moment is as lab chemical and it’s very expensive. Side effects have not yet been established with medium or long-term use.

A new breakthrough natural hair growth method

Alain Pamintuan before and after hair loss nicehair

Until now all hair loss treatments, with the exception of hair transplantation surgery, have shown quite mediocre results. Even the above treatments, which are considered the most effective in the world by most, achieve barely any noticeable results for many users.

However, there is a new hair regrowth method, called the Hormone Fix, which to date has shown results that seem to outperform all other treatments. The Hormone Fix is a method based on the use of topical IGF-1, antioxidants, anti-inflammatories, the Dermaroller and a special method that triggers dormant hair follicles to reactivate.

To learn more about the Hormone Fix, see the results and how it works here.

References and further reading

  1. Hu, R., Xu, F., Sheng, Y., Qi, S., Han, Y., Miao, Y., Rui, W. and Yang, Q. (2015), Combined treatment with oral finasteride and topical minoxidil in male androgenetic alopecia: a randomized and comparative study in Chinese patients. Dermatologic Therapy, 28: 303–308. doi:10.1111/dth.12246
    https://www.researchgate.net/profile/Osman_Koese/publication/8395671_An_Open_Randomized_Comparative_Study_of_Oral_Finasteride_and_5_Topical_Minoxidil_in_Male_Androgenetic_Alopecia/links/542a60580cf27e39fa8e8554.pdf
  2. Dhurat, R., Sukesh, M., Avhad, G., Dandale, A., Pal, A., & Pund, P. (2013). A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study. International Journal of Trichology, 5(1), 6–11. http://doi.org/10.4103/0974-7753.114700
  3. Shanshanwal SJ, Dhurat RS. Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study. Indian J Dermatol Venereol Leprol [serial online] 2017 [cited 2017 Mar 1];83:47-54. Available from: http://www.ijdvl.com/text.asp?2017/83/1/47/188652
    http://www.ru58841.info/ru58841-the-science/

How to make your hair thicker Instantly

Use a leave-in thickening serum to increase the thickness of individual hairs

Here’s a nice surprise for you: These things actually work! Wash your hair as normal. Let it dry as much as possible. The dryer the better. Apply the serum sparingly all over your hair. These are the three best ones I’ve used. Most others don’t seem to do a lot (even the expensive ones) but these three work wonders:

Use a thickening cream to style your hair

If you have short hair and you want to style it with a gel, creme or wax there are some really good products that volumize hair while providing hold. Unfortunately some of them seem to be fairly useless, but of the ones I’ve tested the three below are really good:

Decaesare Thicken Creme

Thicken volumizing cream

If you haven’t tried the Decaesare Thicken products yet I recommend you do. I’ve tested hundreds of these thickening creams and this in my opinion is the best for increasing the volume of hair. It seems to somehow plump up the hair making it thicker and easier to style in a way that looks more volumized.

It’s quite a thick cream that feels nice. It’s not like some creams that are a bit watery. Of all the ones I’ve tested, this is the one I’d go for.

Energizer Hair Thickening Serum

Although Decaesare Thicken is the most effective volumizing treatment I’ve tried the only problem is it contains no ingredients that promote hair growth. So you might want to try a volumizing product that also contains ingredients that promote hair growth and/or prevent hair loss, like the one pictured.

I’ve created a list of what I think are the best volumizing hair products that also contain ingredients that promote hair growth here.

OK, so we’ve got the immediate problem sorted by instantly volumizing your hair with a thickening product. Now though we need to try to reactivate dormant hairs in your scalp to make your hair genuinely thicker…

Proven ways to increase hair growth

These are scientifically proven natural methods to make your hair thicker and fuller that can be used in combination with other natural hair loss treatments.

1. The Hormone Fix

Stuart Bridgeman before and after hair loss nicehair.org

My number one recommendation for naturally thickening your hair is to follow the Hormone Fix — it’s a powerful natural method that stimulates hair growth. It takes just two minutes per day to perform and the results from users of the method are remarkable. If it can get results like the ones pictured for people with hair loss, imagine how effective it will be at volumizing your hair if you’re not experiencing hair loss.

Find out more about the method here.

2. Feed your hair from within

Hair is made of a protein called keratin. Keratin is produced in the scalp by combining several key amino acids. Your body needs several key supporting nutrients to produce hair keratin. These include biotin, iron and fatty acids. Biotin is particularly important:

Biotin is used by the body to break down proteins you consume through diet into the amino acids needed to form keratin.

Best hair loss supplements

Your hair receives all the nutrients it needs to grow via the bloodstream. So the best way to feed your hair is to eat foods that make your hair grow. If you find it difficult to eat lots of those types of foods, use a hair growth supplement. It’s possible that stress or a hormonal imbalance is causing your hair to receive an inadequate supply of nutrients. In this instance, ‘supplementing’ your diet is exactly what is required to compensate for the deficiency your hair is experiencing.

See my personal reviews of the best products below:

It could be something as simple as a minor iron deficiency, which is causing your hair to not grow as much as you’d like it too. Iron deficiency is a common cause of thinning hair among women.

3. Use a laser comb three times per week

Chromosphores

Although laser combs are unlikely to regrow your hair if you’re bald, the technology used in them does show promise for making hair grow faster and potentially fuller.

How lasers jumpstart hair follicles by activating ‘chromophores’:

Chromophores are substances in your cells that are very sensitive to light. “Chromophore” literally means “color-loving”, as the pigmented substances in our cells such as amino acids, hemoglobin and melanin tend to absorb energy from light sources. Once they are activated by light, chromophores signal and trigger various cellular processes. Lasers are intense enough to penetrate deep into the scalp and reach the follicles (without heating up the tissue), activating the chromophores in these cells.

Best laser combs

Laser combs are much cheaper than they used to be. And all you have to do is sit down and hold the comb on your scalp for 15 minutes, three times a week, which is actually quite relaxing.

If you want to increase the volume of your hair I recommend using a laser comb. View my review of the world’s best laser combs for hair growth to find a suitable product.

4. Scalp Massages

A scalp massage is not just a way to relax but also a way to improve the health of the hair follicle without any side effects. A study on Japanese males showed that only 4 minutes of scalp massage per day can improve total hair count, hair thickness and hair growth rate. One explanation for the results is that mechanical stress is transmitted to human dermal papilla tissue. (Koyama et al.,2017)

5. Hypericum extract

Hypericum extract is another way to obtain thicker and fuller hair naturally. A study in 2016 showed that the t-Flavanone synthesized from the plant doesn’t just actively stimulated hair growth but also increases the strength of the hair follicle and reinforces the hair root by increasing blood circulation. (Nagasawa et al., 2016)

A natural oral supplement called Viviscal may be the key to fuller hair. The supplement is made from a marine complex called AminoMarC, a form of silica extracted from Equisetum sp., Vitamin C, apple extract powder, L-cystine and L-methionine. A study researching this natural supplement showed that the group receiving the treatment had an increase in the number of hairs as well as an enhancement in hair diameter. (Ablon and Dayan, 2015)

6. Rosemary oil

Rosemary oil

When it comes to natural alternatives to minoxidil, Rosemary Oil seems to be the answer. One study (Panahi et al.,2015) found no significant difference between the results on hair loss in a group treated with minoxidil and another group treated with Rosemary Oil. This article cites other studies that have confirmed the positive effects Rosemary Oil treatment.

  1. Koyama, T., Kobayashi, K., Hama, T., Murakami, K., & Ogawa, R. (2016). Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue. Eplasty,16, e8.
  2. Nagasawa, A., Wakisaka, E., Kidena, H., Nomura, T., Hotta, M., Taguchi, H., & Moriwaki, S. (2016). t-Flavanone Improves the Male Pattern of Hair Loss by Enhancing Hair-Anchoring Strength: A Randomized, Double-Blind, Placebo-Controlled Study. Dermatology and Therapy, 6(1), 59–68. http://doi.org/10.1007/s13555-016-0101-1
  3. Ablon, G., & Dayan, S. (2015). A Randomized, Double-blind, Placebo-controlled, Multi-center, Extension Trial Evaluating the Efficacy of a New Oral Supplement in Women with Self-perceived Thinning Hair. The Journal of Clinical and Aesthetic Dermatology, 8(12), 15–21.
  4. Massachusetts General Hospital. (2001, February 19). Blood Vessels Hold Key To Thicker Hair Growth. ScienceDaily. Retrieved March 2, 2017 from www.sciencedaily.com/releases/2001/02/010215074636.htm

How to Stop Hair Falling Out: The Best Method

The best method

If your hair has started falling out it’s most likely caused by a change in your hormones, which has increased levels of the hormone DHT in your body. DHT causes hair loss when it interacts with the hair follicles.

Warning
It’s important that you act fast. If you act quickly you have a much greater chance of stopping the hair loss and regrowing any lost hair. The longer you wait, the harder it gets to do something about it.

If you want to stop your hair loss fast and promote rapid hair growth, I recommend following this powerful hair growth method. That’s my top recommendation for getting the best results. Save that page and make sure you follow that method.

View the world’s most advanced at-home hair growth method.

Other, less effective ways top stop hair falling out

Use a topical containing minoxidil

Best topical hair loss treatments

There are numerous scientific ways of treating hair loss, reducing its effects and making your hair healthy. Topical treatments are possibly the most popular way to stop hair from falling out. Androgenetic alopecia will affect up to 70% of men and 40% of women at some point in their life, and according to most research, the best solutions are topical. Minoxidil has been successfully used to both prevent and stop hair loss and together with other treatments like finasteride can even help regrow hair. (Olsen et al., 2002)

See my list of the world’s best topical hair loss treatments to get the most effective topical.

Use a ketoconazole shampoo twice a week

Best ketoconazole shampoo

While minoxidil and finasteride are often quoted as the best combination of topical and pill based solutions for treating androgenetic alopecia, other topical substances have been proven to be similarly effective: for example a mix of minoxidil and ketoconazole, a synthetic imidazole antifungal drug that is often prescribed for fungal infections. The same antifungal ketoconazole mixed with finasteride was also shown to be even more effective in preventing and stopping baldness. (Khandpur et al. 2002)

Check out my list of the best ketoconazole shampoos to see what you can buy online.

Use a caffeine shampoo the rest of the week

Majestic Coffee hair loss shampoo

While it sounds rather far-fetched, caffeine can also help when it comes to stopping hair loss. Of course, consuming coffee the normal way won’t do much in the way of getting your hair back. However a shampoo or any other topical with very high doses of caffeine has been proven to reduce hair loss for both males and females and even promote hair growth. The science behind it shows that high doses of caffeine stimulated cell proliferation, inhibited apoptosis/necrosis, and upregulated IGF-1 gene expression and protein secretion. The shampoo can also be used on patients that have not lost their hair already as it has no effect on dead or dying hair roots. (Fischer et al. 2014)

References and further reading

  1. https://www.ncbi.nlm.nih.gov/pubmed/12196747
  2. Khandpur, S., Suman, M. and Reddy, B. S. (2002), Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men. The Journal of Dermatology, 29: 489–498. doi:10.1111/j.1346-8138.2002.tb00314.x
  3. Fischer, T. W., Hipler, U. C. and Elsner, P. (2007), Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. International Journal of Dermatology, 46: 27–35. doi:10.1111/j.1365-4632.2007.03119.x

How to stop hair thinning: the ultimate guide

Read this article carefully folks, because there are some real nuggets of wisdom in this article that could save your hair.

The three key factors to stopping your hair thinning are:

Replenishing key nutrients: If your hair isn’t fed, it will die

Spinach

Just like anything else, if your hair doesn’t receive the nutrients it needs, it will gradually die. In fact your hair will gradually grow smaller and smaller until it becomes too small to see (this is called hair follicle miniaturization).

What you didn’t know

The smoothie I describe in that email contains everything your body needs to make your hair grow

You may think your diet is OK. And it probably is. But what you might not have realized is many people are susceptible to impaired absorption of some nutrients. For example, women of a certain age are more likely to become deficient in the mineral iron. And iron is crucial for hair growth.

What’s more, if you suffer from high stress levels, you exercise a lot, don’t get enough sleep or work long hours your body might lack nutrients that are intensively used for recovery.

Fortunately there’s a very simple solution to these problems. I’ve developed a smoothie you can make at home, which contains the precise nutrients your body needs to make your hair grow. Submit your email address to the form on this page (if you’re browsing this page on a phone, tap on the “The key to hair growth” tab on the right hand side) and you’ll receive the smoothie instructions by email.

The smoothie I describe in that email contains everything your body needs to make your hair grow. If a nutrient deficiency like iron is the cause of your hair loss, that will stop it. It also contains superfoods that help reduce stress levels, balance hormones and protect your cells from free radicals. It’s the ultimate hair growth smoothie.

Good nutrition is one of the most important aspects of healthy hair. An iron deficiency could be the main cause of your hair thinning as iron deficiency is a known cause of hair loss. Increasing your zinc levels might also help prevent hair thinning due its critical role in the processes linked to the growth of the hair follicle. Selenium, fatty acids such as Omega 3 acids as well as Vitamin D also play a role in preventing and treating hair thinning. (Guo and Catta, 2017)

Reserveage Organic Green Drink Superfood Powder

The easiest way to make sure your body has everything it needs in just the right quantities is to drink my hair growth smoothie every day.

Extra tip: If you want to get a big dose of nutrients every day try buying a powdered green drink formula. Check out my review of the best organic green drinks to learn more.

How work stress and hormones are killing your hair

Cortisol is in essence, a stress hormone. … When we have high levels of cortisol coursing through the body this leads to an increase in adrenaline, testosterone and in particular, a hormone known as dihydrotestosterone or DHT
Dr Seymour Weaver

Most people are aware that male hormones have some impact on hair loss. It’s obvious when you walk outside and see that more men are bald than women. So male hormones (androgens) have some impact on hair loss.

But did you know that the stress hormone cortisol increases the hormone DHT, which is the biggest cause of hair loss.

DHT is the biggest cause of hair loss, but stress is the factor that increases the severity of the hair loss.

Testosterone is converted into DHT. You could have high testosterone and not experience hair loss. But high stress levels (high cortisol hormone levels) cause increased DHT, which is the hormone that causes hair loss.

There’s an incredible new way of solving this problem, by balancing your hormones, reducing stress levels and reducing scalp DHT levels. To see how it world check out the breakthrough hair regrowth method that’s transforming the hair loss industry.

How improper hair care might be causing your hair loss

Proper hair care is just as important as nutrition since the mechanical manipulation as well as environmental factors may affect your hair. By limiting the use of hair dryers, avoiding chemicals such as those contained by most hair dyes, stretching or perming your hair or even using the wrong type of shampoo for your type of hair, you will be able to prevent hair thinning (Gavazzoni Dias, 2015) and see an improvement in the way your hair looks and feels.

Three Free Hair Growth Tips: How to Stop Hair Thinning

Best ketoconazole shampoo

1. Use a ketoconazole shampoo: Ketoconazole is a chemical that kills a common fungi in the scalp that causes dandruff. It also reduces DHT in the scalp. So it’s an easy thing to do: wash your hair with a ketoconazole shampoo twice a week.

2. Brush your scalp. It sounds too simple to have any effect, but vigorously brushing your scalp with a hard bristled boar brush exfoliates your scalp removing dead skin cells. More importantly, it helps increase blood flow to your scalp, which brings nutrients to your hair.

3. Use one of the world’s best topical hair loss treatments twice a day. Read my guide on which ones to use and when. They might not make your hair grow back but they might slow it down.

What’s Best Advice for Stopping Hair Thinning?

My absolute best advice is to follow my method, the Hormone Fix, which fixes the underlying cause of hair loss.

Learn more about the Hormone Fix

References and further reading

  1. Guo, E. L., & Katta, R. (2017). Diet and hair loss: effects of nutrient deficiency and supplement use. Dermatology Practical & Conceptual, 7(1), 1–10. http://doi.org/10.5826/dpc.0701a01 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/
  2. Gavazzoni Dias, M. F. R. (2015). Hair Cosmetics: An Overview. International Journal of Trichology, 7(1), 2–15. http://doi.org/10.4103/0974-7753.153450 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387693/
    Wikramanayake, T. C., Villasante, A. C., Mauro, L. M., Perez, C. I., Schachner, L. A., & Jimenez, J. J. (2012).
  3. Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model. Cell Stress & Chaperones, 17(2), 267–274. http://doi.org/10.1007/s12192-011-0305-3
  4. Hu, R., Xu, F., Sheng, Y., Qi, S., Han, Y., Miao, Y., Rui, W. and Yang, Q. (2015), Combined treatment with oral finasteride and topical minoxidil in male androgenetic alopecia: a randomized and comparative study in Chinese patients. Dermatologic Therapy, 28: 303–308. doi:10.1111/dth.12246 https://www.ncbi.nlm.nih.gov/pubmed/26031764
    https://www.researchgate.net/profile/Osman_Koese/publication/8395671_An_Open_Randomized_Comparative_Study_of_Oral_Finasteride_and_5_Topical_Minoxidil_in_Male_Androgenetic_Alopecia/links/542a60580cf27e39fa8e8554.pdf